J Periodontol:全口消毒对严重慢性牙周炎龈沟液中相关蛋白表达水平的影响

2020-02-06 lishiting MedSci原创

这篇研究的目的是为了比较和评估全口消毒(FMD)和全口超声洁治(FMUD)对严重慢性牙周炎常规象限法龈下刮治及根面平整(Q-SRP)的临床、微生物以及生物化学指标的影响。

这篇研究的目的是为了比较和评估全口消毒(FMD)和全口超声洁治(FMUD)对严重慢性牙周炎常规象限法龈下刮治及根面平整(Q-SRP)的临床、微生物以及生物化学指标的影响。

这篇预期的临床随机对照试验纳入了60名慢性牙周炎患者,并将其按照顺序随机分为3个试验组:FMD (n = 20), FMUD (n = 20)和Q-SRP (n = 20)。所有的检测和治疗均为相同的操作者完成。治疗前,收集患者的龈沟液(GCF)和龈下菌斑,并记录临床牙周指标。在FMD和FMUD组,超声清创在24小时内完成。FMD组使用葡萄糖氯己定。通过手用器械每隔一周洁治一个象限完成Q-SRP。在治疗后的1, 3和6个月进行检测和收集样本。Real-time PCR定量分析放线共生放线杆菌、牙龈卟啉单胞菌、中间普雷沃菌、福赛斯坦纳菌、具核梭杆菌和总菌数量。通过ELISA检测GCF中钙结合蛋白、骨钙素和I型胶原蛋白氨基端肽(NTx)的表达水平。

结果显示,各组间治疗后GCF中生物标记物表达水平的变化为主要转归。各组间未见损伤。所有治疗策略对于临床指标均有显著性改善(p<0.05),各组在所有时间点均无明显差异(p?0.05)。术后6个月,与FMUD和Q-SRP组相比,FMD组中放线共生放线杆菌显著减少(p<0.05)。尽管GCF中NTx的总量在研究周期内的所有实验组中均上升,但是这个增加在治疗后所有检测时间点的全口组中并不明显(p<0.05)。

结论:这篇研究展现的是治疗的短期效果。全口治疗方法对于象限法后的微生物和生物化学指标的作用有限。3种策略均可应用于严重慢性牙周炎的治疗中。

原始出处:

Beral Afacan, Serhat Çinarcik, et al. The Effects of Full-Mouth Disinfection on Gingival Crevicular Fluid Levels of Calprotectin, Osteocalcin and N-telopeptide of Type I Collagen in Severe Chronic Periodontitis. J Periodontol,  2020 Feb 5[Online ahead of print] PMID: 32023661  DOI: 10.1002/JPER.19-0445

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    2020-07-13 feather89
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    2020-02-08 huperzia
  8. [GetPortalCommentsPageByObjectIdResponse(id=1686896, encodeId=5a581686896c9, content=<a href='/topic/show?id=1fc71035e1c1' target=_blank style='color:#2F92EE;'>#龈沟液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103571, encryptionId=1fc71035e1c1, topicName=龈沟液)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0fa428300788, createdName=ms8435843352634314, createdTime=Wed Jul 08 01:51:00 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728288, encodeId=861f1e2828825, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Jul 13 20:51:00 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2010842, encodeId=283c201084213, content=<a href='/topic/show?id=aa0029324f4' target=_blank style='color:#2F92EE;'>#全口消毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29324, encryptionId=aa0029324f4, topicName=全口消毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Fri Nov 06 05:51:00 CST 2020, time=2020-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990176, encodeId=844c19901e60d, content=<a href='/topic/show?id=c6c0902e456' target=_blank style='color:#2F92EE;'>#表达水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90274, encryptionId=c6c0902e456, topicName=表达水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Sat Jun 06 15:51:00 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368689, encodeId=6a8613686898a, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Sat Feb 08 04:51:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451190, encodeId=5d66145119023, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Feb 08 04:51:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489445, encodeId=31111489445fc, content=<a href='/topic/show?id=a66865e9926' target=_blank style='color:#2F92EE;'>#消毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65799, encryptionId=a66865e9926, topicName=消毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=71d48549435, createdName=huperzia, createdTime=Sat Feb 08 04:51:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532667, encodeId=26fc153266ef0, content=<a href='/topic/show?id=f33388695c2' target=_blank style='color:#2F92EE;'>#蛋白表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88695, encryptionId=f33388695c2, topicName=蛋白表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79512374813, createdName=xuyu, createdTime=Sat Feb 08 04:51:00 CST 2020, time=2020-02-08, status=1, ipAttribution=)]
    2020-02-08 xuyu

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