JAHA:骨骼肌质量和脂肪质量与心血管疾病和全因死亡率的关联

2021-04-20 MedSci原创 MedSci原创

FM与CVD风险呈强正相关。aSMM与CVD风险的关系在不同性别中有所不同,潜在机制有待进一步研究。在预测人群水平的CVD发生率或全因死亡率方面,经生物阻抗测量的体脂和SMM并不优于体重指数。

体重指数是否可以很好地预测健康结局存在争议,因为不同的组织,即骨骼肌质量(SMM)和脂肪质量(FM),可能与风险存在差异。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员调查了四肢SMM(aSMM)和FM与致死性和非致死性心血管疾病(CVD)和全因死亡之间的关系。研究人员将他们的预后价值与体重指数进行了比较。

研究人员分析了356590名英国生物银行的参与者,年龄在40至69岁之间,他们通过生物阻抗分析数据获得全身FM,并预测的肢体肌肉质量(以计算aSMM)。研究人员使用多变量Cox比例风险模型评估了aSMM和FM与CVD和全因死亡率之间的关联。

研究人员进行了3749501人次每年的随访,共发生27784起CVD事件和15844起全因死亡。在男性中,aSMM与CVD的发生呈正相关(每增加1个SD的风险比[HR]为1.07;95%CI为1.06-1.09),女性之间存在曲线相关性。男性和女性FM与CVD之间存在更强的正相关性,每增加1个SD的HR分别为1.20(95%CI为1.19-1.22)和1.25(95%CI为1.23-1.27)。在FM三分位数中,aSMM与CVD风险之间的关联在很大程度上持续存在。aSMM和FM与男女全因死亡率之间存在J型关联。体重指数在辨别CVD风险方面稍有改善。

由此可见,FM与CVD风险呈强正相关。aSMM与CVD风险的关系在不同性别中有所不同,潜在机制有待进一步研究。在预测人群水平的CVD发生率或全因死亡率方面,经生物阻抗测量的体脂和SMM并不优于体重指数

原始出处:

Rebecca Knowles.et al.Associations of Skeletal Muscle Mass and Fat Mass With Incident Cardiovascular Disease and All‐Cause Mortality: A Prospective Cohort Study of UK Biobank Participants.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019337

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    2021-07-04 lshanp

    好思路,好想法,好研究

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GetPortalCommentsPageByObjectIdResponse(id=958621, encodeId=36779586212e, content=<a href='/topic/show?id=cf7f4e2366e' target=_blank style='color:#2F92EE;'>#少肌症#</a>未来将得到重视,它与<a href='/topic/show?id=3c34691e189' target=_blank style='color:#2F92EE;'>#生活质量#</a>极为相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47236, encryptionId=cf7f4e2366e, topicName=少肌症), TopicDto(id=69171, encryptionId=3c34691e189, topicName=生活质量)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Apr 20 07:29:02 CST 2021, time=2021-04-20, status=1, ipAttribution=)]
    2021-04-21 zhaohui6731
  4. 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  5. 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  6. 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    2021-04-21 易水河

    学习学习

    0

  7. 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    2021-04-20 ZJYYY7

    +22222

    0

  8. 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    2021-04-20 ZJYYY7

    taught

    0

  9. 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    2021-04-20 ZJYYY7

    Fm与cvd有关

    0

  10. 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    2021-04-20 病毒猎手

    #少肌症#未来将得到重视,它与#生活质量#极为相关

    0

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