Science:中年发福真的能甩锅给代谢变慢吗?

2021-08-14 haibei MedSci原创

最近,研究人员分析了一个大型的、多样化的数据库,通过双标记水法测量了年龄从8天至95岁的男性和女性的总支出。

所有基础的生命活动,从发育和繁殖到维护和运动,都需要能量。因此,每日总能量支出(总支出)是了解每日营养需求和身体在各项活动中的投入的核心。然而,目前,我们对人类的总支出或其在整个生命期的变化情况知之甚少。 大多数大型(n>1000人)的人类能量支出分析仅限于基础支出,即休息时的代谢率,而这只占总支出的一部分(通常是~50至70%),或者从基础支出和日常体力活动中估计总支出。双标水研究为测量自由生活的受试者的总支出提供了可能性,但又在样本量(n<600受试者)、地理和社会经济多样性和/或年龄方面受到限制。 身体成分、体型和体力活动在生命过程中的变化,往往是协同进行的,因此很难解析能量消耗的决定因素。已有的研究显示,随着儿童的成长和成熟,总支出和基础支出会随年龄的增长而增加,但对于增加体力活动和与年龄相关的组织特定代谢率变化的相对影响尚不清楚。同样,在老年人中开始的总支出的下降与无脂肪质量和体力活动的下降相对应,但也可能反映了与年龄相关的器官代谢的减少。 最近,研究人员分析了一个大型的、多样化的数据库,通过双标记水法测量了年龄从8天至95岁的男性和女性的总支出。总支出以幂律方式

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1008355, encodeId=4fa7100835579, content=已成为中年发福的一员 , beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=962c5467963, createdName=lancyteng, createdTime=Mon Aug 16 16:22:02 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376336, encodeId=181813e6336f1, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Mon Aug 16 06:52:28 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1008088, encodeId=7903100808883, content=活动也减少了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f582146110, createdName=1391ffebefm, createdTime=Sun Aug 15 15:40:06 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007980, encodeId=ccb3100e98060, content=代谢只是个具象的词语, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:57:24 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007978, encodeId=39fe100e9787e, content=协同进行,相互作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:53:57 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007977, encodeId=998d100e977bd, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:51:21 CST 2021, time=2021-08-15, status=1, ipAttribution=)]
    2021-08-16 lancyteng

    已成为中年发福的一员

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1008355, encodeId=4fa7100835579, content=已成为中年发福的一员 , beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=962c5467963, createdName=lancyteng, createdTime=Mon Aug 16 16:22:02 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376336, encodeId=181813e6336f1, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Mon Aug 16 06:52:28 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1008088, encodeId=7903100808883, content=活动也减少了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f582146110, createdName=1391ffebefm, createdTime=Sun Aug 15 15:40:06 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007980, encodeId=ccb3100e98060, content=代谢只是个具象的词语, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:57:24 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007978, encodeId=39fe100e9787e, content=协同进行,相互作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:53:57 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007977, encodeId=998d100e977bd, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:51:21 CST 2021, time=2021-08-15, status=1, ipAttribution=)]
    2021-08-16 jichang
  3. [GetPortalCommentsPageByObjectIdResponse(id=1008355, encodeId=4fa7100835579, content=已成为中年发福的一员 , beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=962c5467963, createdName=lancyteng, createdTime=Mon Aug 16 16:22:02 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376336, encodeId=181813e6336f1, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Mon Aug 16 06:52:28 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1008088, encodeId=7903100808883, content=活动也减少了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f582146110, createdName=1391ffebefm, createdTime=Sun Aug 15 15:40:06 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007980, encodeId=ccb3100e98060, content=代谢只是个具象的词语, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:57:24 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007978, encodeId=39fe100e9787e, content=协同进行,相互作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:53:57 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007977, encodeId=998d100e977bd, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:51:21 CST 2021, time=2021-08-15, status=1, ipAttribution=)]
    2021-08-15 1391ffebefm

    活动也减少了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1008355, encodeId=4fa7100835579, content=已成为中年发福的一员 , beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=962c5467963, createdName=lancyteng, createdTime=Mon Aug 16 16:22:02 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376336, encodeId=181813e6336f1, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Mon Aug 16 06:52:28 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1008088, encodeId=7903100808883, content=活动也减少了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f582146110, createdName=1391ffebefm, createdTime=Sun Aug 15 15:40:06 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007980, encodeId=ccb3100e98060, content=代谢只是个具象的词语, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:57:24 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007978, encodeId=39fe100e9787e, content=协同进行,相互作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:53:57 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007977, encodeId=998d100e977bd, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:51:21 CST 2021, time=2021-08-15, status=1, ipAttribution=)]
    2021-08-15 ms2000000776732748

    代谢只是个具象的词语

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1008355, encodeId=4fa7100835579, content=已成为中年发福的一员 , beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=962c5467963, createdName=lancyteng, createdTime=Mon Aug 16 16:22:02 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376336, encodeId=181813e6336f1, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Mon Aug 16 06:52:28 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1008088, encodeId=7903100808883, content=活动也减少了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f582146110, createdName=1391ffebefm, createdTime=Sun Aug 15 15:40:06 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007980, encodeId=ccb3100e98060, content=代谢只是个具象的词语, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:57:24 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007978, encodeId=39fe100e9787e, content=协同进行,相互作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:53:57 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007977, encodeId=998d100e977bd, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:51:21 CST 2021, time=2021-08-15, status=1, ipAttribution=)]
    2021-08-15 ms2000000776732748

    协同进行,相互作用

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1008355, encodeId=4fa7100835579, content=已成为中年发福的一员 , beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=962c5467963, createdName=lancyteng, createdTime=Mon Aug 16 16:22:02 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376336, encodeId=181813e6336f1, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Mon Aug 16 06:52:28 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1008088, encodeId=7903100808883, content=活动也减少了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f582146110, createdName=1391ffebefm, createdTime=Sun Aug 15 15:40:06 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007980, encodeId=ccb3100e98060, content=代谢只是个具象的词语, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:57:24 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007978, encodeId=39fe100e9787e, content=协同进行,相互作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:53:57 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007977, encodeId=998d100e977bd, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5805491837, createdName=ms2000000776732748, createdTime=Sun Aug 15 07:51:21 CST 2021, time=2021-08-15, status=1, ipAttribution=)]
    2021-08-15 ms2000000776732748

    好文章

    0

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增加心血管、痴呆等风险!预防衰老“秘诀”,可见于这两大策略

衰老细胞治疗(senotherapeutic)可以通过延长寿命和预期寿命来延缓衰老问题;而另一种预防衰老策略则是通过生活方式干预(包括健康饮食和身体活动)。

Skin Res Technol:关于肠道菌群和面部皮肤老化风险的遗传学见解:一项孟德尔随机化研究

研究结果证实了肠道菌群与面部皮肤衰老的因果关系,为延缓面部衰老提供了新的视角。