J Gastroenterol:胃癌筛查计划对胃癌患者的长期预后的影响

2022-05-16 Nebula MedSci原创

采用上消化道内窥镜检查或在确诊前两年内进行胃癌筛查的患者的预后最好

胃癌是全球最常见的恶性肿瘤之一。根据GLOBOCAN 2020统计,2020年全球胃癌发病近110万例,在各类癌症相关死亡中居第三位。胃癌的发病率和死亡率存在明显的地域差异,其中约75%的病例发生在亚洲地区。

韩国国家癌症筛查计划 (KNCSP) 为 40 岁以上的成年人每两年提供一次上消化道检查 (UGIS) 或上消化道内窥镜检查。本研究旨在评估癌症筛查计划对胃癌患者长期预后的影响。

研究人员基于三个国家数据库构建了一个全国性的人群队列,纳入了2008-2009年期间确诊的46701位胃癌患者,随访至2019年末。主要终点是长期生存状态。


根据筛查史分层的确诊时不同分期胃癌患者的生存率

中位随访了10.5年,共有18614位(39.9%)患者死亡。筛查组患者的生存率高于非筛查组(65.8% vs 49.1%)。筛查组患者死于胃癌的风险降低了53%(HR 0.47)。


根据筛查方法分层的确诊时不同分期胃癌患者的生存率

与接受UGIS筛查的患者相比,接受上消化道内窥镜筛查的患者的胃癌特异性死亡率风险比更低(0.36 vs 0.69)。确诊癌症前两年内接受过筛查的患者的胃癌死亡风险降低35%,但自上次筛查后间隔时间超过3年的患者的该风险只降低了19%。

综上所述,该研究强调了胃癌筛查对胃癌患者生存预后的积极作用。采用上消化道内窥镜检查或在确诊前两年内进行胃癌筛查的患者的预后最好。

原始出处:

Luu Xuan Quy,Lee Kyeongmin,Jun Jae Kwan et al. Effect of gastric cancer screening on long-term survival of gastric cancer patients: results of Korean national cancer screening program.[J] .J Gastroenterol, 2022, https://doi.org/10.1007/s00535-022-01878-4

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    2022-09-02 许安
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