Clin Exp Allergy:妊娠期糖基化终产物的摄入与后代过敏的关系

2021-10-19 AlexYang MedSci原创

调查了母亲AGEs摄入量与后代哮喘、喘息、特应性皮炎、过敏性鼻炎和食物过敏之间的关系,并尝试确定了AGEs的摄入量是否与脐带血清细胞因子/化学因子有关。

既往研究表明,糖基化终产物(AGEs)的膳食摄入量与儿童过敏性结果之间有关联

近期,来自美国的研究人员在《Clin Exp Allergy》上发表文章,调查了母亲AGEs摄入量与后代哮喘、喘息、特应性皮炎、过敏性鼻炎和食物过敏之间的关系,并尝试确定了AGEs的摄入量是否与脐带血清细胞因子/化学因子有关

研究招募了≥16岁的孕妇,为一个前瞻性出生前队列(N=1410)。分析包括了962对具有详细饮食和过敏结果的母子/女。通过怀孕期间24小时饮食回忆报告和食品AGEs值的参考数据库,估计了每位母亲的AGEs摄入量情况。从电子医疗记录中获得了8岁以下儿童的哮喘和过敏诊断结果,并对一部分儿童(N=462)的脐带血清细胞因子和趋化因子进行了分析。

结果发现,整个样本的AGEs摄入量中位数[IQR]为11919 kU/天[8293,16573]。未经调整的分析显示,母亲在怀孕期间的AGEs摄入量与8岁之前的鼻炎之间存在正相关关系(HR=1.03;95%CI:1.01,1.06),但调整后,该关联程度减弱,且无显著意义(HR=1.01;95%CI:0.98,1.04)。调整后和未调整的模型均显示妊娠期AGEs摄入量与其他任何结果之间没有关联(P>0.05)。测量的任何细胞因子或趋化因子与AGEs摄入量或任何研究结果之间没有明显的关联(P>0.05)。

AGE摄入与儿童过敏之间的关系情况

综上所述,母亲的AGEs摄入量与后代的哮喘和过敏结果没有关系。另外,怀孕期间的AGEs暴露与产后AGEs暴露可能对儿童的影响不一样

原始出处:

Carina Venter , Kaci Pickett , Anne Starling et al. Advanced glycation end product intake during pregnancy and offspring allergy outcomes: prospective cohort study. Clin Exp Allergy. Oct 2021

 

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    2021-10-20 ms4000000508774213

    糖基化终产物

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    2021-10-20 lfyang
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    2021-10-20 膀胱癌

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