Prostate:根治性前列腺切除术患者的长期总生存率通常优于普通人群

2021-06-23 AlexYang MedSci原创

前列腺癌(PCa)有很好的治愈性治疗方案,大部分接受治疗的患者可望获得良好的肿瘤学结果。在不久的将来,PCa患者积极治疗后总生存的增加也是可期的。然而,由于PCa在老年人群中更为常见,而且与其他恶性肿

前列腺癌(PCa)有很好的治愈性治疗方案,大部分接受治疗的患者可望获得良好的肿瘤学结果。在不久的将来,PCa患者积极治疗后总生存的增加也是可期的。然而,由于PCa在老年人群中更为常见,而且与其他恶性肿瘤相比,其进展速度通常较慢,因此,在临床决策过程中,患者年龄和估计寿命(LE)是必须考虑的重要因素。

近期,有研究人员调查了德国前列腺癌(PCa)患者大队列中的总生存率,并将其与德国生命表得出的预期寿命(LE)预测值进行了比较。他们假设,前列腺根治术(RP)患者良好的总体健康状况与良好的癌症结果结合,可能会导致10年内的总生存率比一般人群的LE更高。

1992年至2007年期间,Martini-Klinik前列腺肿瘤中心共对6483名患者进行了RP治疗。术前风险分类是根据D'Amico进行的。术后风险分类是根据前列腺癌风险评估评分(CAPRA-S)进行的。使用Monte Carlo模拟创建了一个模拟队列,该队列与RP人群的确切年龄分布相似,该模拟基于德国官方男性生命表(1992-2017)中的数据。

结果发现,对于D'Amico低风险和中度风险,模拟队列的10年OS分别比预测的LE高12.0%和9.2%。对于D'Amico高风险,OS几乎与预测的LE相同(与RP治疗的患者相比有0.8%的差异)。对于CAPRA-S低度和中度风险,OS比预测的LE高11.8%和9.7%。对于CAPRA-S高风险,OS几乎与预测的LE相同(与模拟队列相比有0.3%的差异)。

根治性切除术前列腺癌患者的10年总生存与普通人群预期生存比较

综上所述,接受RP治疗的低风险和中风险PCa患者的总生存期非常好,甚至超过了LE预测值。高风险患者的总生存期与LE预测值基本完全一致

原始出处:

Christoph Würnschimmel, Mike Wenzel, Nuowei Wang et al. Long-term overall survival of radical prostatectomy patients is often superior to the general population: A comparison using life-table data. Prostate. Jun 2021

 

