ATVB:软骨寡聚基质蛋白新表位是症状性颈动脉狭窄的新型生物标志物

2021-01-23 网络 网络

COMP的降解可能与动脉粥样硬化的进展和特定的COMP片段(COMPneo)产生有关。COMPneo可能是了一种新的生物标志物,与COMPtotal和其他风险标志物一起用于识别症状性颈动脉狭窄。

软骨寡聚基质蛋白(COMP)在血管系统、软骨和动脉粥样硬化斑块中大量表达。近日,心血管领域权威杂志Arteriosclerosis, Thrombosis, and Vascular Biology上发表了一篇研究文章,研究人员旨在调查总的COMP(COMPtotal)和COMP新表位(COMPneo)以及其他心血管标志物和临床参数是否可以识别症状性颈动脉狭窄。

研究人员收集了症状性颈动脉狭窄患者(狭窄组,n=50)、无颈动脉狭窄但有小斑块(斑块组,n=50)卒中患者和对照者(n=50)的血液样本,并使用ELISA测量COMPtotal和COMPneo。研究人员通过Olink CVD试剂盒测量了92种心血管疾病标志物。通过免疫组织化学确定COMP和COMPneo的表达情况。

狭窄组中COMPneo的浓度较高,而COMPtal的浓度较低。当比较狭窄组和对照组IL-1ra、IL6(白介素-6)、REN(肾素)、MMP-1(基质金属蛋白酶-1)、TRAIL-R2(肿瘤坏死因子相关凋亡诱导配体受体2)、ITGB2(整合素亚基beta1结合蛋白2)和COMPneo的浓度可以预测狭窄。相反,KLK6(激肽释放酶-6)、COMPtotal、NEMO、SRC(原癌基因酪氨酸蛋白激酶Src)、SIRT2(SIR2样蛋白)、分化簇40、TF(组织因子)、MG和晚期受体糖基化终产物可预测对照者。模型的重复性良好,受试者工作特性曲线下面积为0.86。当将斑块组和狭窄组比较时,COMPneo、GAL和PTX-3可以预测狭窄。模型的重复性极好(受试者工作特性曲线下面积为0.92)。在颈动脉狭窄的平滑肌、内皮细胞和泡沫细胞中均检测到了COMPneo表达。

由此可见,COMP的降解可能与动脉粥样硬化的进展和特定的COMP片段(COMPneo)产生有关。COMPneo可能是了一种新的生物标志物,与COMPtotal和其他风险标志物一起用于识别症状性颈动脉狭窄

原始出处:

Joakim Sandstedt.et al.COMP (Cartilage Oligomeric Matrix Protein) Neoepitope A Novel Biomarker to Identify Symptomatic Carotid Stenosis.ATVB.2021.https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.314720

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    2021-10-12 gongliu
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  5. 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  6. 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  7. 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