Diabetes Obes Metab:2型糖尿病患者肥胖与严重COVID-19结局之间的关系

2020-10-16 MedSci原创 MedSci原创

在COVID-19住院的T2D患者中,超重和肥胖与早期预后不良相关。重要的是,在老年人中不再观察到肥胖对COVID-19预后的有害影响,这凸显了对该特定人群进行分类管理的必要性。

肥胖和糖尿病已被确定为常见的严重COVID-19相关的合并症。近日,代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇研究文章,研究人员旨在评估2型糖尿病(T2D)住院患者BMI分类与早期COVID-19预后之间的关系。

研究人员根据世界卫生组织分类分将T2D患者按照四个BMI亚组进行了分析。根据BMI状况分析了受试者临床特征和与COVID-19相关的结局(即机械通气插管[IMV]、第7天死亡和出院)。

在1965名T2D患者中,研究人员对434名(22.1%)正常体重(18.5-24.9 kg/m²,参考组),726名(36.9%)超重(25-29.9 kg/m²)和805名(41.0%)肥胖受试者进行了分析,其中I级肥胖(30-34.9 kg/m²)有491人(25.0%),II/III级肥胖(≥35kg/m2)有314人(16.0%)。在多变量调整模型中,主要结局(即IMV和/或第7天死亡)与超重(OR为1.65 [1.05-2.59])、I级(OR为1.93 [1.19-3.14])和II/III型肥胖(OR为1.98 [1.11-3.52])相关。经过多变量调整后,75岁以下的患者中第7天主要结局与肥胖显著相关,而在75岁以上的患者中不存在这种相关性。

由此可见,在COVID-19住院的T2D患者中,超重和肥胖与早期预后不良相关。重要的是,在老年人中不再观察到肥胖对COVID-19预后的有害影响,这凸显了对该特定人群进行分类管理的必要性。
 
原始出处:
 
Sarra Smati.et al.Relationship between obesity and severe COVID‐19 outcomes in patients with type 2 diabetes: results from the CORONADO study.Diabetes Obesity & Metabolism.2020.https://doi.org/10.1111/dom.14228

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    2020-10-30 一闲
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    2020-10-16 Jessica

    在老年人中不再观察到肥胖对COVID-19预后的有害影响,这是为什么呢?

    0

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    2020-10-16 misszhang

    谢谢MedSci提供最新的资讯

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