Dent Mater J:铜/氢氧化钙类根管糊剂对金葡菌、铜绿假单胞菌和白念菌的抗菌和抗生物膜活性

2019-07-18 lishiting MedSci原创

牙髓生物膜是一个微生物群落,它附着在含有病原体的多糖来源聚合物基质内,如:能够引起多种牙髓病理表现的细菌和机会真菌。而对于临床更重要的是,生物膜的存在会极度抑制常规根管冲洗、抗菌药物和宿主的免疫反应。因此,这篇研究的目的是为了体外评估Cu/CaOH2类的根管糊剂对细菌和真菌的功效,如金葡菌、铜绿假单胞菌和白念菌。

牙髓生物膜是一个微生物群落,它附着在含有病原体的多糖来源聚合物基质内,如:能够引起多种牙髓病理表现的细菌和机会真菌。而对于临床更重要的是,生物膜的存在会极度抑制常规根管冲洗、抗菌药物和宿主的免疫反应。因此,这篇研究的目的是为了体外评估Cu/CaOH2类的根管糊剂对细菌和真菌的功效,如金葡菌、铜绿假单胞菌和白念菌。

结果显示,这种复合物显著减少微生物的复制时间和细胞生长。并且,生物膜的形成和持久性也受到影响;施加处理的生物膜也表现出细胞数量和浓绿素水平的明显降低。

结论:这篇研究首次证实了这种牙髓复合物抗细菌生物膜的有效性。鉴于其作用的广泛性,可以考虑将其用于预防和治疗主要口腔生物膜相关的感染

原始出处:


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  7. [GetPortalCommentsPageByObjectIdResponse(id=1800092, encodeId=c4c61800092a6, content=<a href='/topic/show?id=0d06e16869e' target=_blank style='color:#2F92EE;'>#白念菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71686, encryptionId=0d06e16869e, topicName=白念菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Sun Mar 29 14:36:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974299, encodeId=bee819e429997, content=<a href='/topic/show?id=fc6c9622148' target=_blank style='color:#2F92EE;'>#金葡菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96221, encryptionId=fc6c9622148, topicName=金葡菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Fri May 22 21:36:00 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1940839, encodeId=2a5e1940839e6, content=<a href='/topic/show?id=199e554181d' target=_blank style='color:#2F92EE;'>#抗生物膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55418, encryptionId=199e554181d, topicName=抗生物膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ed3112, createdName=echonoir, createdTime=Sat Jan 11 17:36:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330839, encodeId=d4d0133083904, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sat Jul 20 03:36:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522967, encodeId=e135152296e74, content=<a href='/topic/show?id=c72462241ff' target=_blank style='color:#2F92EE;'>#根管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62241, encryptionId=c72462241ff, topicName=根管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba5e11492705, createdName=zhaozhouchifen, createdTime=Sat Jul 20 03:36:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569929, encodeId=66fc1569929c2, content=<a href='/topic/show?id=e14a6395908' target=_blank style='color:#2F92EE;'>#氢氧化钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63959, encryptionId=e14a6395908, topicName=氢氧化钙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f8f315601930, createdName=tongyongming, createdTime=Sat Jul 20 03:36:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369887, encodeId=b21536988ead, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Thu Jul 18 14:21:53 CST 2019, time=2019-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369879, encodeId=64183698e943, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jul 18 12:41:03 CST 2019, time=2019-07-18, status=1, ipAttribution=)]
    2019-07-18 phoebeyan520

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1800092, encodeId=c4c61800092a6, content=<a href='/topic/show?id=0d06e16869e' target=_blank style='color:#2F92EE;'>#白念菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71686, encryptionId=0d06e16869e, topicName=白念菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Sun Mar 29 14:36:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974299, encodeId=bee819e429997, content=<a href='/topic/show?id=fc6c9622148' target=_blank style='color:#2F92EE;'>#金葡菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96221, encryptionId=fc6c9622148, topicName=金葡菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Fri May 22 21:36:00 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1940839, encodeId=2a5e1940839e6, content=<a href='/topic/show?id=199e554181d' target=_blank style='color:#2F92EE;'>#抗生物膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55418, encryptionId=199e554181d, topicName=抗生物膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ed3112, createdName=echonoir, createdTime=Sat Jan 11 17:36:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330839, encodeId=d4d0133083904, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sat Jul 20 03:36:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522967, encodeId=e135152296e74, content=<a href='/topic/show?id=c72462241ff' target=_blank style='color:#2F92EE;'>#根管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62241, encryptionId=c72462241ff, topicName=根管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba5e11492705, createdName=zhaozhouchifen, createdTime=Sat Jul 20 03:36:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569929, encodeId=66fc1569929c2, content=<a href='/topic/show?id=e14a6395908' target=_blank style='color:#2F92EE;'>#氢氧化钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63959, encryptionId=e14a6395908, topicName=氢氧化钙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f8f315601930, createdName=tongyongming, createdTime=Sat Jul 20 03:36:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369887, encodeId=b21536988ead, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Thu Jul 18 14:21:53 CST 2019, time=2019-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369879, encodeId=64183698e943, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Jul 18 12:41:03 CST 2019, time=2019-07-18, status=1, ipAttribution=)]
    2019-07-18 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0