IJIR:阴茎勃起功能异常能够影响慢性疼痛男性的人格和精神障碍

2020-05-28 AlexYang MedSci原创

慢性疼痛患者中的人格障碍(PDs)和性功能异常患病率要比普通人群高。最近,有研究人员分析了阴茎勃起功能障碍和具有慢性非癌疼痛患者中的PD影响,以及他们对雄激素治疗的响应情况。

慢性疼痛患者中的人格障碍(PDs)和性功能异常患病率要比普通人群高。最近,有研究人员分析了阴茎勃起功能障碍和具有慢性非癌疼痛患者中的PD影响,以及他们对雄激素治疗的响应情况。

研究包括了101名患者,为期30个月。研究人员分析了疼痛强度、生活质量、性生活质量、焦虑、抑郁及阿片类药物使用剂量,并使用了IIEF测量了勃起功能情况,还使用了MCMI-III评估了PDs情况。研究群体的平均年龄为57±12岁,且伴随中度到重度疼痛,其中70%的参与者为性活跃,且存在中度到重度的ED。研究发现,PDs的比例非常高(31%,截断值85;84%,截断值75),主要是焦虑、强迫、思想障碍、躯体形式障碍和自恋。自我挫败特性的存在于更加严重的基线ED和自恋(r=?0.4, 95%CI=?0.605到?0.145, p=0.002)以及对雄激素治疗更好的响应相关(p=0.010, d=1.082)。精神抑郁的患者与对照相比需要显著更高的阿片类药物剂量(分别为238和102?mg/day)。

最后,研究人员指出,他们的发现强调了PDs的诊断对有效治疗慢性疼痛和ED患者的重要性

原始出处:

Raquel Ajo, María-del-Mar Inda, Margarita Mateu et al. Personality and psychiatric disorders in chronic pain male affected by erectile dysfunction: prospective and observational study. IJIR. 07 May 2020

 

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    2020-12-10 habb
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    2020-05-30 dingxiaobo
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慢性疼痛不仅让人长期感觉疼痛,还会导致感觉迟钝甚至抑郁。现有一些镇痛药虽可缓解慢性疼痛,但可能会带来上瘾等严重副作用。美国一项新研究发现,一种名为RGS4的蛋白与慢性疼痛相关,未来有助于开发新的治疗疼痛药物。

Cell:芥末洋葱为何辣眼睛?背后机制有助于开发新型止疼药物

很多人有这样的体验,在切洋葱或者是吃芥末时会情不自禁地流眼泪。这是因为在洋葱、芥末和大葱等中含有一种特殊的物质——芥末受体。芥末受体会让人们产生眼睛刺痛的感觉,身体对这种疼痛感产生应激反应,通过流鼻涕、流眼泪等方式缓解疼痛。

Crit Care Med:危重病后慢性疼痛的发生和危险因素

由此可见,新发慢性疼痛是重症患者的常见结局,其对患者的日常生活影响巨大。

慢性疼痛与免疫系统密不可分

疼痛有三种主要类型:一是伤害性疼痛;二是神经性疼痛;三是功能性疼痛。

J Rheumatol:银屑病关节炎的疲劳是由炎症、病程和慢性疼痛引起的

PsA患者的疲劳是由临床炎症因素、病程和没有炎症的慢性疼痛引起的。