J INTERN MED:LDL-胆固醇水平是1型糖尿病儿童和成人视网膜病变和肾病的危险因素

2020-12-01 MedSci原创 MedSci原创

高LDL-胆固醇水平的1型糖尿病年轻人视网膜病变和肾病风险增加,而与血糖和其他已确定的血管并发症危险因素无关。

血管并发症在糖尿病患者中很常见,血糖控制不佳是其发生的主要因素。近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章,这项研究旨在探讨LDL-胆固醇水平升高与1型糖尿病年轻患者视网膜病变或肾病风险之间的关系。

这是一项全国性基于人群的观察性队列研究,其中包含了1998-2017年间在瑞典国家糖尿病登记中心注册的患有1型糖尿病持续时间≤10年的所有儿童和成人。研究人员计算了伴有95%置信区间(CI)的粗略发生率,并使用多变量Cox回归来估计四种LDL-胆固醇组的视网膜病或肾病的粗略和调整后风险比(HRs):<2.6(参考组)、2.6-3.4、3.4-4.1和>4.1 mmol/L。

诊断到研究结束,研究人员总共对儿童和成人(中位年龄为21岁,女性占42%)进行了11024/12350(分别是视网膜病变/肾病,两个队列)人次的随访。进入研究的糖尿病病程中位数在视网膜病和肾病队列中分别为6年和7年。LDL-胆固醇的中位数为2.4mmol/L,HbA1c的中位数为61 mmol/mol(7.7%)。

经过多变量调整后,LDL-胆固醇水平为2.6-3.4、3.4-4.1或>4.1 mmol/L的个体视网膜病变的HRs(95%CI)分别为:1.13(1.03-1.23)、1.16(1.02-1.32)和1.18(0.99-1.41),与参考组相比。肾病的相应HR分别为:1.15(0.96-1.32)、1.30(1.03-1.65)和1.41(1.06-1.89)。

由此可见,高LDL-胆固醇水平的1型糖尿病年轻人视网膜病变和肾病风险增加,而与血糖和其他已确定的血管并发症危险因素无关。

原始出处:

Björn Rathsman.et al.LDL‐cholesterol level as a risk factor for retinopathy and nephropathy in children and adults with type 1 diabetes mellitus: A nationwide cohort study.J INTERN MED.2020.https://doi.org/10.1111/joim.13212

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    2021-03-03 zy&kt

    已经出现糖尿病肾病的患者,控制好低密度脂蛋白胆固醇非常重要。

    0

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    2021-02-01 6322400001

    #糖尿病#有价值

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createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 09:18:45 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043415, encodeId=9fb01043415fe, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Dec 02 00:42:45 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
  4. 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channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904176, encodeId=9ea09041e692, content=高LDL-胆固醇水平的<a href='/topic/show?id=c6fc6e299' target=_blank style='color:#2F92EE;'>#1型糖尿病#</a>年轻人视网膜病变和肾病风险增加,因此对于1型糖尿病患者来说,监测LDL水平尤为重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=672, encryptionId=c6fc6e299, topicName=1型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 10:17:36 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904172, encodeId=19089041e27a, content=:LDL-胆固醇水平是1型糖尿病儿童和成人视网膜病变和肾病的危险因素,所以糖尿病人饮食时,一定要注意。要按照科学的糖尿病饮食来安排。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Dec 02 10:08:08 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904144, encodeId=3c669041444f, content=高LDL-胆固醇水平的1型糖尿病年轻人视网膜病变和肾病风险增加,而与血糖和其他已确定的血管并发症危险因素无关<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 09:18:45 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043415, encodeId=9fb01043415fe, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Dec 02 00:42:45 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
    2020-12-03 zhwj
  5. 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encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414011, encodeId=c06c141401156, content=<a href='/topic/show?id=27b290e82f4' target=_blank style='color:#2F92EE;'>#视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270264, encodeId=ee6612e026481, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, 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createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 09:18:45 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043415, encodeId=9fb01043415fe, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Dec 02 00:42:45 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
  6. 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encodeId=19089041e27a, content=:LDL-胆固醇水平是1型糖尿病儿童和成人视网膜病变和肾病的危险因素,所以糖尿病人饮食时,一定要注意。要按照科学的糖尿病饮食来安排。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Dec 02 10:08:08 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904144, encodeId=3c669041444f, content=高LDL-胆固醇水平的1型糖尿病年轻人视网膜病变和肾病风险增加,而与血糖和其他已确定的血管并发症危险因素无关<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 09:18:45 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043415, encodeId=9fb01043415fe, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Dec 02 00:42:45 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
    2020-12-03 zutt
  7. 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createdName=6322400001, createdTime=Mon Feb 01 15:40:40 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610811, encodeId=e1d71610811ca, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422596, encodeId=92ad1422596de, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414011, encodeId=c06c141401156, content=<a href='/topic/show?id=27b290e82f4' target=_blank style='color:#2F92EE;'>#视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270264, encodeId=ee6612e026481, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904176, encodeId=9ea09041e692, content=高LDL-胆固醇水平的<a href='/topic/show?id=c6fc6e299' target=_blank style='color:#2F92EE;'>#1型糖尿病#</a>年轻人视网膜病变和肾病风险增加,因此对于1型糖尿病患者来说,监测LDL水平尤为重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=672, encryptionId=c6fc6e299, topicName=1型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 10:17:36 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904172, encodeId=19089041e27a, content=:LDL-胆固醇水平是1型糖尿病儿童和成人视网膜病变和肾病的危险因素,所以糖尿病人饮食时,一定要注意。要按照科学的糖尿病饮食来安排。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Dec 02 10:08:08 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904144, encodeId=3c669041444f, content=高LDL-胆固醇水平的1型糖尿病年轻人视网膜病变和肾病风险增加,而与血糖和其他已确定的血管并发症危险因素无关<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 09:18:45 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043415, encodeId=9fb01043415fe, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Dec 02 00:42:45 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
    2020-12-02 heli0118

