Sci Adc:人体试验已通过!长效避孕微针贴片,按压一分钟,有效一整月

2019-11-12 佚名 生物探索

是否可以存在一种像“创口贴”般的长效避孕贴片呢?

对于有性生活的女性来说,做好避孕措施是非常必要的。然而,最受欢迎的口服避孕药,不仅仅只能在短期内有效,还需要严格按时服用,不然则会导致意外怀孕事件发生……因此,越来越多的女性开始寻求长效的避孕手段。

目前市面上长效避孕的方法也是多种多样,如放置宫内节育器(也就是“上环”)、打孕激素注射针等。尽管避孕节育效果很好,但往往需要医疗专业人员的参与才能完成。

是否可以存在一种像“创口贴”般的长效避孕贴片呢?

美国乔治亚理工学院的Mark R. Prausnitz 教授及其团队依此灵感,设计出了一款长效避孕微针贴片,可通过带有微针的皮肤贴片安全有效地输送避孕药物左炔诺孕酮。最近,这一研究刚刚完成了人体试验,试验结果表明该贴片在人体体内也显示出强大的安全有效性,相关研究内容已于近日发表在《Science Advances》杂志上。

长效避孕微针贴片的极简设计

微针贴片技术被提出后,相继被应用于糖尿病,肥胖,脱发等生物医学领域,显示出了极大应用前景。研究第一作者、博士后研究人员Wei Li及其同事在此基础上拓展,将微针贴片应用于避孕领域。

长效避孕微针贴片上镶嵌着一块微针矩阵,其中包含100根600微米长,针尖直径不足10微米的微针。这些微针由生物降解材料制成,并封装避孕药物左炔诺孕酮。当其刺入皮肤时并不会存在明显的疼痛感觉。并轻松穿透皮肤的上层,释放被包裹的药物。




微针贴片的设计原理

此外,在贴片和微针之间,有一层由聚乙烯吡咯烷酮(PVP)、柠檬酸和碳酸氢钠组成的衬垫,当微针阵列刺入皮肤后,柠檬酸和碳酸氢钠便会在皮肤间质液(ISF)中发生泡腾反应,让微针自动脱落。简单来说,就像是当创可贴的吸附垫覆盖住伤口后,我们则需要将两端的塑料覆盖膜剥离,固定胶带位置一样。



避孕微针贴片脱离皮肤试验

贴片一分钟,有效一个月

为了验证避孕微针贴片在动物体内的有效性,研究人员首先选用了雌性大鼠作为试验对象。

在试验中,研究人员首先将封装避孕激素左炔诺孕酮的微针贴片手工压在其剃光毛的皮肤上,然后放置约1分钟。其次,观察发现,避孕微针在与皮肤接触后约几秒内便能有效与贴片膜分离,并嵌入皮肤表面持续释放药物。接着他们通过血浆内LNG浓度测量发现,药物持续释放时间可长达一个月且没有发生暴释现象。同时,皮肤实验部位没有出现红斑、水肿,意味着避孕微针贴片耐受性良好,不引起皮肤炎症反应。其研究内容已于今年1月发表在《Nature Biomedical Engineering》杂志上。

最新进展:人体试验确定有效性

既然在动物体内有着如此安全且有效的避孕效果,那是不是也同样适用于人类呢?于是,研究人员们又开始了关于人体试验的最新试验。

首先,研究人员挑选了10名育龄妇女作为研究对象。接着,将微针贴片贴在10位参与者的手背皮肤上并停留约1分钟,观察微针的自动分离、已经药物释放及其有效性等情况。



试验发现,98%的微针可以穿透皮肤,92%的微针能与贴片膜有效分离。并值得一提的是,在使用微针贴片时,10名参与者均报告称,与常规皮下注射相比,他们仅仅感到轻微的疼痛感,几乎是无痛。

此外,研究人员还发现,随着时间的推移,在人类参与者皮肤上红色斑块逐渐褪去,无红肿现象产生产生。并且根据皮肤染色显示,98%的微针能够有效穿透皮肤,并在此后长达一个月的时间里,也能在人体内安全有效地释放微针包裹的避孕药物。

领导该研究的Mark Prausnitz教授表示:“我们可以乐观地认为这种贴剂将成为一种有效的避孕手段。我们期望将它对皮肤的刺激降到最低,但是这些预期需要在临床试验中得到了验证。”

如果微针避孕贴最终被批准使用,那么它可能成为第一种不含常规针头注射的自我施用的长效避孕手段。但值得注意地是,和其它长效避孕技术一样,“微针避孕贴片”也有可能会扰乱使用者的月经周期。

原始出处:

