Eur Heart J:他汀类药物可明显增加血浆脂蛋白a的水平

2020-06-29 MedSci原创 MedSci原创

脂蛋白(a)[LP(a)]在20%-30%的人群中都存在升高,本研究的目的旨在评估他汀类药物治疗对脂蛋白(a)水平的影响。

脂蛋白(a)[LP(a)]在20%-30%的人群中都存在升高,本研究的目的旨在评估他汀类药物治疗对脂蛋白(a)水平的影响。

本次荟萃分析纳入分析了来自6个随机对照临床试验中的5256名患者(1371名接受安慰剂,3885名接受他汀类治疗),脂蛋白(a)的水平检测用的是同一个试剂盒。在他汀类药物与安慰剂分析中,他汀类药物与安慰剂类药物的几何平均值[95%置信区间(CI)]的比值为1.11(1.07-1.14)(P<0.0001),比值>1表明他汀类药物与安慰剂组的Lp(a)较基线水平有更高的增加。与基线相比,他汀类药物组的平均百分比变化范围为8.5%至19.6%,安慰剂组为-0.4%至-2.3%。在他汀与他汀联合分析中,阿托伐他汀与普伐他汀的几何平均数(95%可信区间)之比为1.09(1.05-1.14)(P<0.0001)。普伐他汀组与基线相比的平均变化百分比为11.6%至20.4%,阿托伐他汀组为18.7%至24.2%。另外,用阿托伐他汀孵育HepG2肝细胞后,LPA mRNA和载脂蛋白(a)蛋白表达增加。

研究结果显示,他汀类药物可以明显增加血浆脂蛋白(a)的水平。

原始出处:

Sotirios T et al.Statin therapy increases lipoprotein(a) levels.Eur Heart J.2020 June.

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    2022-01-26 forvalen

    大多医院不查

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    2020-07-01 zhaojie88
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    2020-07-01 slcumt

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