    高LDL-胆固醇水平的#1型糖尿病#年轻人视网膜病变和肾病风险增加,因此对于1型糖尿病患者来说,监测LDL水平尤为重要。

    0

  8. 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createdName=6322400001, createdTime=Mon Feb 01 15:40:40 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610811, encodeId=e1d71610811ca, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422596, encodeId=92ad1422596de, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414011, encodeId=c06c141401156, content=<a href='/topic/show?id=27b290e82f4' target=_blank style='color:#2F92EE;'>#视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270264, encodeId=ee6612e026481, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904176, encodeId=9ea09041e692, content=高LDL-胆固醇水平的<a href='/topic/show?id=c6fc6e299' target=_blank style='color:#2F92EE;'>#1型糖尿病#</a>年轻人视网膜病变和肾病风险增加,因此对于1型糖尿病患者来说,监测LDL水平尤为重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=672, encryptionId=c6fc6e299, topicName=1型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 10:17:36 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904172, encodeId=19089041e27a, content=:LDL-胆固醇水平是1型糖尿病儿童和成人视网膜病变和肾病的危险因素,所以糖尿病人饮食时,一定要注意。要按照科学的糖尿病饮食来安排。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Dec 02 10:08:08 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904144, encodeId=3c669041444f, content=高LDL-胆固醇水平的1型糖尿病年轻人视网膜病变和肾病风险增加,而与血糖和其他已确定的血管并发症危险因素无关<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 09:18:45 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043415, encodeId=9fb01043415fe, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Dec 02 00:42:45 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
    2020-12-02 Jessica

    :LDL-胆固醇水平是1型糖尿病儿童和成人视网膜病变和肾病的危险因素,所以糖尿病人饮食时,一定要注意。要按照科学的糖尿病饮食来安排。

    0

  9. 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channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904176, encodeId=9ea09041e692, content=高LDL-胆固醇水平的<a href='/topic/show?id=c6fc6e299' target=_blank style='color:#2F92EE;'>#1型糖尿病#</a>年轻人视网膜病变和肾病风险增加,因此对于1型糖尿病患者来说,监测LDL水平尤为重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=672, encryptionId=c6fc6e299, topicName=1型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 10:17:36 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904172, encodeId=19089041e27a, content=:LDL-胆固醇水平是1型糖尿病儿童和成人视网膜病变和肾病的危险因素,所以糖尿病人饮食时,一定要注意。要按照科学的糖尿病饮食来安排。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Dec 02 10:08:08 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904144, encodeId=3c669041444f, content=高LDL-胆固醇水平的1型糖尿病年轻人视网膜病变和肾病风险增加,而与血糖和其他已确定的血管并发症危险因素无关<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 09:18:45 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043415, encodeId=9fb01043415fe, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Dec 02 00:42:45 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
    2020-12-02 heli0118

    高LDL-胆固醇水平的1型糖尿病年轻人视网膜病变和肾病风险增加,而与血糖和其他已确定的血管并发症危险因素无关#糖尿病#

    0

  10. 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encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414011, encodeId=c06c141401156, content=<a href='/topic/show?id=27b290e82f4' target=_blank style='color:#2F92EE;'>#视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270264, encodeId=ee6612e026481, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Thu Dec 03 12:42:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904176, encodeId=9ea09041e692, content=高LDL-胆固醇水平的<a href='/topic/show?id=c6fc6e299' target=_blank style='color:#2F92EE;'>#1型糖尿病#</a>年轻人视网膜病变和肾病风险增加,因此对于1型糖尿病患者来说,监测LDL水平尤为重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=672, encryptionId=c6fc6e299, topicName=1型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 10:17:36 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904172, encodeId=19089041e27a, content=:LDL-胆固醇水平是1型糖尿病儿童和成人视网膜病变和肾病的危险因素,所以糖尿病人饮食时,一定要注意。要按照科学的糖尿病饮食来安排。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Dec 02 10:08:08 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904144, encodeId=3c669041444f, content=高LDL-胆固醇水平的1型糖尿病年轻人视网膜病变和肾病风险增加,而与血糖和其他已确定的血管并发症危险因素无关<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Dec 02 09:18:45 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043415, encodeId=9fb01043415fe, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Dec 02 00:42:45 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
    2020-12-02 misszhang

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