Semin Arthritis Rheu:伴眼部受累巨细胞动脉炎患者的特征和结局

2020-03-22 xiangting MedSci原创

该研究观察到四分之一的GCA患者有眼部受累。AION仍与最差的视力预后相关,IV甲泼尼龙冲击治疗并不能降低失明的风险。

这项研究旨在描述诊断时患有巨细胞动脉炎(GCA)相关眼部受累患者的特征和预后。

这是一项纳入409例连续性GCA患者的回顾性单中心队列研究,其中104例在GCA诊断时存在视觉症状,研究人员将他们与104例年龄和性别匹配的无眼部受累的对照进行比较。每种视觉症状都与眼科诊断有关,而眼科诊断由眼科医生进行重新评估。

与对照组相比,伴有视觉症状的患者发烧(p=0.0006)和风湿性多肌痛较少见(p=0.02),急性期反应物水平较低(p=0.004)。在GCA诊断之前,患者描述了四种视觉症状:视力模糊(占患者的60%)、一过性黑矇(占18%)、复视(占13%)和永久性视力丧失(占9%)。47例患者(45%)出现前部缺血性视神经病变(AION),其次是15例患者(15%)出现了视网膜中央动脉阻塞(CRAO)。2例患者两种情况同时存在。有无视觉症状患者间的糖皮质激素的延迟治疗没有差异(p=0.06)。在60例有初始AION和/或CRAO患者中,尽管45例(75%)接受了甲泼尼龙静脉(IV)冲击治疗,仍有39例(65%)持续失明或严重视力受损。尽管已经开始治疗,仍有4%的视觉症状患者出现新的缺血事件(均为AION)。

该研究观察到四分之一的GCA患者有眼部受累。AION仍与最差的视力预后相关,IV甲泼尼龙冲击治疗并不能降低失明的风险。

原始出处:

Anaël Dumont. Characteristics and outcomes of patients with ophthalmologic involvement in giant-cell arteritis: A case-control study. Semin Arthritis Rheu. April 2020.

 

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    2021-02-02 xsm927
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    2020-06-21 huiwelcome
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    2020-03-24 zhaojie88
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    2020-03-24 wwzzly

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