Clin Chem:心脏和炎症生物标志物与2型糖尿病患者肾功能恶化有关?

2019-08-03 不详 MedSci原创

心脏和肾脏疾病通常会相互影响。据此,研究人员提出假设,心脏和炎症生物标志物可能有助于识别<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;; mso-fareast-font-family:宋体;mso

心脏和肾脏疾病通常会相互影响。据此,研究人员提出假设,心脏和炎症生物标志物可能有助于识别2糖尿病(T2DM)患者肾功能恶化的高风险。

在此,研究人员采用SAVOR-TIMI 53试探性分析方法,检测12310例患者血清中高敏感性心肌肌钙蛋白T (hs-TnT)n -末端前b型利钠肽(NT-proBNP)、高敏感性c -反应蛋白(hs-CRP)的浓度。这项分析的主要终点是在治疗结束时肾小球滤过率(eGFR)估计降低≥40%,平均为2.1年。生物标志物与终点之间的关系采用校正logisticCox回归建模。

研究显示,在对包括基线肾功能在内的多变量进行校正后,每个生物标志物均独立地与EOTeGFR降低≥40%的风险增加相关[四分位数(Q) Q4 vs Q1: hs-TnT校正优势比(OR) 5.63 (3.49-9.10);NT-proBNP校正OR, 3.53 (2.29-5.45);hs-CRP校正或,1.84 (95% CI, 1.27-2.68);所有P值≤0.001]。此外,每个生物标志物都与尿白蛋白肌酐比值(UACR)(所有P值均≤0.002)恶化的高风险独立相关。非心力衰竭患者和eGFR >60 mL/min的敏感性分析结果相似。在校正后的多标记模型中,hs-TnTNT-proBNP仍与两种肾脏结局显著相关(P值均<0.01)

研究表明,hs-TnTNT-proBNPhs-CRP均与高危T2DM患者肾功能恶化[eGFR降低≥40%UACR分级恶化]有关。高心脏或炎症生物标志物的患者不仅应治疗其心血管结局的风险,还应对肾功能恶化进行随访。

原始出处:

Thomas A. Zelniker, David A. Morrow, Cardiac and Inflammatory Biomarkers Are Associated with Worsening Renal Outcomes in Patients with Type 2 Diabetes Mellitus: Observations from SAVOR-TIMI 53

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    2019-12-10 yese
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    2019-08-03 misszhang

    谢谢MedSci提供最新的资讯

    0

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