JTO:阿司匹林、他汀类药物和二甲双胍与肺癌风险和相关死亡率的关系

2020-10-07 MedSci原创 MedSci原创

本研究的目的是使用基于人群的全国队列数据研究阿司匹林,二甲双胍和他汀类药物与肺癌风险和死亡率的关系。

本研究的目的是使用基于人群的全国队列数据研究阿司匹林,二甲双胍和他汀类药物与肺癌风险和死亡率的关系。

本研究共纳入732,199名2002-2003年接受国家健康检查的参与者。使用注册的肺癌诊断代码(ICD-10代码C34)和韩国国家死亡登记处确定肺癌的发病率和死亡率。自2004年1月1日至2013年12月31日对研究参与者进行随访。药物的暴露量由累积使用时间和每2年间隔累积定义的每日剂量(cDDD)定义。为了避免出现时间偏差,在Cox分析中将药物暴露作为时间依赖性变量评估,该变量评估了这些药物与肺癌之间的关联。

二甲双胍的使用与肺癌发生率(趋势P = 0.008)和死亡率(趋势P <0.001)呈剂量反应关系,并且在二甲双胍cDDD≥的参与者中这些关联尤为明显。,这些关系在二甲双胍cDDD≥547.5的参与者中较非糖尿病患者显著。使用阿司匹林(P, 0.046)和他汀类药物(P <0.001)可降低肺癌死亡率。联合使用阿司匹林、他汀类药物和二甲双胍对肺癌风险和死亡率有更显著的保护作用。

阿司匹林,二甲双胍和他汀类药物的使用与肺癌死亡率具有独立的保护性关联,二甲双胍与肺癌的风险呈负相关。有必要进行进一步的研究以开发这些药物的临床适用的抗癌策略,以降低肺癌和相关死亡率。

原始出处:

Kang J, Jeong SM, Shin DW, Cho M, Cho JH, Kim J. Associations of aspirin, statins, and metformin with lung cancer risk and related mortality: time-dependent analysis of population-based nationally representative data. J Thorac Oncol . 2020 Sep 12;S1556-0864(20)30712-7.

