AJG:慢性病毒性肝炎患者的酒精摄入量和死亡率之间的关系

2021-02-22 MedSci原创 MedSci原创

酒精摄入是造成全球医疗负担的主要因素,2016年,酒精导致的死亡占全球总死亡人数的8.8%,酒精是一种已知的明确的多种疾病(包括癌症,肝病)的危险因素。

      酒精摄入是造成全球医疗负担的主要因素,2016年,酒精导致的死亡占全球总死亡人数的8.8%,酒精是一种已知的明确的多种疾病(包括癌症,肝病)的危险因素。对于患有慢性乙型肝炎病毒(HBV)或丙型肝炎(HCV)的个人,大量饮酒与肝硬化和肝细胞癌的风险增加明显相关。本项研究通过美国国家的人群队列研究评估了慢性病毒性肝炎患者饮酒与全因和特定病因死亡率之间的关联。

 

 

      研究人员对2002年1月至2013年12月之间的364361名40-84岁的男性和女性进行了健康筛查,其中包括饮酒频率和饮酒量的评估,以评估所有原因和特定原因的死亡率。研究人员发现在没有慢性病毒性肝炎的参与者中,与轻,中度和重度饮酒者与非饮酒者相比,全因死亡率的完全调整的危险比(HRs)为0.92(95%[CI] 0.87–0.98),1.08(95%CI 1.01–1.16)和1.51(95%CI 1.33–1.72)。在慢性病毒性肝炎患者中,相应的HR分别为1.19(95%CI 1.05-1.36),1.23(95%CI 1.06-1.43),和1.69(95%CI 1.28-2.24),(P<0.001)。与没有慢性病毒性肝炎的参与者相比,患有慢性病毒性肝炎的参与者肝癌或肝病的发病率(HR 10.85,95%CI 9.74-12.09)和肝外癌症死亡率(HR 1.37,95%CI 1.26-1.49)显著上升。在慢性病毒性肝炎患者中,由于肝癌或肝病导致的高死亡率以及饮酒与肝癌或肝病死亡率呈相关关系。

 

      虽然道理显而易见但是仍要告诉大家:在慢性病毒性肝炎患者中,即使少量或中度饮酒也会增加全因死亡率。临床医生应建议慢性病毒性肝炎患者不要摄入任何酒精。

 

 

 

原始出处:

Sinn, Dong Hyun. Et al. Alcohol Intake and Mortality in Patients With Chronic Viral Hepatitis: A Nationwide Cohort Study.The American Journal of Gastroenterology.2021.

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    2021-12-07 lmm397
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    2021-10-09 howi
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    2021-06-11 minzju5052
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1860688, encodeId=dff2186068868, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Dec 07 21:33:39 CST 2021, time=2021-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807910, encodeId=45df180e910f1, content=<a href='/topic/show?id=dd7d8124144' target=_blank style='color:#2F92EE;'>#肝炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81241, encryptionId=dd7d8124144, topicName=肝炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Tue Sep 21 21:33:39 CST 2021, time=2021-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986404, encodeId=484819864042d, content=<a href='/topic/show?id=f3f1e0930ed' target=_blank style='color:#2F92EE;'>#病毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70930, encryptionId=f3f1e0930ed, topicName=病毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Oct 09 08:33:39 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057322, encodeId=3d7f205e32233, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Fri Jun 11 12:33:39 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2042908, encodeId=dce120429088a, content=<a href='/topic/show?id=981895492d6' target=_blank style='color:#2F92EE;'>#酒精摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95492, encryptionId=981895492d6, topicName=酒精摄入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=86b7385, createdName=lqrandywkz, createdTime=Fri Jan 21 19:33:39 CST 2022, time=2022-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264072, encodeId=7f0912640e21b, content=<a href='/topic/show?id=847353580bf' target=_blank style='color:#2F92EE;'>#慢性病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53580, encryptionId=847353580bf, topicName=慢性病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Wed Feb 24 11:33:39 CST 2021, time=2021-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=926743, encodeId=a7c4926e431c, content=⚫︎, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLp3B6jicwdibjbhKmwqvoc2hI2qCfp3iap4W1OFuuYxGV6NhzuBRTzZFqxhBs7I8vDlzzia4gLSWvkLw/132, createdBy=d27d2150652, createdName=指尖芭蕾, createdTime=Wed Feb 24 01:51:17 CST 2021, time=2021-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=926526, encodeId=92dd926526f1, content=😐😐😐, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210223/a921998836584427904cdd3ecad389e1/1f83c95c2dd3417cbf230c2bb3d35ca0.jpg, createdBy=f4254666114, createdName=174404746, createdTime=Tue Feb 23 08:14:28 CST 2021, time=2021-02-23, status=1, ipAttribution=)]
    2021-02-24 qjddjq
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    2021-02-24 指尖芭蕾

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    2021-02-23 174404746

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