J INTERN MED:糖尿病腹泻:胃肠运动、pH水平和自主功能的作用

2021-06-10 MedSci原创 MedSci原创

糖尿病腹泻患者胃肠道转运和管腔内pH水平改变,但自主神经功能变化很小。该研究的结果提示胃肠功能检测在糖尿病腹泻患者中具有重要的临床意义。

慢性腹泻是一种常见的糖尿病并发症,但研究较少。自主神经病变是一个主要的病理生理学理论,但是建立在古老的、小型的研究,对胃肠道运动和pH水平的研究较为缺乏。

近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章,研究人员采用新的诊断方法,旨在发现糖尿病腹泻是否与胃肠道运动、pH水平和自主神经功能改变相关。

57名(42名女性,46名1型糖尿病)患者被前瞻性纳入了研究。研究人员采用胃肠症状评定量表评定症状,评分≥4分定义为腹泻病例。患者评分<4分作为对照者。研究人员使用无线运动胶囊测量胃肠传输时间、pH水平和收缩参数。研究人员通过测量受试者心率变异性、压力反射敏感性和体位性低血压来评估自主神经功能。

17名患者(30%)有腹泻。与对照组相比,病例胃排空较慢(21:46 vs 4:14, h:min, p=0.03),结肠运输较快(18:37 vs 54:25, p<0.001)。腹泻患者胃窦(2.4 vs. 1.2, p=0.009)、盲肠(7.3 vs. 6.4, p=0.008)和全结肠(7.1 vs. 6.7, p=0.05)腔内pH值均升高。在幽门(3.3 vs. 4.9, p=0.004)和回盲肠连接处(0.6 vs. 1.0, p=0.009)的pH值差异也有所降低。两组患者自主神经功能无差异,但舒张压下降与结肠传输时间相关,rs=-0.34 (p=0.04)。

由此可见,糖尿病腹泻患者胃肠道转运和管腔内pH水平改变,但自主神经功能变化很小。该研究的结果提示胃肠功能检测在糖尿病腹泻患者中具有重要的临床意义

原始出处:

Dag A. Sangnes.et al.Diabetic diarrhoea: a study on gastrointestinal motility, pH levels and autonomic function.J INTERN MED.2021.https://doi.org/10.1111/joim.13340

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    2021-06-10 ms3000000257059085

    学习了

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    2021-06-10 misszhang

    谢谢MedSci提供最新的资讯

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