Gastroenterology:1岁前抗生素暴露增加乳糜泻风险

2019-03-05 zhangfan MedSci原创

研究认为,出生后第一年,全身性抗生素暴露儿童的乳糜泻风险增加,儿童时期全身性抗生素暴露是乳糜泻的一个重要危险因素

肠道微生物失调,是除遗传和膳食结构之外,重要的乳糜泻发病机制。肠道微生物对抗生素十分敏感,尤其在早年。近日研究人员就新生儿出生后第一年全身应用抗生素与乳糜泻诊断之间的相关性进行了考察。

1995-2012年间丹麦和挪威新生儿参与研究,随访至2015年,共收集了170万多名儿童的信息,包括3346名乳糜泻患儿。

研究发现,出生后第一年全身应用抗生素与乳糜泻显著相关 (OR:1.26),并且抗生素使用与乳糜泻疾病风险之间存在剂量依赖关系(每增加一种抗生素的OR:1.08),该相关性不受抗生素种类和病因的影响。通过2个独立的大型儿童队列研究调整后,相关性略微降低 (OR:1.18)。

研究认为,出生后第一年,全身性抗生素暴露儿童的乳糜泻风险增加,儿童时期全身性抗生素暴露是乳糜泻的一个重要危险因素。

原始出处:

Stine Dydensborg Sander et al. Association Between Antibiotics in the First Year of Life and Celiac Disease. Gastroenterology. March 2, 2019.

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