Hum Reprod Update:子宫内膜异位症会增加患癌的风险

2015-03-18 MedSci MedSci原创

背景:尽管女性子宫内膜异位症患病率估计值为10 %,其病因机制仍然知之甚少。近十几年来,已发现子宫内膜异位症与多种慢性疾病的发生率有关,如癌症,自身免疫性疾病,哮喘/过敏性疾病和心血管疾病。需要对两者关联作进一步的深入研究,以期为子宫内膜异位症的原因与结局提供新的线索。本文是一篇综述性文章,用流行病学调查结果论述子宫内膜异位症和其他慢性疾病之间的关联,并讨论假设其基础机制,与潜在的偏见和方法的复杂

背景:


尽管女性子宫内膜异位症患病率估计值为10 %,其病因机制仍然知之甚少。近十几年来,已发现子宫内膜异位症与多种慢性疾病的发生率有关,如癌症,自身免疫性疾病,哮喘/过敏性疾病和心血管疾病。需要对两者关联作进一步的深入研究,以期为子宫内膜异位症的原因与结局提供新的线索。本文是一篇综述性文章,用流行病学调查结果论述子宫内膜异位症和其他慢性疾病之间的关联,并讨论假设其基础机制,与潜在的偏见和方法的复杂性来源。

方法:

我们通过检索2014年5月前PubMed、Medline 与 ISI上的所有有关子宫内膜异位症其他疾病之间关系的研究。我们还检查了所有已确定论文的参考文献目录,以捕捉那些没有通过计算机搜索发现任何其他文章。

结果:

我们确定了21项对子宫内膜异位症和卵巢癌之间关联的研究, 另外,14项与乳腺癌的关系,8项与子宫内膜癌的关系,4项与宫颈癌的关系,12项与皮肤黑色素瘤的关系,3项与非霍奇金淋巴瘤的关系,以及9项和自身免疫性疾病之间的联系,6项与哮喘和特应性疾病的联系,4项与心血管疾病的联系。据报道,子宫内膜异位症的患者患卵巢癌、乳腺癌、皮肤黑色素瘤、哮喘和某些自身免疫性、心血管和特应性疾病的风险较高,而患子宫颈癌的风险降低。

结论:

越来越多的证据表明,子宫内膜异位症患者患多种慢性疾病的风险升高。虽然其基本的机制尚未清楚。但根据现有数据最新显示,子宫内膜异位症对妇女的长期健康并不是无害的。如果子宫内膜异位症与这些疾病的关系得到证实,这些研究结果会在筛选方法和子宫内膜异位症患者的管理和护理上有重要的意义。

原始出处:

Kvaskoff, M., et al.Endometriosis: a high-risk population for major chronic diseases?.Hum Reprod Update.March 11, 2015.

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    2015-03-31 x35042875

    女性,羊膜腔内感染的

    0

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    2015-03-20 lq0307
  6. [GetPortalCommentsPageByObjectIdResponse(id=1708314, encodeId=cca41e08314aa, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Thu Aug 20 21:08:00 CST 2015, time=2015-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665600, encodeId=f59a166560063, content=<a href='/topic/show?id=685445152f6' target=_blank style='color:#2F92EE;'>#子宫内膜异位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45152, encryptionId=685445152f6, topicName=子宫内膜异位)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4de125981980, createdName=12498f17m74暂无昵称, createdTime=Sun Jul 19 20:08:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796597, encodeId=49ec1e9659734, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Mon Jun 15 05:08:00 CST 2015, time=2015-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19224, encodeId=e33a1922432, content=女性,羊膜腔内感染的, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:29:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601346, encodeId=53aa16013466f, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Fri Mar 20 10:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601737, encodeId=fe6c1601e37d1, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Mar 20 10:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=)]
    2015-03-20 sunylz

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