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Kidney Int：重组血管紧张素转换酶2可以减轻Alport综合征的肾损伤

2017-03-05 MedSci MedSci原创

ACE2Alport肾损伤
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血管紧张素转化酶2（ACE2）是肾素-血管紧张素系统中的单羧肽酶，它可以催化血管紧张素II向血管紧张素1-7的分解。已经有研究报道，在实验性Alport综合征中肾脏的ACE2表达减少，但是这一现象对疾病进展的影响尚未有研究报道。近期，一项发表在杂志Kidney Int上的研究评估了鼠重组ACE2治疗Col4a3基因敲除小鼠（蛋白尿和进行性肾损伤为特点的Alport综合征模型）的效果。通过渗透微型泵

血管紧张素转化酶2（ACE2）是肾素-血管紧张素系统中的单羧肽酶，它可以催化血管紧张素II向血管紧张素1-7的分解。


已经有研究报道，在实验性Alport综合征中肾脏的ACE2表达减少，但是这一现象对疾病进展的影响尚未有研究报道。

近期，一项发表在杂志Kidney Int上的研究评估了鼠重组ACE2治疗Col4a3基因敲除小鼠（蛋白尿和进行性肾损伤为特点的Alport综合征模型）的效果。

通过渗透微型泵从4周至7周龄的鼠予以鼠重组ACE2（0.5mg / kg /天）。

研究结果发现：予以鼠重组ACE2处理后，COL1α1mRNA的表达减少；细胞外基质蛋白的积累减少；转化生长因子-β信号传导抑制；说明肾损伤的病理变化得到缓解；并且改善了肾纤维化。此外，Col4a3敲除小鼠中促炎细胞因子表达，巨噬细胞浸润，炎症信号通路活化和血红素加氧酶-1水平的增加也通过鼠重组ACE2的处理降低。最后，鼠重组ACE2影响了肾ACE2的周转，抑制了肿瘤坏死因子-α转化酶（ACE2的负调节剂）的表达。因此，用外源性ACE2治疗改变了Col4a3敲除小鼠肾脏中的血管紧张素肽代谢，并减轻了Alport综合征肾病的进展。

原始出处：
Bae EH, Fang F, et al. Murine recombinant angiotensin-converting enzyme 2 attenuates kidney injury in experimental Alport syndrome. Kidney Int. 2017 Feb 26. pii: S0085-2538(17)30015-7. doi: 10.1016/j.kint.2016.12.022.

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    2017-03-21 仁医06

    #Alport#

    0

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    2017-06-25 jiekemin

    #ALP#

    0

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    2017-03-07 ms3046638856685384

    #损伤#

    0

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    2017-03-07 zhouqu_8

    #综合征#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1954066, encodeId=fff319540664c, content=<a href='/topic/show?id=c9a6235842' target=_blank style='color:#2F92EE;'>#Alport#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2358, encryptionId=c9a6235842, topicName=Alport)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Tue Mar 21 15:29:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035992, encodeId=1a1720359922f, content=<a href='/topic/show?id=01482345fc' target=_blank style='color:#2F92EE;'>#ALP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2345, encryptionId=01482345fc, topicName=ALP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c82369, createdName=jiekemin, createdTime=Sun Jun 25 16:29:00 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397137, encodeId=6ffa139e13764, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430761, encodeId=59611430e6193, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458425, encodeId=64dc145842555, content=<a href='/topic/show?id=782423592a' target=_blank style='color:#2F92EE;'>#Alport综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2359, encryptionId=782423592a, topicName=Alport综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6846069053, createdName=lancelotzzl, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589293, encodeId=d7571589293f2, content=<a href='/topic/show?id=fb0389e4373' target=_blank style='color:#2F92EE;'>#血管紧张素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89743, encryptionId=fb0389e4373, topicName=血管紧张素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ce517702394, createdName=xiongliangxl, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603007, encodeId=c679160300ef8, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=)]
    2017-03-07 lancelotzzl

    #Alport综合征#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1954066, encodeId=fff319540664c, content=<a href='/topic/show?id=c9a6235842' target=_blank style='color:#2F92EE;'>#Alport#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2358, encryptionId=c9a6235842, topicName=Alport)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Tue Mar 21 15:29:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035992, encodeId=1a1720359922f, content=<a href='/topic/show?id=01482345fc' target=_blank style='color:#2F92EE;'>#ALP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2345, encryptionId=01482345fc, topicName=ALP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c82369, createdName=jiekemin, createdTime=Sun Jun 25 16:29:00 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397137, encodeId=6ffa139e13764, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430761, encodeId=59611430e6193, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458425, encodeId=64dc145842555, content=<a href='/topic/show?id=782423592a' target=_blank style='color:#2F92EE;'>#Alport综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2359, encryptionId=782423592a, topicName=Alport综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6846069053, createdName=lancelotzzl, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589293, encodeId=d7571589293f2, content=<a href='/topic/show?id=fb0389e4373' target=_blank style='color:#2F92EE;'>#血管紧张素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89743, encryptionId=fb0389e4373, topicName=血管紧张素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ce517702394, createdName=xiongliangxl, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603007, encodeId=c679160300ef8, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=)]
    2017-03-07 xiongliangxl

    #血管紧张素#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1954066, encodeId=fff319540664c, content=<a href='/topic/show?id=c9a6235842' target=_blank style='color:#2F92EE;'>#Alport#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2358, encryptionId=c9a6235842, topicName=Alport)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Tue Mar 21 15:29:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035992, encodeId=1a1720359922f, content=<a href='/topic/show?id=01482345fc' target=_blank style='color:#2F92EE;'>#ALP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2345, encryptionId=01482345fc, topicName=ALP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c82369, createdName=jiekemin, createdTime=Sun Jun 25 16:29:00 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397137, encodeId=6ffa139e13764, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430761, encodeId=59611430e6193, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458425, encodeId=64dc145842555, content=<a href='/topic/show?id=782423592a' target=_blank style='color:#2F92EE;'>#Alport综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2359, encryptionId=782423592a, topicName=Alport综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6846069053, createdName=lancelotzzl, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589293, encodeId=d7571589293f2, content=<a href='/topic/show?id=fb0389e4373' target=_blank style='color:#2F92EE;'>#血管紧张素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89743, encryptionId=fb0389e4373, topicName=血管紧张素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ce517702394, createdName=xiongliangxl, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603007, encodeId=c679160300ef8, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Tue Mar 07 02:29:00 CST 2017, time=2017-03-07, status=1, ipAttribution=)]
    2017-03-07 gwc389

    #kidney#

    0