J Rheumatol:大动脉炎相关性肾动脉狭窄的特征和中期结局:中国大型队列研究

2020-05-09 xiangting MedSci原创

高血压和/或肾功能未受控制或恶化的TA相关性肾动脉狭窄患者会从血运重建中获益。接受过术前治疗的患者血运重建结局更好。

这项研究旨在探讨大动脉炎(TA)相关性肾动脉狭窄患者的特征,并确定中期不良结局的预测因素。

研究回顾性分析了2019年4月30日之前在华东大动脉炎队列研究登记的567例患者的数据。

172/567名患者(30.34%)证实有肾动脉狭窄,73/172名患者(42.44%)中可见左肾动脉受累。出现肾功能不全(HR=2.37,95%CI:1.76-15.83,p=0.03)、双侧肾动脉受累(HR=6.95,95%CI:1.18-21.55,p=0.01)和严重(>75%)狭窄(HR=4.75,95%CI 1.08-11.33,p=0.05)是不良结局的预测指标。使用3个指标(肾功能、狭窄严重度和双侧肾动脉受累)构建的矩阵模型可以确定三个风险组。46/172名患者(26.74%)进行了血运重建。术前未进行治疗的患者术后再狭窄(44.44%vs. 15.79%,p<0.01)和高血压恶化的几率较高(25.93%vs. 10.53%,p<0.01)。术前未接受治疗(HR=6.5,95%CI:1.77-32.98,p=0.04)和血运重建时疾病活动(HR=4.21,95%CI 2.01-21.44,p=0.04)是血运重建后不良结局的独立预测因素。

高血压和/或肾功能未受控制或恶化的TA相关性肾动脉狭窄患者会从血运重建中获益。接受过术前治疗的患者血运重建结局更好。表现为肾功能不全、双侧动脉受累和严重狭窄的患者预后似乎较差。

原始出处:

Ying Sun. Characteristics and medium-term outcomes of Takayasu arteritis–related renal artery stenosis: analysis of a large Chinese cohort. J Rheumatol. May 2020.

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    2024-01-11 tingtingff 来自山东省

    感谢分享

    0

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    2022-09-24 gqylhd

    肾萎缩患者比例?

    0

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    2022-03-10 maotouying

    不错,学习了

    0

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    2020-09-14 xsm927
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