Science:神经“连接”声音和疼痛!张智团队揭示低信噪比声音通过皮层-丘脑环路镇痛

2022-07-12 周科 神经周K

已有研究健康成年人在经历疼痛刺激时播放音乐可缓解疼痛,此外在疼痛患者中听音乐后也可在一定程度上减少疼痛。音乐缓解疼痛可能通过促进情绪功能发挥作用(引起听众强烈的情绪代入感,引起快乐),可能通过分散注意

已有研究健康成年人在经历疼痛刺激时播放音乐可缓解疼痛,此外在疼痛患者中听音乐后也可在一定程度上减少疼痛。音乐缓解疼痛可能通过促进情绪功能发挥作用(引起听众强烈的情绪代入感,引起快乐),可能通过分散注意力的认知功能实现的,可能通过促进内源性多巴胺或阿片肽类物质实现的。

但可能都不是通过上述这些机制实现的!

2022年7月8日中国科学技术大学生命科学学院张智、安徽医科大学基础医学院陶文娟和美国国立卫生研究院刘元渊团队揭示声音镇痛的神经环路机制。

图1:低信噪比声音信号可发挥镇痛作用

研究人员发现声音在75分贝以上(类似于繁忙闹市环境中的声音)能够明显引起小鼠逃跑行为,对于小鼠来说是伤害性的。他们发现在环境噪音45分贝背景下50分贝大小的声音可以明显提高疼痛模型小鼠的疼痛阈值,但60分贝的声音不具备这种镇痛效应。

有意思的是,无论是正常音调的声音还是音律紊乱的声音,抑或是白噪声,在环境噪音45分贝背景下这三种音律的分贝达到50分贝时,就能发挥镇痛效应。

他们将环境噪音提升到57分贝后只有在62分贝大小的声音可发挥镇痛效应,将环境噪音降低到30分贝后只有在35分贝大小的声音可增加疼痛模型小鼠的痛觉阈值,这就表明5分贝低信噪比(相对于背景噪音)可能具有缓解疼痛的作用。

图2:抑制听觉皮层神经元镇痛

声音信息由经典听觉传导通路传递至丘脑的内侧膝状体(MEG)进行整合 ,最终上行至听觉皮层进一步的分析和整合,从而实现感知。通过在体电生理技术发现疼痛模型小鼠在接受5分贝低信噪比声音刺激后听觉皮层神经元放电频率降低。此外,化学遗传学特异性抑制听觉皮层兴奋性神经元后发挥缓解疼痛的作用。

病毒示踪实验发现丘脑后核(PO)主要接受听觉皮层第6层谷氨酸能输入,腹后核(VP)接受来自于第5层输入。

在疼痛模型小鼠或机械刺激炎症模型小鼠后爪PO区域神经元活性增强,5分贝低信噪比声音刺激或抑制听觉皮层兴奋性神经元均能降低PO区域神经元活性。特异性抑制听觉皮层→丘脑后核环路后可发挥镇痛作用,在激活该神经环路后能够阻断5分贝低信噪比声音刺激引起的镇痛效应,

机械刺激炎症模型小鼠前爪VP区域神经元活性增强,5分贝低信噪比声音刺激可减弱这种增强。抑制听觉皮层→腹后核环路后可发挥镇痛作用,激活该神经环路后可阻断声音的镇痛效应。

总的来说,本文揭示了声音可通过抑制皮层-丘脑神经环路发挥镇痛作用,这种治疗作用并不是分散注意力引起的。

原始出处:

Sound induces analgesia throughcorticothalamic circuits. Science 377, 198–204 (2022).

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    2022-07-13 zhaojie88
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    2022-07-13 jichang
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