Hypertension:唐氏综合症患儿血压下降

2020-01-14 xing.T MedSci原创

由此可见,该数据可潜在用于儿科唐氏综合症患者的评估和治疗。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,这项研究试图在多个中心分析唐氏综合症患儿的血压趋势。

研究人员进行了一项多中心、回顾性、横断面研究。所有患者均<18岁,并诊断为唐氏综合症。现有合并症是非排他性的。对于每位患者,通过常规的临床就诊获得了3次血压记录。

本研究共纳入了887位患者,总有2661次血压记录数据。患者的平均血压百分比为38.87%,中位数百分比为31.5%。年龄、性别和民族不能预测血压百分比。与美国国家心肺和血液研究所以及美国国家健康与营养检查调查队列(8-18岁)已知的数据相比,唐氏综合症人群的血压在统计学上降低了6.1个百分点(P<0.001),而较高的血压百分位数患者中差异最大(P<0.001)。所有唐氏综合症患者队列血压记录中,只有10%高于美国国家心肺和血液研究所/国家健康与营养检查调查的70%百分数,且没有患者符合高血压前期或高血压标准。与美国儿科学会的数据比较,结果相似,并且具有统计意义。与美国国家心肺和血液研究所/国家健康与营养检查调查以及美国儿科学会研究小组报告的年龄和身高匹配对照者相比,唐氏综合症患儿的基线血压降低了12个百分点。

由此可见,该数据可潜在用于儿科唐氏综合症患者的评估和治疗。

原始出处:

Jonathan D. Santoro.et al.Diminished Blood Pressure Profiles in Children With Down Syndrome.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.14416

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2039138, encodeId=2723203913869, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Dec 21 10:44:00 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728268, encodeId=e4ba1e2826886, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Dec 06 02:44:00 CST 2020, time=2020-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450343, encodeId=e5c7145034336, content=<a href='/topic/show?id=053a3999eea' target=_blank style='color:#2F92EE;'>#唐氏综合症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39997, encryptionId=053a3999eea, topicName=唐氏综合症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1eb25553762, createdName=huanbaofeng, createdTime=Thu Jan 16 14:44:00 CST 2020, time=2020-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501431, encodeId=17191501431cc, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jan 16 14:44:00 CST 2020, time=2020-01-16, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2039138, encodeId=2723203913869, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Dec 21 10:44:00 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728268, encodeId=e4ba1e2826886, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Dec 06 02:44:00 CST 2020, time=2020-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450343, encodeId=e5c7145034336, content=<a href='/topic/show?id=053a3999eea' target=_blank style='color:#2F92EE;'>#唐氏综合症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39997, encryptionId=053a3999eea, topicName=唐氏综合症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1eb25553762, createdName=huanbaofeng, createdTime=Thu Jan 16 14:44:00 CST 2020, time=2020-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501431, encodeId=17191501431cc, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jan 16 14:44:00 CST 2020, time=2020-01-16, status=1, ipAttribution=)]
    2020-12-06 一叶知秋
  3. [GetPortalCommentsPageByObjectIdResponse(id=2039138, encodeId=2723203913869, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Dec 21 10:44:00 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728268, encodeId=e4ba1e2826886, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Dec 06 02:44:00 CST 2020, time=2020-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450343, encodeId=e5c7145034336, content=<a href='/topic/show?id=053a3999eea' target=_blank style='color:#2F92EE;'>#唐氏综合症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39997, encryptionId=053a3999eea, topicName=唐氏综合症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1eb25553762, createdName=huanbaofeng, createdTime=Thu Jan 16 14:44:00 CST 2020, time=2020-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501431, encodeId=17191501431cc, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jan 16 14:44:00 CST 2020, time=2020-01-16, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2039138, encodeId=2723203913869, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Dec 21 10:44:00 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728268, encodeId=e4ba1e2826886, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Dec 06 02:44:00 CST 2020, time=2020-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450343, encodeId=e5c7145034336, content=<a href='/topic/show?id=053a3999eea' target=_blank style='color:#2F92EE;'>#唐氏综合症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39997, encryptionId=053a3999eea, topicName=唐氏综合症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1eb25553762, createdName=huanbaofeng, createdTime=Thu Jan 16 14:44:00 CST 2020, time=2020-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501431, encodeId=17191501431cc, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jan 16 14:44:00 CST 2020, time=2020-01-16, status=1, ipAttribution=)]

相关资讯

世界唐氏综合征日:这些产检千万别省

每年的3月21日被国际唐氏组织定为“世界唐氏综合征日”。1959年发现该病是由人体的第21对染色体的三体变异造成的现象。1965年将这一病症正式定名为“唐氏综合征”。它包含一系列的遗传病,会导致包括学习障碍、智能障碍和残疾等高度畸形。唐筛检查只能帮助判断胎儿患有唐氏征的机会有多大,但不能明确胎儿是否患上唐氏征。也就是说化验指数偏高时,怀有“唐”宝宝的机会较高,但并不代表胎儿一定有问题。除了唐筛

Jpn J Ophthalmol:唐氏综合征儿童的视觉特征

该研究分析早期接受眼科干预治疗的唐氏综合征儿童的长期视力发展情况。 研究选取了125名6岁前确证为唐氏综合征并且随访时间超过5年的儿童患者,对其视力发展、屈光度、视力检测和眼镜度数进行回顾性研究。

Nat Commun:揭秘唐氏综合症患者记忆与认知障碍关键机制,药物研发有望成功!

直到20世纪,人们才逐渐弄清唐氏综合征的真正病因:该病患者的染色体核型与正常人相比,多了一条21号染色体。随着对唐氏研究的深入,越来越多的成年唐氏患者皆表现出不同程度的空间定向缺陷。

J Pediatr:唐氏综合症儿童中听力损失的特性和发展分析

最近,有研究人员评估了唐氏综合症儿童中听力损失情况,并且还描述了在听力方面,随着时间的推移能够影响听力损失或者变化的因素。研究人员利用了听力学和基因数据库(AudGenDB),对患有唐氏综合症儿童的听力图在类型、严重度、听力损失偏重情况以及随着时间的变化情况进行了回顾性分析,还对医用图表和图像解雇进行了回顾来鉴定影响听力损失的因素。研究总共包括了1088名患有唐氏综合症的病人,其中921名至少有1

Stem cell rep:到底是什么杀死阿尔兹海默症患者的脑细胞?

近日发表在《Stem Cell Reports》上的一项新研究表明,我们可能需要重新思考阿尔兹海默症导致认知衰退的生物学机制。