J Clin Periodontol:慢性牙周炎对人多形核白细胞-内皮细胞相互作用及氧化应激的影响

2018-12-22 MedSci MedSci原创

本文旨在根据疾病的严重程度,评估慢性牙周炎(CP)患者多形核白细胞(PMNs)氧化应激参数与PMN-内皮细胞相互作用之间的关系。

本文旨在根据疾病的严重程度,评估慢性牙周炎(CP)患者多形核白细胞(PMNs)氧化应激参数与PMN-内皮细胞相互作用之间的关系。

材料和方法:对于这项横断面研究,根据CP的程度将182名受试者分为四组:无CP(n = 37),轻度CP(n = 59),中度CP(n = 51)和重度CP(n = 35)。本文确定了人体测量和生化变量,牙周参数,炎症标志物,氧化应激参数(超氧化物和线粒体膜电位)和PMN-内皮细胞相互作用(滚动通量,速度和粘附)。

结果:CP组中系统性炎症标志物-C-反应蛋白,白细胞计数,TNFα和视黄醇结合蛋白4有改变。中重度牙周炎患者的总超氧化物含量增加,而线粒体膜电位没有变化。此外,CP患者的PMNs粘附和滚动通量增加。

在全身炎症环境中,CP患者的PMN表现出活动过度并产生更高量的超氧化物。与此同时,PMNs滚动通量和细胞粘附到内皮的增加表明CP患者中PMN-内皮相互作用的改变可导致动脉粥样硬化和血管并发症。

原始出处:

Mayte Martinez‐Herrera,et al.Chronic periodontitis impairs polymorphonuclear leucocyte–endothelium cell interactions and oxidative stress in humans.Journal of  Clinical Periodontology.2018 Decemember. Doi:10.1111/jcpe.13027

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    2018-12-24 ylz8405
  7. [GetPortalCommentsPageByObjectIdResponse(id=1727789, encodeId=cc571e2778996, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Mar 02 11:15:00 CST 2019, time=2019-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909275, encodeId=1c0d19092e5e5, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Sat Mar 09 12:15:00 CST 2019, time=2019-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368678, encodeId=003b13686e81f, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Mon Dec 24 12:15:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445260, encodeId=19ef1445260d3, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79df5138909, createdName=ms1260584454294838, createdTime=Mon Dec 24 12:15:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451080, encodeId=d31b1451080fe, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Dec 24 12:15:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471625, encodeId=f14014e1625d6, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Mon Dec 24 12:15:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356129, encodeId=b41a356129f3, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat Dec 22 22:25:41 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356120, encodeId=2347356120c1, content=好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Dec 22 21:45:57 CST 2018, time=2018-12-22, status=1, ipAttribution=)]
    2018-12-22 天地飞扬

    了解一下,谢谢分享!

    0

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    2018-12-22 1dd8a7c5m95(暂无匿称)

    好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!

    0

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