Alzheimers Dementia:注意啦,人越胖,越容易变傻

2021-06-02 Freeman MedSci原创

在过去的几年里,研究表明,血管因素是导致晚年认知能力下降和痴呆的主要因素。尽管有这些丰富的数据,但包括体重指数(BMI)在内的关键心血管风险因素的时间和影响仍有争议。


在过去的几年里,研究表明,血管因素是导致晚年认知能力下降和痴呆的主要因素。尽管有这些丰富的数据,但包括体重指数(BMI)在内的关键心血管风险因素的时间和影响仍有争议。

例如,有研究表明,尽管中年的高BMI与痴呆症风险的增加有关,但晚年的高BMI可能与此无关,或似乎是保护性的。这些关联可能受到早期暴露的未测量的混杂影响,以及其他偏见。例如,痴呆症与晚年较高BMI的意外无效或反向关联可能是由于反向因果关系,反映了痴呆症的长期临床前阶段。这种不一致支持需要采用生命历程方法,在任何临床前神经退行性变化之前,如在成年早期测量BMI。

成年早期的BMI与痴呆症的关系还没有被彻底研究。有几种机制被假设为BMI与痴呆症的关系,包括血管、炎症,以及脂肪和脂肪相关激素(如瘦素)对大脑的直接影响。这些途径也被认为因性别而异,就像痴呆症的发病率一样。

鉴于美国成年人肥胖症持续增加,了解这种关系尤为重要。然而,这种研究大多由于缺乏可行性和难以跟踪参与者从成年早期到晚年的情况而受到阻碍,因为痴呆症几乎完全发生在这个时期。由于缺乏大型的、具有种族多样性的、完整覆盖成年人一生的单一美国队列,解决知识空白的唯一方法是利用生命历程的集合队列,来解决早期成年BMI是否是痴呆症的风险因素。

藉此,哥伦比亚大学的Adina Zeki Al Hazzouri等人,利用一个跨越生命历程的集合队列的BMI数据,探究了成年早期的BMI与晚年痴呆症发病率的关系。

他们利用心血管健康研究(CHS)和健康、老龄化和身体成分(Health ABC)队列,中的5104名老年人。我们使用一个具有完整成人寿命覆盖面的集合父母队列和以前建立的方法来估算成年早期和中年BMI。痴呆症是使用神经心理学测试量表、医疗记录和痴呆症相关药物使用等标准确定的。

他们发现,与成年早期BMI正常的女性相比,超重(OR=1.8)和肥胖(OR=2.45)的女性患痴呆症的几率更高,与中晚期BMI无关。在男性中也观察到类似的关系。

这个研究的重要意义在于,发现了随着美国成年人中肥胖症的日益流行,旨在减少痴呆症的努力可能需要在生命过程的早期开始预防和治疗肥胖症。

原文出处:

Zeki Al Hazzouri, A., Vittinghoff, E., Hoang, T., Golden, S. H., Fitzpatrick, A. L., Zhang, A., ... & Yaffe, K. (2021). Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort. _Alzheimer's & Dementia_.

 

 
 
 
 

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    2021-12-29 一己怀

    #学习#学到了很多

    0

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    2021-08-17 anminleiryan
  5. [GetPortalCommentsPageByObjectIdResponse(id=1718009, encodeId=77ba1e18009f2, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Feb 25 03:12:11 CST 2022, time=2022-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1085517, encodeId=1e06108551e10, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d25a5516768, createdName=一己怀, createdTime=Wed Dec 29 17:14:41 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779785, encodeId=1fce1e797854a, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Apr 07 18:12:11 CST 2022, time=2022-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878374, encodeId=a80118e83744c, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Tue Aug 17 03:12:11 CST 2021, time=2021-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338503, encodeId=22001338503e5, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Jun 03 19:12:11 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970559, encodeId=7eca9e05593c, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210603/0cb00ff0681a43df850f2c8f4f7814f0/d121f9de22ad4c53966f48be080e68ca.jpg, createdBy=7f085475251, createdName=CWRCWR, createdTime=Thu Jun 03 12:15:49 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970219, encodeId=625a9e02192d, content=减肥势在必行, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Wed Jun 02 06:38:05 CST 2021, time=2021-06-02, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1718009, encodeId=77ba1e18009f2, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Feb 25 03:12:11 CST 2022, time=2022-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1085517, encodeId=1e06108551e10, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d25a5516768, createdName=一己怀, createdTime=Wed Dec 29 17:14:41 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779785, encodeId=1fce1e797854a, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Apr 07 18:12:11 CST 2022, time=2022-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878374, encodeId=a80118e83744c, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Tue Aug 17 03:12:11 CST 2021, time=2021-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338503, encodeId=22001338503e5, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Jun 03 19:12:11 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970559, encodeId=7eca9e05593c, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210603/0cb00ff0681a43df850f2c8f4f7814f0/d121f9de22ad4c53966f48be080e68ca.jpg, createdBy=7f085475251, createdName=CWRCWR, createdTime=Thu Jun 03 12:15:49 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970219, encodeId=625a9e02192d, content=减肥势在必行, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Wed Jun 02 06:38:05 CST 2021, time=2021-06-02, status=1, ipAttribution=)]
    2021-06-03 CWRCWR

    涨知识了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1718009, encodeId=77ba1e18009f2, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Feb 25 03:12:11 CST 2022, time=2022-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1085517, encodeId=1e06108551e10, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d25a5516768, createdName=一己怀, createdTime=Wed Dec 29 17:14:41 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779785, encodeId=1fce1e797854a, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Apr 07 18:12:11 CST 2022, time=2022-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878374, encodeId=a80118e83744c, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Tue Aug 17 03:12:11 CST 2021, time=2021-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338503, encodeId=22001338503e5, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Jun 03 19:12:11 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970559, encodeId=7eca9e05593c, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210603/0cb00ff0681a43df850f2c8f4f7814f0/d121f9de22ad4c53966f48be080e68ca.jpg, createdBy=7f085475251, createdName=CWRCWR, createdTime=Thu Jun 03 12:15:49 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970219, encodeId=625a9e02192d, content=减肥势在必行, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Wed Jun 02 06:38:05 CST 2021, time=2021-06-02, status=1, ipAttribution=)]
    2021-06-02 学医无涯

    减肥势在必行

    0

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