Am J Clin Nutr: 每天吃一个苹果可减少肥胖患者的炎症生物标志物水平

2021-05-10 MedSci原创 MedSci原创

超重和肥胖影响着全球约52%的成年人,超重和肥胖会导致全身的慢性低度炎症,循环炎症生物标志物C反应蛋白(CRP)明显升高。

      超重和肥胖影响着全球约52%的成年人,超重和肥胖会导致全身的慢性低度炎症,循环炎症生物标志物C反应蛋白(CRP)明显升高,并且当指标≥3.0 mg / mL时患血管疾病(CVD)的风险明显升高。苹果是全球最常食用的水果之一,富含抗炎生物活性物质,包括多酚和纤维。定期食用苹果与CRP呈反比关系。每天摄入超过138 g(约2个)完整苹果可以降低CRP升高的风险。事实上,流行病学证据也支持常规的苹果消费可以减少心血管疾病及其他死亡的发生。因此,本项研究旨在探讨超重和肥胖的人日常饮食中每天摄入苹果作为习惯饮食的一部分是否会导致血浆(主要结局)和外周血单个核细胞(PBMC)中炎症生物标志物的浓度降低。

 

      研究人员对46名参与者进行了随机,对照试验。在连续2周避免食用富含多酚和纤维的食物和饮料后,23名参与者每天食用3个完整的苹果(约200 g可食用部分)以及23名避免食用苹果的对照组。在6周的试验中,所有参与者都限制了多酚和纤维的食用。在6周之前和之后收集空腹血液样品,用于血浆生物标志物的分析和PBMC的分离,并将PBMC在未刺激或LPS(10 ng / mL)刺激下培养24小时。

 

      总共有44名参与者完成了试验(30名女性,14名男性; BMI:33.4±0.9 kg/m2)。经过ANCOVA校正并进行多次比较后,苹果使患者空腹血浆C反应蛋白降低了17.0%(P =  0.005),IL-6降低了12.4%(P < 0.001)。苹果还将PBMC分泌的IL-6降低了28.3%(P < 0.001)和IL-17降低了11.0%(P = 0.003)。探索性分析显示, 与对照组相比,苹果还使血浆总抗氧化能力提高了9.6%(P = 0.002)。但是,苹果对人体测量学或其他CVD风险指标没有影响。

图:苹果对于机体炎症指标的影响

       本项研究证实每天食用一个苹果可减轻肥胖相关的炎症,而且可以间接降低CVD的风险,且不会造成体重减轻。

 

 

 

原始出处:

Danyelle M Liddle. Et al. Daily apple consumption reduces plasma and peripheral blood mononuclear cell–secreted inflammatory biomarkers in adults with overweight and obesity: a 6-week randomized, controlled, parallel-arm trial. The American Journal of Clinical Nutrition.2021.

 

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    2021-05-17 124902dfm95暂无昵称

    每天2个苹果,让疾病远离我

    0

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    2021-05-12 okhuali
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    2021-05-10 T2DM终结者

    Two apples a day keeps the doctor away~

    0

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