Eur Heart J:射血分数正常的心衰女性内脏脂肪组织的病理生理学意义

2020-11-26 MedSci原创 MedSci原创

过多的VAT积累在女性HFpEF患者的病理生理学机制中起着独特而重要的作用。需要进一步研究以更好地了解HFpEF患者内脏脂肪的作用和意义。

中央性肥胖是射血分数正常心衰(HFpEF)的主要危险因素,在女性中尤为明显,但机制尚未明确。近日,血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员假设内脏脂肪组织(VAT)含量的性别特异性差异与男性和女性HFpEF患者的血流动力学严重程度存在的差异相关。

研究人员对105名HFpEF患者(63名女性)和105名年龄、性别和体重指数匹配的对照者进行了腹部计算机断层扫描(CT)和有创血液动力学检查。通过CT对内脏脂肪组织面积进行定量。

与对照女性相比,HFpEF女性的VAT面积增加了34%(186±±112 cm2 vs. 139±±72 cm2,P=0.006),而伴有或不伴有HFpEF的男性VAT面积无显著差异(294±±158 vs. 252±92 cm2,P=0.1)。在运动过程中,男性和女性HFpEF患者的肺毛细血管楔压(PCWP)显著增加,并达到相似的程度。VAT面积增加的女性在运动期间的PCWP比正常面积的女性高33%(28%±10 vs. 21±10mmHg,P=0.001),而伴有或不伴有额外VAT的男性运动PCWP相似(24±9 vs. 25±6,P=0.89)。在女性中,VAT面积每增加100 cm2与PCWP升高4.0mmHg有关(95%CI为2.1-6.0mmHg;P<0.0001),但在男性中则没有这种关联(交互作用P=0.009)。

这些数据表明,过多的VAT积累在女性HFpEF患者的病理生理学机制中起着独特而重要的作用。需要进一步研究以更好地了解HFpEF患者内脏脂肪的作用和意义。

原始出处:

Hidemi Sorimachi,et al.Pathophysiologic importance of visceral adipose tissue in women with heart failure and preserved ejection fraction.European Heart Journal.2020.https://doi.org/10.1093/eurheartj/ehaa823

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  5. 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  6. 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    2020-11-28 rvn17

    希望更多的研究证实两者之间的关系

    0

  7. 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    2020-11-28 zhaojie88
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    2020-11-28 slcumt

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