Nat Neurosci.：多发性硬化治疗新方向：小胶质细胞可以清除多发性硬化症中的有毒脂质

2021-04-27 VONVEY MedSci原创

氧化磷脂酰胆碱(OxPCs)在驱动中枢神经细胞死亡中有直接作用。由脂质传感器TREM2和中和性OxPC抗体介导的小胶质细胞活性能够挽救OxPC诱导的神经毒性。

Dong及其同事研究了多发性硬化中介导神经退行性变的机制，并确定了氧化磷脂酰胆碱(OxPCs)在驱动中枢神经细胞死亡中的直接作用。由脂质传感器TREM2和中和性OxPC抗体介导的小胶质细胞活性能够挽救OxPC诱导的神经毒性。多发性硬化症(MS)是一种自身免疫性疾病，其特征是脱髓鞘和神经退行性过程，包括轴突损伤，在最严重的情况下，中枢神经系统的神经元丢失。这种使人衰弱的疾病是年轻人神经功能障碍的主要原因，大多数病例在20-50岁之间确诊。尚未发现多发性硬化症的致病基因;然而，全基因组关联研究已经确定了超过200个变异和涉及适应性和先天免疫系统的细胞。MS的病理特征是大脑或脊髓的脱髓鞘病变，被自我反应性适应性免疫细胞侵犯。关于多发性硬化疾病进展的广泛观点是，自身免疫淋巴细胞攻击并破坏髓鞘，使少突胶质细胞和轴突容易死亡，从而导致随后的神经变性，但髓鞘碎片是否导致神经毒性，如果是，涉及什么机制尚不清楚。Dong等人在Nature Neuroscience杂志上指出，氧化磷脂酰胆碱(OxPCs)只存在于多发性硬化病变中，而不在相邻的正常白质中。在此之前，OxPCs在MS病变中有报道，但Dong

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2021-10-22 liye789132251

#Nat#

42 0
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2021-05-30 30397604

#硬化症#

55 0
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2022-01-20 jml2009

#多发性#

57 0
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2021-04-29 lsndxfj

#ROS#

41 0
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2021-04-29 ms1692212821629096

#胶质细胞#

46 0
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2021-04-28 1591fb2ef4m

牛叉

76 0
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2021-04-28 海1991

学习了

66 0
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2021-04-28 ms3000000626202845

心里永远的痛

79 0

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Nat Neurosci.：多发性硬化治疗新方向：小胶质细胞可以清除多发性硬化症中的有毒脂质

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