Circulation:他汀和PCSK9联合治疗的患者的残余炎症风险

2018-07-11 MedSci MedSci原创

他汀类药物联合PCSK9(9型前体蛋白转化酶枯草杆菌蛋白酶/kexin)抑制可显著降低低密度脂蛋白(LDL-C)和心血管事件率。目前尚不明确,在治疗后,以高灵敏度的C反应蛋白(hsCRP)所衡量的残余炎症风险是否仍是此类患者的重要临床问题。研究人员在参与SPIRE-1和SPIRE-2心血管预后试验的采用他汀和bococizumab联合治疗的9738位患者中,根据治疗14周时检测的hsCRP和LDL

他汀类药物联合PCSK9(9型前体蛋白转化酶枯草杆菌蛋白酶/kexin)抑制可显著降低低密度脂蛋白(LDL-C)和心血管事件率。目前尚不明确,在治疗后,以高灵敏度的C反应蛋白(hsCRP)所衡量的残余炎症风险是否仍是此类患者的重要临床问题。

研究人员在参与SPIRE-1和SPIRE-2心血管预后试验的采用他汀和bococizumab联合治疗的9738位患者中,根据治疗14周时检测的hsCRP和LDL-C水平来评估残余炎症风险。主要结点是非致死性心肌梗死和中风、因不稳定型心绞痛需紧急血管搭桥的住院或心源性死亡。

14周时,他汀类药物联合bococizumab治疗的患者的LDL-C和hsCRP的平均变化百分比分别是-60.5%(95% CI -61.2~-59.8;p<0.001;中位变化-65.4%)和6.6%(95% CI -1.0~14.1;p=0.09;中位变化 0.0%)。以治疗后hsCRP的水平分层(<1、1-3、>3mg/L)时,采用他汀和bococizumab联合治疗的患者未来心血管事件的发生率分别是1.96、2.50和3.59/100人年,根据传统心血管风险因素和LDL-C水平校正后多变量校正风险比分别是1.0、1.16(95% CI 0.81-1.66)和1.62(95% CI 1.14-2.30)(p=0.001)。治疗后LDL-C各水平(<30、30-50、>50mg/dL)的校正风险比分别是1.0、0.87和1.21(p=0.16)。

本研究提示在采用他汀和PCSK9联合治疗的稳定的门诊患者群中,仍持续存在残余炎症风险。

原始出处:

Aruna D. Pradhan, et al. Residual Inflammatory Risk on Treatment With PCSK9 Inhibition and Statin Therapy. Circulation. July 10,2018.https://doi.org/10.1161/CIRCULATIONAHA.118.034645

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    2019-05-17 Tamikia
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    2019-04-09 FukaiBao
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    2018-07-18 为你把脉

    好好好好聚聚

    0

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    2018-07-17 为你把脉

    唱唱歌股海护航

    0

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    2018-07-15 为你把脉

    VB会不会很几节课

    0

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    2018-07-14 为你把脉

    VB哈哈哈还好还好哈

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1685607, encodeId=9c9e168560e4f, content=<a href='/topic/show?id=a340138e48a' target=_blank style='color:#2F92EE;'>#PCS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13874, encryptionId=a340138e48a, topicName=PCS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=173d28230918, createdName=Tamikia, createdTime=Fri May 17 06:45:00 CST 2019, time=2019-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777264, encodeId=83201e7726404, content=<a href='/topic/show?id=678d5348a6' target=_blank style='color:#2F92EE;'>#Csk#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5348, encryptionId=678d5348a6, topicName=Csk)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=979839152460, createdName=FukaiBao, createdTime=Tue Apr 09 13:45:00 CST 2019, time=2019-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332526, encodeId=881f33252667, content=好好好好聚聚, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Wed Jul 18 19:28:03 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332230, encodeId=eb7033223069, content=唱唱歌股海护航, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Jul 17 11:16:31 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331751, encodeId=4dac331e518a, content=VB会不会很几节课, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Jul 15 09:52:17 CST 2018, time=2018-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331536, encodeId=050d33153670, content=VB哈哈哈还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sat Jul 14 13:01:30 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313707, encodeId=291e1313e0797, content=<a href='/topic/show?id=d4cc80e128f' target=_blank style='color:#2F92EE;'>#联合治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80712, encryptionId=d4cc80e128f, topicName=联合治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=263b421, createdName=zhaozuguo, createdTime=Fri Jul 13 01:45:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331129, encodeId=408433112911, content=VB吧拜拜宝贝宝贝, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Thu Jul 12 20:00:37 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=330821, encodeId=2752330821ef, content=cvgghhhhgg, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Wed Jul 11 10:48:39 CST 2018, time=2018-07-11, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1685607, encodeId=9c9e168560e4f, content=<a href='/topic/show?id=a340138e48a' target=_blank style='color:#2F92EE;'>#PCS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13874, encryptionId=a340138e48a, topicName=PCS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=173d28230918, createdName=Tamikia, createdTime=Fri May 17 06:45:00 CST 2019, time=2019-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777264, encodeId=83201e7726404, content=<a href='/topic/show?id=678d5348a6' target=_blank style='color:#2F92EE;'>#Csk#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5348, encryptionId=678d5348a6, topicName=Csk)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=979839152460, createdName=FukaiBao, createdTime=Tue Apr 09 13:45:00 CST 2019, time=2019-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332526, encodeId=881f33252667, content=好好好好聚聚, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Wed Jul 18 19:28:03 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332230, encodeId=eb7033223069, content=唱唱歌股海护航, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Tue Jul 17 11:16:31 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331751, encodeId=4dac331e518a, content=VB会不会很几节课, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Jul 15 09:52:17 CST 2018, time=2018-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331536, encodeId=050d33153670, content=VB哈哈哈还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sat Jul 14 13:01:30 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313707, encodeId=291e1313e0797, content=<a href='/topic/show?id=d4cc80e128f' target=_blank style='color:#2F92EE;'>#联合治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80712, encryptionId=d4cc80e128f, topicName=联合治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=263b421, createdName=zhaozuguo, createdTime=Fri Jul 13 01:45:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331129, encodeId=408433112911, content=VB吧拜拜宝贝宝贝, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Thu Jul 12 20:00:37 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=330821, encodeId=2752330821ef, content=cvgghhhhgg, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Wed Jul 11 10:48:39 CST 2018, time=2018-07-11, status=1, ipAttribution=)]
    2018-07-12 为你把脉

    VB吧拜拜宝贝宝贝

    0

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    2018-07-11 为你把脉

    cvgghhhhgg

    0

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