Wei Li et al. Long-acting reversible contraception by effervescent microneedle patch, Science Advances (2019). DOI: 10.1126/sciadv.aaw8145.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1651268, encodeId=6b4016512684e, content=<a href='/topic/show?id=6f9c564499c' target=_blank style='color:#2F92EE;'>#按压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56449, encryptionId=6f9c564499c, topicName=按压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a7424147894, createdName=lisa446, createdTime=Sat Mar 28 21:56:00 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016056, encodeId=17132016056c0, content=<a href='/topic/show?id=d4a95082e62' target=_blank style='color:#2F92EE;'>#微针贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50827, encryptionId=d4a95082e62, topicName=微针贴片)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Fri May 22 16:56:00 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764166, encodeId=b5d31e641668c, content=<a href='/topic/show?id=844492480bb' target=_blank style='color:#2F92EE;'>#贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92480, encryptionId=844492480bb, topicName=贴片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56f237637156, createdName=12498b37m84暂无昵称, createdTime=Sat Jan 25 04:56:00 CST 2020, time=2020-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513640, encodeId=14751513640b6, content=<a href='/topic/show?id=c41924e0391' target=_blank style='color:#2F92EE;'>#人体试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24703, encryptionId=c41924e0391, topicName=人体试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9ab10580029, createdName=ms5906905816781247, createdTime=Thu Nov 14 05:56:00 CST 2019, time=2019-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375126, encodeId=67593e51265f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Wed Nov 13 19:05:08 CST 2019, time=2019-11-13, status=1, ipAttribution=)]
    2020-03-28 lisa446
  2. [GetPortalCommentsPageByObjectIdResponse(id=1651268, encodeId=6b4016512684e, content=<a href='/topic/show?id=6f9c564499c' target=_blank style='color:#2F92EE;'>#按压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56449, encryptionId=6f9c564499c, topicName=按压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a7424147894, createdName=lisa446, createdTime=Sat Mar 28 21:56:00 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016056, encodeId=17132016056c0, content=<a href='/topic/show?id=d4a95082e62' target=_blank style='color:#2F92EE;'>#微针贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50827, encryptionId=d4a95082e62, topicName=微针贴片)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Fri May 22 16:56:00 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764166, encodeId=b5d31e641668c, content=<a href='/topic/show?id=844492480bb' target=_blank style='color:#2F92EE;'>#贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92480, encryptionId=844492480bb, topicName=贴片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56f237637156, createdName=12498b37m84暂无昵称, createdTime=Sat Jan 25 04:56:00 CST 2020, time=2020-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513640, encodeId=14751513640b6, content=<a href='/topic/show?id=c41924e0391' target=_blank style='color:#2F92EE;'>#人体试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24703, encryptionId=c41924e0391, topicName=人体试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9ab10580029, createdName=ms5906905816781247, createdTime=Thu Nov 14 05:56:00 CST 2019, time=2019-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375126, encodeId=67593e51265f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Wed Nov 13 19:05:08 CST 2019, time=2019-11-13, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1651268, encodeId=6b4016512684e, content=<a href='/topic/show?id=6f9c564499c' target=_blank style='color:#2F92EE;'>#按压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56449, encryptionId=6f9c564499c, topicName=按压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a7424147894, createdName=lisa446, createdTime=Sat Mar 28 21:56:00 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016056, encodeId=17132016056c0, content=<a href='/topic/show?id=d4a95082e62' target=_blank style='color:#2F92EE;'>#微针贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50827, encryptionId=d4a95082e62, topicName=微针贴片)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Fri May 22 16:56:00 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764166, encodeId=b5d31e641668c, content=<a href='/topic/show?id=844492480bb' target=_blank style='color:#2F92EE;'>#贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92480, encryptionId=844492480bb, topicName=贴片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56f237637156, createdName=12498b37m84暂无昵称, createdTime=Sat Jan 25 04:56:00 CST 2020, time=2020-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513640, encodeId=14751513640b6, content=<a href='/topic/show?id=c41924e0391' target=_blank style='color:#2F92EE;'>#人体试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24703, encryptionId=c41924e0391, topicName=人体试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9ab10580029, createdName=ms5906905816781247, createdTime=Thu Nov 14 05:56:00 CST 2019, time=2019-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375126, encodeId=67593e51265f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Wed Nov 13 19:05:08 CST 2019, time=2019-11-13, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1651268, encodeId=6b4016512684e, content=<a href='/topic/show?id=6f9c564499c' target=_blank style='color:#2F92EE;'>#按压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56449, encryptionId=6f9c564499c, topicName=按压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a7424147894, createdName=lisa446, createdTime=Sat Mar 28 21:56:00 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016056, encodeId=17132016056c0, content=<a href='/topic/show?id=d4a95082e62' target=_blank style='color:#2F92EE;'>#微针贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50827, encryptionId=d4a95082e62, topicName=微针贴片)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Fri May 22 16:56:00 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764166, encodeId=b5d31e641668c, content=<a href='/topic/show?id=844492480bb' target=_blank style='color:#2F92EE;'>#贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92480, encryptionId=844492480bb, topicName=贴片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56f237637156, createdName=12498b37m84暂无昵称, createdTime=Sat Jan 25 04:56:00 CST 2020, time=2020-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513640, encodeId=14751513640b6, content=<a href='/topic/show?id=c41924e0391' target=_blank style='color:#2F92EE;'>#人体试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24703, encryptionId=c41924e0391, topicName=人体试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9ab10580029, createdName=ms5906905816781247, createdTime=Thu Nov 14 05:56:00 CST 2019, time=2019-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375126, encodeId=67593e51265f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Wed Nov 13 19:05:08 CST 2019, time=2019-11-13, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1651268, encodeId=6b4016512684e, content=<a href='/topic/show?id=6f9c564499c' target=_blank style='color:#2F92EE;'>#按压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56449, encryptionId=6f9c564499c, topicName=按压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a7424147894, createdName=lisa446, createdTime=Sat Mar 28 21:56:00 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016056, encodeId=17132016056c0, content=<a href='/topic/show?id=d4a95082e62' target=_blank style='color:#2F92EE;'>#微针贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50827, encryptionId=d4a95082e62, topicName=微针贴片)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Fri May 22 16:56:00 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764166, encodeId=b5d31e641668c, content=<a href='/topic/show?id=844492480bb' target=_blank style='color:#2F92EE;'>#贴片#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92480, encryptionId=844492480bb, topicName=贴片)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56f237637156, createdName=12498b37m84暂无昵称, createdTime=Sat Jan 25 04:56:00 CST 2020, time=2020-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513640, encodeId=14751513640b6, content=<a href='/topic/show?id=c41924e0391' target=_blank style='color:#2F92EE;'>#人体试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24703, encryptionId=c41924e0391, topicName=人体试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9ab10580029, createdName=ms5906905816781247, createdTime=Thu Nov 14 05:56:00 CST 2019, time=2019-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375126, encodeId=67593e51265f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Wed Nov 13 19:05:08 CST 2019, time=2019-11-13, status=1, ipAttribution=)]
    2019-11-13 一个字-牛

