BMJ:女性染发剂的使用与肿瘤风险评估

2020-09-05 MedSci原创 MedSci原创

永久性染发剂不会增加大多数肿瘤发病及死亡风险,但染发剂的累积剂量与基底细胞癌、部分乳腺癌和卵巢癌的风险增加相关。

近日研究人员评估了染发剂使用与肿瘤风险及死亡率的关系。

护士健康研究包含117200名女性参与者,基线检查时无肿瘤报告,在36年的随访期间,参与者报告了个人使用永久性染发剂的信息,评估参与者永久性染发剂的使用、持续时间、频率、累积使用剂量、首次使用时的年龄等信息。研究的主要终点为肿瘤及肿瘤死亡。

与从不使用染发剂的参与者相比,长期使用染发剂参与者的黑色素瘤皮肤癌以外实体癌(n=20805,危险比为0.98)或血液系统肿瘤(n=1807;1.00)的风险未见显著提高。此外,曾经使用过染发剂人群的大多数特定肿瘤(包括皮肤鳞状细胞癌、膀胱癌、黑色素瘤、雌激素受体阳性乳腺癌、孕酮受体阳性乳腺癌、激素受体阳性乳腺癌、脑癌、结直肠癌、肾癌、肺癌和大多数血液癌的主要亚类和组织学亚型)或癌症相关死亡的风险(n=4860;0.96)也未见显著提高。统计发现,曾经使用人群的基底细胞癌风险略有增加(n=22560;1.05)。值得关注的是,染发剂累积剂量与雌激素受体阴性乳腺癌、孕酮受体阴性乳腺癌、激素受体阴性乳腺癌和卵巢癌的风险增加相关。

染发剂导致的特定肿瘤风险与种族相关,自然黑色发色女性染发后霍奇金淋巴瘤风险增加(70名女性患者,其中24名为自然黑发人种),而自然浅色发色人群,染发后基底细胞癌风险更高。

研究认为,永久性染发剂不会增加大多数肿瘤发病及死亡风险,但染发剂的累积剂量与基底细胞癌、部分乳腺癌和卵巢癌的风险增加相关。

原始出处:

Yin Zhang et al. Personal use of permanent hair dyes and cancer risk and mortality in US women: prospective cohort study. BMJ. 02 September,2020.

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    2020-10-06 gaoxiaoe
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    2020-09-06 736631716

    还是要尽量少用!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2026051, encodeId=895e2026051fc, content=<a href='/topic/show?id=c3048314322' target=_blank style='color:#2F92EE;'>#肿瘤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83143, encryptionId=c3048314322, topicName=肿瘤风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Thu Jan 28 10:23:51 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849090, encodeId=d8ee184909081, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Oct 06 21:23:51 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=883203, encodeId=4816883203dd, content=还是要尽量少用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cbf4689089, createdName=736631716, createdTime=Sun Sep 06 23:45:31 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882917, encodeId=8e3488291e92, content=<a href='/topic/show?id=da1f10386e9f' target=_blank style='color:#2F92EE;'>#染发剂#</a>的累积剂量与基底细胞癌、部分乳腺癌和卵巢癌的风险增加相关。重没有染过发的路过,现在认为头发有光泽最好看,无论是黑色还是其他颜色。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103867, encryptionId=da1f10386e9f, topicName=染发剂)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Sat Sep 05 14:45:36 CST 2020, time=2020-09-05, status=1, ipAttribution=)]
    2020-09-05 Jessica

    #染发剂#的累积剂量与基底细胞癌、部分乳腺癌和卵巢癌的风险增加相关。重没有染过发的路过,现在认为头发有光泽最好看,无论是黑色还是其他颜色。

    0

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