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    2021-06-25 guoyibin
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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Jun 25 13:04:37 CST 2021, time=2021-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614788, encodeId=7d1b1614e8828, content=<a href='/topic/show?id=b77f59959f2' target=_blank style='color:#2F92EE;'>#普通人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59959, encryptionId=b77f59959f2, topicName=普通人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b9519540847, createdName=ms9476844295372110, createdTime=Fri Jun 25 13:04:37 CST 2021, time=2021-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976465, encodeId=e9639e646555, content=那就是男人就把它切了吧。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ced1734358, createdName=1def5843m65(暂无匿称), createdTime=Thu Jun 24 10:04:51 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976458, encodeId=70fa9e64586b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67634708538, createdName=1356548325, createdTime=Thu Jun 24 09:35:08 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976449, encodeId=177b9e6449e5, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/6ed16e4a34fa46b6b10044c9d73004ae/88d1a640a56e4e76b4912368f9e828b6.jpg, createdBy=e5095532909, createdName=dazzleh18, createdTime=Thu Jun 24 08:59:58 CST 2021, time=2021-06-24, status=1, ipAttribution=)]
    2021-06-25 lsndxfj
  5. [GetPortalCommentsPageByObjectIdResponse(id=1877440, encodeId=cf4818e744060, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Wed Sep 29 17:04:37 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708885, encodeId=69e41e0888591, content=<a href='/topic/show?id=ffca32501e6' target=_blank style='color:#2F92EE;'>#前列腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32501, encryptionId=ffca32501e6, topicName=前列腺切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe731571573, createdName=1249898am25暂无昵称, createdTime=Thu Nov 18 06:04:37 CST 2021, time=2021-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256838, encodeId=9978125683863, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Fri Jun 25 13:04:37 CST 2021, time=2021-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364738, encodeId=49c71364e381d, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, 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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Jun 25 13:04:37 CST 2021, time=2021-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614788, encodeId=7d1b1614e8828, content=<a href='/topic/show?id=b77f59959f2' target=_blank style='color:#2F92EE;'>#普通人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59959, encryptionId=b77f59959f2, topicName=普通人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b9519540847, createdName=ms9476844295372110, createdTime=Fri Jun 25 13:04:37 CST 2021, time=2021-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976465, encodeId=e9639e646555, content=那就是男人就把它切了吧。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ced1734358, createdName=1def5843m65(暂无匿称), createdTime=Thu Jun 24 10:04:51 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976458, encodeId=70fa9e64586b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67634708538, createdName=1356548325, createdTime=Thu Jun 24 09:35:08 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976449, encodeId=177b9e6449e5, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/6ed16e4a34fa46b6b10044c9d73004ae/88d1a640a56e4e76b4912368f9e828b6.jpg, createdBy=e5095532909, createdName=dazzleh18, createdTime=Thu Jun 24 08:59:58 CST 2021, time=2021-06-24, status=1, ipAttribution=)]
    2021-06-25 jeanqiuqiu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1877440, encodeId=cf4818e744060, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Wed Sep 29 17:04:37 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708885, encodeId=69e41e0888591, content=<a href='/topic/show?id=ffca32501e6' target=_blank style='color:#2F92EE;'>#前列腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32501, encryptionId=ffca32501e6, topicName=前列腺切除)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encodeId=e9639e646555, content=那就是男人就把它切了吧。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ced1734358, createdName=1def5843m65(暂无匿称), createdTime=Thu Jun 24 10:04:51 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976458, encodeId=70fa9e64586b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67634708538, createdName=1356548325, createdTime=Thu Jun 24 09:35:08 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976449, encodeId=177b9e6449e5, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/6ed16e4a34fa46b6b10044c9d73004ae/88d1a640a56e4e76b4912368f9e828b6.jpg, createdBy=e5095532909, createdName=dazzleh18, createdTime=Thu Jun 24 08:59:58 CST 2021, time=2021-06-24, status=1, ipAttribution=)]
    2021-06-25 sunylz
  7. [GetPortalCommentsPageByObjectIdResponse(id=1877440, encodeId=cf4818e744060, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Wed Sep 29 17:04:37 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708885, encodeId=69e41e0888591, content=<a href='/topic/show?id=ffca32501e6' target=_blank style='color:#2F92EE;'>#前列腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32501, encryptionId=ffca32501e6, topicName=前列腺切除)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/6ed16e4a34fa46b6b10044c9d73004ae/88d1a640a56e4e76b4912368f9e828b6.jpg, createdBy=e5095532909, createdName=dazzleh18, createdTime=Thu Jun 24 08:59:58 CST 2021, time=2021-06-24, status=1, ipAttribution=)]
  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/6ed16e4a34fa46b6b10044c9d73004ae/88d1a640a56e4e76b4912368f9e828b6.jpg, createdBy=e5095532909, createdName=dazzleh18, createdTime=Thu Jun 24 08:59:58 CST 2021, time=2021-06-24, status=1, ipAttribution=)]
    2021-06-24 1def5843m65(暂无匿称)

    那就是男人就把它切了吧。

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/6ed16e4a34fa46b6b10044c9d73004ae/88d1a640a56e4e76b4912368f9e828b6.jpg, createdBy=e5095532909, createdName=dazzleh18, createdTime=Thu Jun 24 08:59:58 CST 2021, time=2021-06-24, status=1, ipAttribution=)]
    2021-06-24 1356548325

    学习

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/6ed16e4a34fa46b6b10044c9d73004ae/88d1a640a56e4e76b4912368f9e828b6.jpg, createdBy=e5095532909, createdName=dazzleh18, createdTime=Thu Jun 24 08:59:58 CST 2021, time=2021-06-24, status=1, ipAttribution=)]
    2021-06-24 dazzleh18

    值得学习

    0

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