Cell Rep:灵芝衍生物或有望帮助治疗非酒精性脂肪肝!

2020-08-17 佚名 细胞

研究报道了灵芝杂萜衍生物(GMD)的抗非酒精性脂肪性肝病的效应,研究者表示,GMD能增加拟杆菌属细菌的丰度从而激活拟杆菌属-叶酸-肝脏通路,进而减缓非酒精性脂肪肝患者的症状。

日前,一项刊登在国际杂志Cell Reports上的研究报告中,来自中国科学院微生物研究所等机构的科学家们通过研究报道了灵芝杂萜衍生物(GMD,Ganoderma meroterpene derivative)的抗非酒精性脂肪性肝病(NAFLD)的效应,研究者表示,GMD能增加拟杆菌属细菌的丰度从而激活拟杆菌属-叶酸-肝脏通路,进而减缓非酒精性脂肪肝患者的症状。

NAFLD是一种最常见的慢性肝病,如今其越来越成为影响全球人群健康的公共健康问题,然而目前并没有有效的药物批准用于治疗这种肝病,天然产物及其衍生物突出的化学多样性和生物活性就使其成为有望开发潜在药物的来源和焦点,比如灵芝(Ganoderma mushroom),其作为一种传统中药已经有几千年的药用历史了。

最近研究人员揭示了GMD在减缓大鼠非酒精性脂肪变性中的效应,研究者表示,摄入GMD能够增加机体的脂质氧化、抑制脂肪的从新合成以及脂肪从肝脏中的排出,同时还能抑制内毒素血症(endotoxemia)的发生,然而,作为一种活性制剂,其似乎不太可能通过口服被机体吸收,因此目前研究人员并不清楚GMD发挥效应的具体分子机制。

这项研究中,研究人员通过进行体外和体内实验,结果表明,工程化修饰后丁酸盐产量增加的肠道菌群及产叶酸肠道菌群或许能作为关键因子,从而促进GMD对NAFLD的治疗性效应,研究者识别出了由GMD所富集的四种能产叶酸的菌群,即解木聚糖拟杆菌(Bacteroides xylanisolvens)、多形拟杆菌(Bacteroides thetaiotaomicron)、单形拟杆菌(Bacteroides uniformis)和Bacteroides dorei,同时本文研究也首次报道了这四种肠道菌群能够产生叶酸。

通过口服解木聚糖拟杆菌(GMD促进作用最强的一种肠道菌群)就能减缓机体叶酸介导信号通路被激活的小鼠的肝性脂肪变性,为了证实肠道所产生的叶酸在NAFLD发生过程中扮演的关键角色,研究人员通过敲除叶酸生物合成途径中的folp基因旨在除了叶酸合成缺失的解木聚糖拟杆菌(BXΔfolP),结果发现,利用BXΔfolP来喂养小鼠或许就无法减缓其体内的NAFLD疾病表现。

最后研究者表示,本文研究揭示了灵芝衍生化合物GMD所介导的抗NAFLD效应,同时识别出了一种特殊有用的肠道拟杆菌-叶酸-肝脏轴或有望帮助开发治疗NAFLD的新型疗法,此外,研究人员还发现了一种潜在的益生菌或能帮助预防NAFLD的发生;总之,本文研究结果为后期科学家们深入开发治疗NAFLD的新型药物并扩展对该病发病机制的理解提供了新的思路和希望。

原始出处:

Shanshan Qiao, Li Bao, Kai Wang, et al. Activation of a Specific Gut Bacteroides-Folate-Liver Axis Benefits for the Alleviation of Nonalcoholic Hepatic Steatosis, Cell Reports (2020). DOI:10.1016/j.celrep.2020.108005

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likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:57:33 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2021-05-20 爆笑小医
  5. 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  6. 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  7. 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likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 15:57:33 CST 2020, time=2020-08-19, status=1, ipAttribution=)]
    2020-08-20 Slie

    新思路

    0

  8. 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    2020-08-19 ms5000000741733160

    👍🏻

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  9. 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    2020-08-19 ms5000000741733160

    👍

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  10. 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    2020-08-19 ms5000000741733160

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