Sci Rep:类风湿性关节炎的血清铁调素水平、铁代谢和骨质疏松

2020-06-21 xiangting MedSci原创

这项研究表明,血清铁调素和血清铁与RA患者的骨质疏松有间接和直接关联。

铁调素是铁代谢和体内稳态的主要调节剂,受炎症的调节。最近的研究表明,铁调素和铁代谢与骨质疏松症有关,这项研究目的是确定类风湿性关节炎(RA)患者的血清铁调素水平是否与骨质疏松的程度相关。

共有262名RA患者入选(67.5±11.4岁;女性占77.5%)。血清铁、铁蛋白和铁调素水平彼此呈正相关。多因素回归分析表明,血清铁水平与股骨T和Z评分呈正相关,而血清铁调素水平与股骨T和Z评分无关。血清铁调素水平与血清​​25-羟维生素D水平相关,而血清25-羟维生素D水平反过来又与股骨Z评分呈正相关。

这项研究表明,血清铁调素和血清铁与RA患者的骨质疏松有间接和直接关联。

原始出处:

Hiroe Sato. Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis. Sci Rep. 18 June 2020.

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    2020-12-30 mnda
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    2020-06-23 lmm397
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    2020-06-23 syscxl
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    2020-06-23 Eleven17

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对于骨质疏松性椎体重度压缩骨折,无论是采用内固定技术还是骨水泥成形术均存在较大难度,影响手术疗效。椎体支架成形技术(VBS)相比经皮椎体成形术(PVP),能够有效地恢复椎体高度,并在术后较大程度地减少高度丢失。我们收治了1例骨质疏松性腰椎压缩骨折伴重度压缩患者,择期行VBS手术,术后随访疗效满意,报告如下。

J Clin Endocrinol Metab:增加膳食钙摄入量预防骨质疏松,可能并不靠谱

众所周知,现实生活中人们的钙摄入量通常低于推荐水平,故临床医生常推荐增加钙摄入量以促进骨骼健康。绝经后女性无疑是一个需要增加钙摄入量来促进骨骼健康的重点人群。那么,对于绝经后女性而言,膳食钙摄入量到底会对骨量流失速率有着怎样的影响?通过增加膳食钙摄入量来预防骨质疏松是否可行?近期发表的一项最新研究专门探讨了老年女性膳食钙摄入量与骨量流失速率之间的关系,其研究结果发表在近期的J Clin Endoc

Cell Death Dis:eIF2α信号参与调节成骨细胞和破骨细胞的平衡

绝经后骨质疏松症的骨流失主要是由于骨形成相关成骨细胞和骨吸收相关破骨细胞的失衡所引起的。 Salubrinal是一种合成的化合物,可选择性抑制eIF2α(真核翻译起始因子2α)的去磷酸化。 eIF2α磷酸化可减轻内质网(ER)应激作用,进而可能会激活细胞的自噬作用。在本研究中,研究人员推测eIF2α信号可以通过促进成骨细胞的自噬和抑制破骨细胞的发育来调节骨内稳态。为了验证这一推测,研究人员使用sa

乳腺癌综合治疗中骨质疏松预防刻不容缓

乳腺癌是中国女性最为常见的恶性肿瘤,年新发病例超过达27万。随着乳腺癌诊疗水平的提高,乳腺癌患者长期生存的几率越来越大。因此,对于很多乳腺癌患者而言,关注的不仅仅只有肿瘤治疗,如何防治乳腺癌综合治疗中出现的骨质疏松、心血管疾病是目前乳腺癌综合治疗中亟待解决的问题。

2020 EMAS/IGCS立场声明:妇科癌症后绝经期管理—聚焦围绝经期综合征和骨质疏松

2020年2月,欧洲女性与男性更年期协会(EMAS)与国际妇科肿瘤学会(IGCS)发布了妇科癌症后绝经期管理声明,主要内容聚焦聚焦围绝经期综合征和骨质疏松的管理。全世界范围内,每年约有130万新诊断的妇科肿瘤患者,这些患者接受的治疗方式包括子宫切除伴或不伴双侧输卵管卵巢切除术、放疗和化疗,可导致卵巢功能丧失,进而使绝经期提前。本文的主要目的是针对妇科肿瘤患者围绝经期综合征以及骨质疏松提供个体化的管