JAMA Surg:乳房植入相关的间变性大细胞淋巴瘤的特征及治疗

2017-10-25 zhangfan MedSci原创

乳房植入相关的间变性大细胞淋巴瘤是一种乳房假体植入相关的罕见癌症,但发病率正在上升。对于所有进行乳房假体植入手术的医生而言,了解植入体性质体并能够识别最初的疾病症状十分重要

乳房植入物相关的间变性大细胞淋巴瘤(BIA ALCL)是一种罕见的外周T细胞淋巴瘤,近年来发病率成上升趋势,对该疾病的认识仍十分有限。近日研究人员对BIA-ALCL的发生、风险因素、诊断以及后续治疗进行了综述。

总计304篇相关研究纳入本次综述,截止2017年1月,文献中报告了93个相关病例和2例非文献报告病例。所有的病例均与乳房植入物相关,其发病机制推测为慢性炎症感染导致得T细胞恶性转化,病理特征为间变性淋巴瘤激酶(ALK)阴性和CD30阳性。植入后到疾病症状的平均时间为10年。83名患者中,55人(66%)最初的体征为孤立迟发性血肿,7人(8%)为孤立的新发乳房肿块。疾病诊断主要依据超声检查与液体抽吸。治疗包括切除移植体和周围包膜,进一步的治疗手段包括化疗、放疗和淋巴结清除术。

乳房植入相关的间变性大细胞淋巴瘤是一种乳房假体植入相关的罕见癌症,但发病率正在上升。对于所有进行乳房假体植入手术的医生而言,了解植入体性质体并能够识别最初的疾病症状十分重要。

原始出处

Ashley N. Leberfinger et al. Breast Implant-Associated Anaplastic Large Cell Lymphoma A Systematic Review. JAMA Surg. October 18 2017.

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    2017-10-27 huangdf
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    2017-10-27 heli0118