Clin Gastroenterology H:患有肠易激综合征的青少年女性发生子宫内膜异位症的风险比较高

2021-02-28 MedSci原创 MedSci原创

子宫内膜异位症是一种慢性炎性疾病,影响了全球约5%-10%的妇女,一项成人研究表明子宫内膜异位症与疼痛综合征(如纤维肌痛,慢性疲劳)之间存在关联。

      子宫内膜异位症是一种慢性炎性疾病,影响了全球约5%-10%的妇女,一项成人研究表明子宫内膜异位症与疼痛综合征(如纤维肌痛,慢性疲劳)之间存在关联。子宫内膜异位症患者也经常出现胃肠道症状。肠易激综合症(IBS)是一种功能性胃肠道疾病,其特征是腹痛与腹泻的频繁发生。子宫内膜异位症和IBS之间的潜在关系很复杂,在成人中两者的相关性已经得到一定的公认,但是年轻女性患者中这样的相关性还有待进一步研究。

 

 

      研究人员进行了一项针对有或没有子宫内膜异位症的绝经前女性的纵向研究,研究队列中纳入了2012年至2018年之间年龄小于21岁的参与者。参与者完成了广泛的健康调查问卷。那些以自我报告的诊断为基础或符合罗马IV诊断标准的IBS患者被认为是病例组,而没有IBS的患者则为对照组。同时通过问卷调查发现没有并发胃肠道疾病的有323人。最后使用逻辑回归的模型来统计IBS与子宫内膜异位症之间的相关性。

 

 

      与没有子宫内膜异位的青少年( 7.1%)相比,患有子宫内膜异位的青少年( 24%)合并IBS的概率明显增加。子宫内膜异位症患者的患IBS机率比其他患者高5.26倍(95%CI,2.13-13.0)。与无子宫内膜异位症的女孩相比,患有严重盆腔痛的女孩的发生IBS几率高35.7倍(95%CI,4.67–272.6)。对于子宫内膜异位症患者,盆腔疼痛严重程度每增加1个点,IBS的几率就会增加31%(OR:1.31; 95%CI为1.18-1.47)。

 

 

      本项研究发现:子宫内膜异位症与IBS之间存在显着关联,并且盆腔疼痛的严重程度与IBS的几率之间呈线性关系。

 

 

原始出处:

Amy D. DiVasta. Et al. Overlap Between Irritable Bowel Syndrome Diagnosis and Endometriosis in Adolescents. Clinical Gastroenterology and Hepatology.2021.

 

 

 

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    2021-05-26 许安
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    2021-03-03 ms6000001261338135

    IBS 与 子宫内膜异位

    0

  6. 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    2021-03-01 122ced3em37(暂无昵称)

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