Am J Gastroenterol:肝结节病临床表现与结果

2017-09-06 zhangfan MedSci原创

研究发现,仅6%的结节病患者出现结节病症状,大部分患者无症状。生化检查最常见的异常为碱性磷酸酶以及γ-谷氨酰转肽酶水平升高。多数患者肝活检显示出非干酪性肉芽肿

肝结节病的临床表现和结果缺乏相关的研究资料。近日研究人员开展了大规模人群基础队列研究,考察肝结节病患者特征。

研究人员考察了1976-2013年间,美国奥姆斯特德县肝结节病病例,对确诊的结节病病例进行回顾性分析,对患者的临床表现、影像学、肝生化检查、治疗和结果数据进行了分析,同时考察肝硬化累积发生率与死亡风险之间的关系。

研究期间共发生了345例结节病的病例,其中发生了19例肝受累(6%),肝受累患者平均年龄46.1岁,女性患者占53%,高加索裔占79%。大部分患者无症状性肝病,仅在生化检查和影像学中发现异常。88%以及90%的患者存在碱性磷酸酶(ALP)以及γ-谷氨酰转肽酶 (GGT)水平升高,但转氨酶升高不常见且不太严重。最常见的影像学异常为低密度结节性病变,约占50%,其次是肝肿大。88%的患者肝活检显示非干酪性肉芽肿,4名患者存在肝硬化。

研究发现,仅6%的结节病患者出现结节病症状,大部分患者无症状。生化检查最常见的异常为碱性磷酸酶以及γ-谷氨酰转肽酶水平升高。多数患者肝活检显示出非干酪性肉芽肿。

原始出处:

Patompong Ungprasert et al. Clinical Characteristics and Outcome of Hepatic Sarcoidosis: A Population-Based Study 1976-2013. Am J Gastroenterol. 5 September 2017.

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    2017-12-20 许安
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    2017-09-06 清风拂面

    谢谢分享.学习了

    0