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    2021-04-30 MedSciZeng

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  2. [GetPortalCommentsPageByObjectIdResponse(id=961951, encodeId=6f1c961951d9, content=<a href='/topic/show?id=e73d1042656b' target=_blank style='color:#2F92EE;'>#JTO#</a>点击进入话题查看更多相关文章 或评论时插入话题加入讨论, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104265, encryptionId=e73d1042656b, topicName=JTO)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:45:32 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045577, encodeId=605520455e75b, content=<a href='/topic/show?id=f6cf8225325' target=_blank style='color:#2F92EE;'>#肺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82253, encryptionId=f6cf8225325, topicName=肺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Sat Oct 31 09:18:24 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899478, encodeId=1f828994e8c7, content=<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>,<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>和<a href='/topic/show?id=19da25343bd' target=_blank style='color:#2F92EE;'>#他汀类#</a>药物的使用与<a href='/topic/show?id=384b8220449' target=_blank style='color:#2F92EE;'>#肺癌#</a>死亡率具有独立的保护性关联,二甲双胍与肺癌的风险呈负相关。阿司匹林具有预防肿瘤的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=219, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林), TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍), TopicDto(id=25343, encryptionId=19da25343bd, topicName=他汀类), TopicDto(id=82204, encryptionId=384b8220449, topicName=肺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 16 08:42:29 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044591, encodeId=a0682044591e2, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sat Jan 02 23:18:24 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061967, encodeId=7bfe206196e36, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Aug 03 20:18:24 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890558, encodeId=4f30890558c0, content=好神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200810/413f8b33b4e34dcd82cbfc3ffd0f8c3c/4393e48ea913472084d5677670d3b48b.jpg, createdBy=b52c5409947, createdName=ms1000000223698072, createdTime=Wed Oct 07 19:49:10 CST 2020, time=2020-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041557, encodeId=ce54104155e9b, content=二甲双胍,神药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 07 19:18:24 CST 2020, time=2020-10-07, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=961951, encodeId=6f1c961951d9, content=<a href='/topic/show?id=e73d1042656b' target=_blank style='color:#2F92EE;'>#JTO#</a>点击进入话题查看更多相关文章 或评论时插入话题加入讨论, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104265, encryptionId=e73d1042656b, topicName=JTO)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:45:32 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045577, encodeId=605520455e75b, content=<a href='/topic/show?id=f6cf8225325' target=_blank style='color:#2F92EE;'>#肺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82253, encryptionId=f6cf8225325, topicName=肺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Sat Oct 31 09:18:24 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899478, encodeId=1f828994e8c7, content=<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>,<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>和<a href='/topic/show?id=19da25343bd' target=_blank style='color:#2F92EE;'>#他汀类#</a>药物的使用与<a href='/topic/show?id=384b8220449' target=_blank style='color:#2F92EE;'>#肺癌#</a>死亡率具有独立的保护性关联,二甲双胍与肺癌的风险呈负相关。阿司匹林具有预防肿瘤的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=219, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林), TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍), TopicDto(id=25343, encryptionId=19da25343bd, topicName=他汀类), TopicDto(id=82204, encryptionId=384b8220449, topicName=肺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 16 08:42:29 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044591, encodeId=a0682044591e2, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sat Jan 02 23:18:24 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061967, encodeId=7bfe206196e36, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Aug 03 20:18:24 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890558, encodeId=4f30890558c0, content=好神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200810/413f8b33b4e34dcd82cbfc3ffd0f8c3c/4393e48ea913472084d5677670d3b48b.jpg, createdBy=b52c5409947, createdName=ms1000000223698072, createdTime=Wed Oct 07 19:49:10 CST 2020, time=2020-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041557, encodeId=ce54104155e9b, content=二甲双胍,神药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 07 19:18:24 CST 2020, time=2020-10-07, status=1, ipAttribution=)]
    2020-11-16 lovetcm

    #阿司匹林##二甲双胍##他汀类#药物的使用与#肺癌#死亡率具有独立的保护性关联,二甲双胍与肺癌的风险呈负相关。阿司匹林具有预防肿瘤的作用

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=961951, encodeId=6f1c961951d9, content=<a href='/topic/show?id=e73d1042656b' target=_blank style='color:#2F92EE;'>#JTO#</a>点击进入话题查看更多相关文章 或评论时插入话题加入讨论, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104265, encryptionId=e73d1042656b, topicName=JTO)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:45:32 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045577, encodeId=605520455e75b, content=<a href='/topic/show?id=f6cf8225325' target=_blank style='color:#2F92EE;'>#肺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82253, encryptionId=f6cf8225325, topicName=肺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Sat Oct 31 09:18:24 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899478, encodeId=1f828994e8c7, content=<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>,<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>和<a href='/topic/show?id=19da25343bd' target=_blank style='color:#2F92EE;'>#他汀类#</a>药物的使用与<a href='/topic/show?id=384b8220449' target=_blank style='color:#2F92EE;'>#肺癌#</a>死亡率具有独立的保护性关联,二甲双胍与肺癌的风险呈负相关。阿司匹林具有预防肿瘤的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=219, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林), TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍), TopicDto(id=25343, encryptionId=19da25343bd, topicName=他汀类), TopicDto(id=82204, encryptionId=384b8220449, topicName=肺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 16 08:42:29 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044591, encodeId=a0682044591e2, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sat Jan 02 23:18:24 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061967, encodeId=7bfe206196e36, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Aug 03 20:18:24 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890558, encodeId=4f30890558c0, content=好神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200810/413f8b33b4e34dcd82cbfc3ffd0f8c3c/4393e48ea913472084d5677670d3b48b.jpg, createdBy=b52c5409947, createdName=ms1000000223698072, createdTime=Wed Oct 07 19:49:10 CST 2020, time=2020-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041557, encodeId=ce54104155e9b, content=二甲双胍,神药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 07 19:18:24 CST 2020, time=2020-10-07, status=1, ipAttribution=)]
    2020-10-07 ms1000000223698072

