Gastroenterology:苯扎贝特可以有效治疗纤维化胆管病中的瘙痒症状

2020-10-16 MedSci原创 MedSci原创

患有原发性或继发性硬化性胆管炎(PSC,SSC)和原发性胆汁性胆管炎(PBC)等胆汁淤积性疾病患者的皮肤瘙痒可能严重损害其生活质量。

背景和目标

患有原发性或继发性硬化性胆管炎(PSC,SSC)和原发性胆汁性胆管炎(PBC)等胆汁淤积性疾病患者的皮肤瘙痒可能严重损害其生活质量。苯扎贝特是一种广泛应用的过氧化物酶体增殖物受体(PPAR)激动剂,可通过减轻肝胆损伤减轻胆汁淤积相关的瘙痒。这项由研究人员发起的试验的目的是评估苯扎贝特对PSC,PBC和SSC患者瘙痒症状的治疗作用。

 

 

方法

研究人员将患者PSC,PBC或SSC且具有中度至重度瘙痒( >视觉模拟评分(VAS)5分)的患者纳入本项研究,随机给予患者接受安慰剂或苯扎贝特(400mg/d)治疗21天。主要观察终点是瘙痒评分减少> 50%。

 

 

结果

研究结果显示:74名随机患者中有70名完成了试验(44 PSC,24 PBC,2 SSC)。苯扎贝特可以使严重或中度瘙痒程度降低45%(41%PSC,55%PBC),安慰剂只能减少11%左右(p = 0.003)。对于次要终点,苯扎贝特主要降低了早晨(p = 0.01)和晚上(p = 0.007)的瘙痒强度,苯扎贝特还降低了血清碱性磷酸酶水平(-35%,p = 0.03),提示患者的胆道损害有所减少。血清胆汁酸和自分泌运动活性保持不变。

 

 

 

结论

在改善PSC和PBC患者的中度至重度瘙痒症方面,苯扎贝特是一种很好的药物。

 

 

原始出处:

Elsemieke de Vries. Et al. Fibrates for itch (FITCH) in fibrosing cholangiopathies: a double blind, randomized, placebo-controlled trial. Gastroenterology.2020.

 

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    2021-04-10 许安
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createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed May 19 08:11:40 CST 2021, time=2021-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073140, encodeId=b53c20e3140fe, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Apr 10 12:11:40 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1723562, encodeId=3d601e2356220, content=<a href='/topic/show?id=28f38e0672b' target=_blank style='color:#2F92EE;'>#苯扎贝特#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71220, encryptionId=6103e12204a, topicName=瘙痒症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6f82431450, createdName=lvygwyt2782, createdTime=Sun Oct 18 01:11:40 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505111, encodeId=77ca150511169, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sun Oct 18 01:11:40 CST 2020, time=2020-10-18, status=1, ipAttribution=), 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createdName=cmj15wellington, createdTime=Sun Oct 18 01:11:40 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892446, encodeId=98bb8924460b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q3auHgzwzM6tia9pyZiaPziaeLHadUZP17uiav8DTro6peFy5lvuO5EjYrG4ButKWVynGX1CUFFBbXhib9bjE77pkHw/132, createdBy=41785253089, createdName=医路前行4231, createdTime=Fri Oct 16 13:11:55 CST 2020, time=2020-10-16, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2065182, encodeId=f6812065182b4, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Jun 22 23:11:40 CST 2021, time=2021-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712581, encodeId=f8f01e1258180, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=87067, encryptionId=28f38e0672b, topicName=苯扎贝特)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d3633479896, createdName=flyingeagle88, createdTime=Mon Jan 04 10:11:40 CST 2021, time=2021-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302587, encodeId=8cfc130258e8f, content=<a href='/topic/show?id=b541e1219dc' target=_blank style='color:#2F92EE;'>#瘙痒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71219, encryptionId=b541e1219dc, topicName=瘙痒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d17305, createdName=listen318, createdTime=Sun Oct 18 01:11:40 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402913, encodeId=119014029139d, content=<a href='/topic/show?id=6103e12204a' target=_blank style='color:#2F92EE;'>#瘙痒症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71220, encryptionId=6103e12204a, topicName=瘙痒症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6f82431450, createdName=lvygwyt2782, createdTime=Sun Oct 18 01:11:40 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505111, encodeId=77ca150511169, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sun Oct 18 01:11:40 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619575, encodeId=501c16195e55f, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Oct 18 01:11:40 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628460, encodeId=ea6416284609d, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Sun Oct 18 01:11:40 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892446, encodeId=98bb8924460b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q3auHgzwzM6tia9pyZiaPziaeLHadUZP17uiav8DTro6peFy5lvuO5EjYrG4ButKWVynGX1CUFFBbXhib9bjE77pkHw/132, createdBy=41785253089, createdName=医路前行4231, createdTime=Fri Oct 16 13:11:55 CST 2020, time=2020-10-16, status=1, ipAttribution=)]
    2020-10-18 listen318
  6. [GetPortalCommentsPageByObjectIdResponse(id=2065182, encodeId=f6812065182b4, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Jun 22 23:11:40 CST 2021, time=2021-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712581, encodeId=f8f01e1258180, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  7. 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    2020-10-16 医路前行4231

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