Stroke:心率对房颤合并急性缺血性卒中患者复发和死亡率的影响

2019-12-04 xing.T MedSci原创

由此可见,在急性缺血性卒中住院的房颤患者中,急性卒中期间的平均心率与卒中复发无关,但与死亡率有关(非线性,J形关联)。关于心率变异性,未观察到心率与患者结局之间的关联。

关于静息心率在房颤合并缺血性卒中患者结局事件预测中的作用信息很少。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在探究房颤患者急性卒中期间心率水平和变异性与急性缺血性卒中患者卒中复发和死亡率之间的关系。

研究人员从多中心前瞻性卒中登记数据库中确定了伴有房颤且卒中发病48小时内住院的急性缺血性卒中患者。急性卒中分为早期(住院24小时内)和晚期(发病后72小时至7天),并收集了两个阶段的心率数据。此外,使用平均值和变异系数评估心率的水平和变异性。前瞻性监测卒中后1年的结局事件。

符合早期急性期分析标准的2046例患者中,卒中后一年内有102例(5.0%)发生卒中复发,440例(21.5%)死亡。在平均心率和死亡率之间观察到统计学上显著的非线性J形关联(对于二次和总体影响,P<0.04),但是在平均心率和卒中复发之间则没有(对于二次和总体影响,P>0.1)。对于所有结局变量,心率变异系数的非线性和整体影响均不显著。在晚期急性期分析中(n=1576)也观察到了相同的结果。

由此可见,在急性缺血性卒中住院的房颤患者中,急性卒中期间的平均心率与卒中复发无关,但与死亡率有关(非线性,J形关联)。关于心率变异性,未观察到心率与患者结局之间的关联。 

原始出处:

Keon-Joo Lee.et al.Effect of Heart Rate on Stroke Recurrence and Mortality in Acute Ischemic Stroke With Atrial Fibrillation.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.026847

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    2019-12-05 qingfengqishi5

    学习了,学习了

    0

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    2019-12-04 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2019-12-04 心介

    房颤,临床上碰到很多哦

    0

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JAMA:很大样本房颤消融和药物治疗随机对照研究:主要终点无差异,但住院率降低,生活质量提高

CABANA研究在2018年美国心律学会科学年会发布以来,余波未息。近日,该研究正式在JAMA发表。

小儿支气管异物取出术中异物形成单向活瓣致心率下降1例

患儿,女性,13个月,体重10kg,诊断为左侧支气管异物,病程3d,异物为熟鸡蛋,拟急诊静吸复合麻醉联合气管内表面麻醉下行支气管镜气管异物取出术。