BMC Infect Dis:巨细胞病毒在HIV感染患者中的发病率、临床特征和预后

2020-11-08 MedSci原创 MedSci原创

随着抗逆转录病毒治疗的引入,巨细胞病毒感染急剧下降。然而,尚不清楚巨细胞病毒在HIV感染患者中的发病率、临床特征和预后是否随着时间的推移而发生变化。

随着抗逆转录病毒治疗的引入,巨细胞病毒感染急剧下降。然而,尚不清楚巨细胞病毒在HIV感染患者中的发病率、临床特征和预后是否随着时间的推移而发生变化。
采用回顾性单中心研究设计,纳入的患者均为2004-2015年期间就诊并被诊断为巨细胞病毒的HIV感染患者,在临床数据库中收集了流行病学、临床和实验室患者变量。评估了研究期间的临床特征、巨细胞病毒的发生率和死亡率的预测因素。
 
结果,研究期间,在HIV感染者中发现了56例巨细胞病毒感染病例(发病率为1.7例/1000人/年)。最常见的表现是全身性疾病,占43%。值得注意的是,没有患者出现眼科症状。30天的死亡率为18%。在单变量分析中,死亡率的预测因素是,入住重症监护室OR 32.4(3.65-287.06)p = 0.0001,机械通气84 OR(8.27-853.12)p = 0.0001,ART OR 4.1(0.97-17.31)p = 0.044。通过多变量分析评估这些变量,只有机械通气具有统计学意义(p<0.05)
综上所述,该研究结果表明,巨细胞病毒感染的发生率高于抗逆转录病毒治疗时代的描述。临床表现已发生了变化。机械通气可预测死亡率。
 
原始出处:
R Perello, A Vergara, et al., Cytomegalovirus infection in HIV-infected patients in the era of combination antiretroviral therapy. BMC Infect Dis. 2019 Dec 4;19(1):1030. doi: 10.1186/s12879-019-4643-6.

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    2021-05-01 zhaojie88
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    2020-11-09 wwzzly

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