Stroke:2017AHA/ASA脑动静脉畸形管理科学声明

2017-09-19 杨中华 脑血管病及重症文献导读

自从2001年AHA公布了脑动静脉畸形(bAVM)的声明后,bAVM的自然史和治疗结局等研究都取得了很大进展,特别是首个未破裂bAVM的随机对照试验ARUBA研究发表后bAVM的声明急需更新。

自从2001年AHA公布了脑动静脉畸形(bAVM)的声明后,bAVM的自然史和治疗结局等研究都取得了很大进展,特别是首个未破裂bAVM的随机对照试验ARUBA研究发表后bAVM的声明急需更新。

2017年8月Stroke杂志公布了最新AHA/ASA脑动静脉畸形管理的科学声明,现将其意见摘录如下:

一、未破裂bAVM管理建议:

1.应该让患者了解bAVM的自然史风险,它能够可靠地预测≈10年脑出血风险和≈5年癫痫风险
2.未破裂bAVM首次脑出血的风险≈1%/年。尚不清楚如何降低这种风险
3.未破裂bAVM首次痫性发作的5年风险≈8%,首次痫性发作后癫痫的5年风险≈58%
4.和患者讨论治疗方案时应该考虑到这些风险,认真衡量不同治疗策略的相对风险和预期寿命
5.可以采用SM量表(Spetzler-Martin grading scale)预测外科手术风险

二、破裂bAVM管理建议:

1.当临床或放射学资料有疑问时,非创伤性脑出血应该进行CTA、MRA和DSA检查评价是否存在bAVM(源自2015年ICH指南;IIa级,B级证据)
2.应该遵循2015年ICH指南管理脑出血
3.破裂bAVM脑出血复发的风险≈5%/年。年龄增长,深部静脉引流,动脉瘤和女性会增加这种风险
4.应该权衡各种治疗策略包括联合治疗策略的相对风险和获益

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    2017-11-28 lvygwyt2781
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    2018-09-02 fusion
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    2017-09-21 zhaohui6731
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    2017-09-21 wushaoling

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