    学习了谢谢分享

    0

相关资讯

2017 女性缺血性脑卒中后不孕,避孕以及更年期激素治疗共识

该专家共识的主要目的是指导缺血性脑卒中后女性患者激素和妊娠的终身管理,提供了卒中后妇女妊娠、避孕和激素替代疗法的相关内容。该共识提示,临床上卒中后妇女需要神经科、妇科和内分泌科专家的协力管理。

Nature Biomedical Engineering:每月5秒钟,新型皮肤贴片提供长效避孕

对于有性生活的女性来说,避孕措施是非常必要的,但用于避孕的手段很有限。屏障方法的接受度低,而且会因使用不当而导致意外怀孕;比较流行的是口服避孕药,但也只能在短期内有效。因此,越来越多的女性开始寻求长效的避孕手段。现有的长效避孕药具有高水平的有效性,但通常需要医疗保健专业人员操作注射药物或植入物。近日,美国乔治亚理工学院的研究人员开发出一种新技术,可以让女性在几秒钟内“自行操作”长效避孕药。该技术通

Lancet:醋酸甲羟孕酮、宫内节育器或乙羟基二降孕甾烯炔酮避孕人群的HIV感染风险

研究发现,采用注射醋酸甲羟孕酮、宫内节育器或乙羟基二降孕甾烯炔酮避孕人群的HIV感染风险无显著差异

我国每年人工流产900多万例 卫健委发布避孕服务规范

国家卫健委日前印发关于《人工流产后避孕服务规范(2018版)》(以下简称《规范》)及其解读,为接受人工流产的女性如何高效避孕、减少重复流产、促进计划妊娠等制定了指导规范。中国每年人工流产约900多万例为何高发?选择人工流产的群体在中国并不少见。《规范》中披露,近年来中国人工流产数量大,每年约900多万例。接受人工流产手术的女性中低龄者、未育者占比大,重复人流比例高。卫健委在对《规范》文件进行解读

专门由男性服用的避孕药新鲜出炉!

假如市面出现 一款安全、有效的男性避孕药, 你或者你老公愿意吃吗?

人工流产后避孕服务规范(2018版)

人工流产是非意愿妊娠后采取的补救措施。人工流产对女性生育能力和生殖健康损害严重,可能导致多种并发症和继发不孕,重复人工流产发生并发症和继发不孕风险更高。 为推进人工流产后即时落实高效避孕节育措施,切实减少重复人工流产,保障女性生育能力和身心健康,中华人民共和国国家卫生健康委员会组织制定了《人工流产后避孕服务规范(2018版)》。