    好神奇

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=961951, encodeId=6f1c961951d9, content=<a href='/topic/show?id=e73d1042656b' target=_blank style='color:#2F92EE;'>#JTO#</a>点击进入话题查看更多相关文章 或评论时插入话题加入讨论, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104265, encryptionId=e73d1042656b, topicName=JTO)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:45:32 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045577, encodeId=605520455e75b, content=<a href='/topic/show?id=f6cf8225325' target=_blank style='color:#2F92EE;'>#肺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82253, encryptionId=f6cf8225325, topicName=肺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Sat Oct 31 09:18:24 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899478, encodeId=1f828994e8c7, content=<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>,<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>和<a href='/topic/show?id=19da25343bd' target=_blank style='color:#2F92EE;'>#他汀类#</a>药物的使用与<a href='/topic/show?id=384b8220449' target=_blank style='color:#2F92EE;'>#肺癌#</a>死亡率具有独立的保护性关联,二甲双胍与肺癌的风险呈负相关。阿司匹林具有预防肿瘤的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=219, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林), TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍), TopicDto(id=25343, encryptionId=19da25343bd, topicName=他汀类), TopicDto(id=82204, encryptionId=384b8220449, topicName=肺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 16 08:42:29 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044591, encodeId=a0682044591e2, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sat Jan 02 23:18:24 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061967, encodeId=7bfe206196e36, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Aug 03 20:18:24 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890558, encodeId=4f30890558c0, content=好神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200810/413f8b33b4e34dcd82cbfc3ffd0f8c3c/4393e48ea913472084d5677670d3b48b.jpg, createdBy=b52c5409947, createdName=ms1000000223698072, createdTime=Wed Oct 07 19:49:10 CST 2020, time=2020-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041557, encodeId=ce54104155e9b, content=二甲双胍,神药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 07 19:18:24 CST 2020, time=2020-10-07, status=1, ipAttribution=)]
    2020-10-07 misszhang

    二甲双胍,神药!

    0

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Br J Cancer:新型PPARγ激动剂CB11:非小细胞肺癌的潜在治疗药物

肺癌是全球癌症相关死亡的最常见原因,包括两种类型:小细胞肺癌(SCLC)和非小细胞肺癌(NSCLC)。既往研究显示,PPARγ(过氧化物酶体增殖物激活受体γ)激动剂能诱导人非小

Nat Commun:奥希替尼配合耐药信号抑制明显改善EGFR突变型肺癌的预后

肺癌是全球范围内癌症相关死亡的主要原因之一,非小细胞肺癌(NSCLC)占肺癌的85%。包括抗PD-1抗体和抗PD-L1抗体在内的免疫检查点抑制剂(ICIs)已获准用于晚期NSCLC的治疗,且已证实该治

FDA批准Gavreto(pralsetinib)治疗转移性RET融合阳性非小细胞肺癌

罗氏集团成员Genentech今天宣布,美国食品药品监督管理局(FDA)已批准Gavreto™(pralsetinib)用于治疗转移性RET融合阳性非小细胞肺癌(NSCLC)患者。

Lancet Oncol:纳武单抗新辅助免疫化疗大大改善可切除非小细胞肺癌的预后

大多数非小细胞肺癌(NSCLC)患者确诊时已是终末期,即局部晚期。本研究旨在评估新辅助化学免疫疗法对可切除的IIIA期NSCLC患者的抗肿瘤活性和安全性。

CAN04联合pembrolizumab治疗多种肿瘤:I期临床研究正在进行中

制药公司Cantargia今天宣布,在美国进行的I期临床试验中,首位患者已开始使用抗体CAN04和pembrolizumab进行治疗,该试验将根据临床方案继续进行。