Brit J Cancer:中年体重增加是肥胖相关癌症的危险因素!

2018-06-13 xing.T MedSci原创

由此可见,中年体重增加是一个很强的癌症危险因素。在那些同时患有代谢异常的患者中具有更强的风险。

超重和糖尿病是癌症已知的危险因素。近日,肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章,该研究旨在调查中年时体重增加和代谢紊乱对肥胖相关癌症风险的独立和联合效应。

研究人员将Framingham子代研究中45至69岁的受试者(n=3850)根据当前和先前(14年前)的体重状况、中期体重变化和代谢功能障碍患病情况进行分类。研究人员对在基线超重和持续超重的受试者中,以及在随访期间超重的受试者中癌症风险与正常体重个体之间的风险进行比较。

在14年期间体重增加超过0.45kg(超过1磅)/年的受试者与维持稳定体重受试者相比,癌症风险增加了38%(95%可信区间(CI)为1.09-1.76);与代谢功能障碍相结合,体重增加使癌症风险增加77%(95%CI为1.21-2.59)。与非超重的成年人相比,中年时超重的男性和女性患癌症的风险分别增加了2.18倍和1.60倍;从基线超重的人分别增加28%和33%的患癌风险,尽管中年体重指数为3.4kg/m2高于后期体重增加者。

由此可见,中年体重增加是一个很强的癌症危险因素。在那些同时患有代谢异常的患者中具有更强的风险。

原始出处:


Susan Chadid,et al. Midlife weight gain is a risk factor for obesity-related cancer. British Journal of Cancer. 2018. https://www.nature.com/articles/s41416-018-0106-x

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    2018-06-20 phoebeyan520

    学习了.谢谢分享

    0

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    2018-06-14 张新亮1853311252142e2fm

    好文献学习了

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    2018-06-13 1e0f8808m18(暂无匿称)

    学习了.谢谢分享!

    0

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