率先开发促进肝脏再生的抗体治疗酒精性肝炎,Surrozen获得NIH资助

2020-10-16 MedSci原创 MedSci原创

酒精性肝炎(AH)是大量饮酒引起的炎症性肝损伤疾病,缺乏肝细胞的再生是AH患者的主要问题。

Surrozen获得NIH资助100万美元,支持其率先开发新型肝靶向再生抗体,用于刺激急性酒精性肝炎患者的肝细胞再生。

酒精性肝炎(AH)是大量饮酒引起的炎症性肝损伤疾病,发病率和死亡率均很高,而缺乏肝细胞的再生是AH患者的主要问题。肝细胞增殖水平的提高已被证明与患者良好的愈后相关。

靶向肝细胞的SZN-043目前正处于临床前开发治疗严重酒精性肝炎。在肝损伤的临床前模型中,用SZN-043治疗可以选择性刺激肝细胞再生并改善肝功能。“Surrozen首席科学官医学博士Ye Wen-Chen说:“SZN-043通过选择性激活肝脏中的Wnt信号通路,具有刺激肝功能受损患者肝脏再生的能力。”

A schematic representing cellular basis of Wnt/b-catenin activation... |  Download Scientific Diagram

图片来源:https://www.researchgate.net/figure/A-schematic-representing-cellular-basis-of-Wnt-b-catenin-activation-during-liver_fig3_262109595

Surrozen计划在2021年第四季度提交IND并开始临床试验。

关于Wnt信号通路

Wnt信号转导在多种重要器官和组织(包括肝脏,肠,肺,肾,中枢神经系统,耳蜗,骨骼等)的发育、体内稳态和再生控制中起着关键作用。调节Wnt信号通路具有治疗退行性疾病和组织损伤的潜力。

原始出处:

https://www.firstwordpharma.com/node/1765476?tsid=4

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    2020-10-18 宋威
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    2020-10-17 13c30453m58暂无昵称

    加油,要早早研究成功,病人获益

    0

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    2020-10-16 14750071m48(暂无昵称)

    前沿

    0

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当增加筛查持续降低结直肠癌总体发病率的同时,50岁以下结直肠癌患者的发病率却一直在增加,而且结直肠癌在年轻患者中也越来越成为一种常见的恶性疾病。近日,来自科罗拉多大学医学院的研究人员就揭示了在年轻患者中结直肠癌危险性增加的一种可能性原因,年轻患者和老年患者机体中往往存在很多相同的遗传改变,而年轻患者机体中更容易出现基因改变,比如Wnt信号通路发生改变,这种信号通路可以驱动癌症干细胞存活、生长及增殖

Journal of Molecular Cell Biology推出特辑

Journal of Molecular Cell Biology近日宣布出版2014年第一期特邀专辑,关注Wnt信号调节在防止大脑神经性退化和促进再生方面的研究进展。 几个世纪以来,Wnt信号缺失可诱发癌症已广为人知,但其信号通路在健康大脑功能中发挥何种作用仍是一个相对新兴的研究领域。细胞中Wnt信号异常调节已被认为是导致阿尔兹海默症和帕

Blood:巨噬细胞Epo受体信号促进应激造血时的红系分化

人类和小鼠的应激促红细胞生成都是利用与稳定状态下促红细胞生成不同的信号和祖细胞。

Sci Rep:WNT信号在人类胚胎癌细胞中的异常激活和对体外培养的短期和长期影响研究

人类胚胎癌细胞(EC)包括了恶性非精原细胞瘤性生殖细胞瘤(GCTs)的多能干细胞,并代表了胚胎干细胞(ESCs)的恶性成员。尽管WNT/β-连环蛋白信号在EC细胞中的作用研究较少,其在调控成熟和胚胎干细胞中具有作用。最近,有研究人员调查了WNT信号在代表性的多能和非多能人类EC细胞系中的作用。研究发现,EC细胞系表现出了不同水平的WNT信号,并对异常的WNT激活具有不同的响应。WNT信号的短期激活

Arthritis Rheumatol:滑膜Wnt信号诱导MMPs表达,并与早期症状性骨关节炎的疾病进展相关

通过增加MMPs的产生,滑膜中的Wnt信号可能有效诱导骨关节炎的进展。