J Rheumatol:感染与巨细胞动脉炎的患病风险升高相关

2020-05-21 xiangting MedSci原创

感染与随后出现经活检证实的GCA相关,尤其是呼吸道感染。

这项研究旨在探讨瑞典特定地区一个以人群为基础的大型队列中,感染与随后出现巨细胞动脉炎(GCA)的关联。

通过瑞典最南端斯科讷的病理学系数据库查找2000至2016年间经活检证实为GCA的患者。对于每个GCA病例,从普通人群中随机选择10个年龄、性别和居住地区相匹配的对照。研究人员使用斯科讷医疗保健登记,确定了GCA诊断日期和对照组指数日期之前的所有感染事件。将感染作为暴露,采用条件logistic回归模型估算发生GCA的比值比(OR)。确定了与GCA诊断/指数日期最接近的感染类型。

分析共纳入1005例经活检证实的GCA患者(女性占71%)和10050例对照。与对照相比,随后被诊断为GCA的患者中感染更常见[51%vs. 41%,OR 1.78;95%置信区间(CI)1.53-2.07]。急性上呼吸道感染(OR 1.77;95%CI 1.47-2.14)、流感和肺炎(OR 1.72;95%CI 1.35-2.19)和不明确的感染(OR 5.35;95%CI 3.46-8.28)与GCA相关。皮肤和胃肠道感染均未显示出与GCA有相关性。

感染与随后出现经活检证实的GCA相关,尤其是呼吸道感染。这项研究结果支持一系列感染可能触发GCA的假设。

原始出处:

Pavlos Stamatis. Infections are associated with increased risk of giant cell arteritis - a population-based case-control study from Southern Sweden. J Rheumatol.15 May 2020.

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    2020-10-09 xsm927
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    2020-05-23 wwzzly
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    2020-05-21 牛顿爱吃苹果哦

    学习了

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