Radiology:神经卷积网络自动测量肥厚性心肌病心肌瘢痕体积

2020-04-11 网络 网络

心脏MRI增强晚期(LGE)瘢痕体积是预测肥厚性心肌病(HCM)患者预后侧一项重要指标。但由于目前临床尚无标准的测量方法,其临床应用并未被广泛接受。

背景

心脏MRI增强晚期(LGE)瘢痕体积是预测肥厚性心肌病(HCM)患者预后侧一项重要指标。但由于目前临床尚无标准的测量方法,其临床应用并未被广泛接受。

目的

本研究旨在建立和评价一种基于3D卷积神经网络(CNN)的自动计算HCM患者LGE瘢痕体积的方法。

 

材料与方法

本研究回顾性分析了多个中心的LGE MRI数据。基于U网结构建立深度3D CNN用来评价LGE心肌瘢痕体积。按4:1进行分配训练组和测试组数据。短轴位MRI层面堆栈被分割为重叠的亚堆栈,然后合并为整个体积。利用Dice相似性系数(DSC)、Pearson相关系数和Bland-Altman分析来评估每个中心每个设备的心肌瘢痕定量结果。另外,比较3D CNN与2D CNN结果。

结果

本研究共纳入了1073例HCM患者。3D CNN定量方法计算速度快,与人工心肌瘢痕体积定量(r = 0.88, P < .001)、心肌瘢痕体积与左心室体积之比(%LGE) (r = 0.91, P < .001)结果具有很好的相关性。所有中心不同设备间基于3D CNN的定量方法与人工勾画心肌瘢痕体积结果具有很强的相关性。3D CNN能够识别较大的心肌瘢痕,其准确性约为98%(202/207) (95% CI: 95%, 99%)。与3D CNN相比,2D CNN会低估心肌瘢痕体积(r = 0.85, P < .001)和%LGE (r = 0.83, P < .001)。3D CNN的DSC在不同设备间相似(P = .07),且高于2D CNN(DSC, 0.54 ± 0.26 vs 0.48 ± 0.29; P = .02)。

结论

对于肥厚性心肌病患者来说,3D 卷积神经网络能够快速、准确地评估心肌瘢痕体积,其能力要优于2D 神经网络,该方法在不同设备间稳定性较好。

原始出处:

Fahmy AS, Neisius U, Chan RH.et al. Three-dimensional Deep Convolutional Neural Networks for Automated Myocardial Scar Quantification in Hypertrophic Cardiomyopathy: A Multicenter Multivendor Study.DOI:10.1148/radiol.2019190737

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    2020-04-11 子船

    很好的文章

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1810703, encodeId=08621810e03e6, content=<a href='/topic/show?id=cbd88605650' target=_blank style='color:#2F92EE;'>#自动测量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86056, encryptionId=cbd88605650, topicName=自动测量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f378286, createdName=shalley66, createdTime=Fri Oct 30 07:25:44 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336988, encodeId=8eb61336988ff, content=<a href='/topic/show?id=48f8e12220f' target=_blank style='color:#2F92EE;'>#瘢痕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71222, encryptionId=48f8e12220f, topicName=瘢痕)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fa82500120, createdName=12498a1cm67暂无昵称, createdTime=Mon Apr 13 00:25:44 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622442, encodeId=fa0816224427d, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Apr 13 00:25:44 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623111, encodeId=3f2d16231111d, content=<a href='/topic/show?id=fc1e5130694' target=_blank style='color:#2F92EE;'>#心肌瘢痕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51306, encryptionId=fc1e5130694, topicName=心肌瘢痕)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=425220488457, createdName=crystal0569, createdTime=Mon Apr 13 00:25:44 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381585, encodeId=3408381585c4, content=很好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK072iag9ZUdZlUTShgnYIesibGqico3Nw5HPeicLMoJTPeX2qHQFFnLZlAnlrENjoeZkg7RuOfxicurbw/0, createdBy=a3c72152837, createdName=子船, createdTime=Sat Apr 11 13:24:23 CST 2020, time=2020-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381580, encodeId=62353815802a, content=对其有了认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ea82329997, createdName=1226a71am04(暂无昵称), createdTime=Sat Apr 11 10:47:14 CST 2020, time=2020-04-11, status=1, ipAttribution=)]
    2020-04-11 1226a71am04(暂无昵称)

    对其有了认识

    0

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