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NEJM：LY-CoV555联合瑞德西韦不能缩短新冠肺炎住院患者恢复期

2020-12-26 MedSci原创 MedSci原创

新冠肺炎瑞德西韦LY-CoV555
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LY-CoV555与瑞德西韦联合治疗不能加快新冠肺炎住院患者恢复时间

抗病毒药物瑞德西韦可减少2019年冠状病毒病住院患者(Covid-19)的恢复时间，而地塞米松可降低患者死亡率，但临床上仍迫切需要更多有效的新冠肺炎药物治疗手段。Ly-COV555是一种单克隆中和抗体，在新冠肺炎门诊患者参与的研究中，Ly-COV555可降低病毒载量和患者住院或急诊风险。近日研究人员考察了其对Covid-19住院患者的效果。
 
无器官衰竭的新冠肺炎住院患者参与研究，在高质量的支持治疗基础上，随机接受LY-CoV555或安慰剂，支持治疗包括瑞德西韦、吸氧和糖皮质激素。LY-CoV555的剂量为7000mg，单次静脉注射给药，在1小时内完成。研究的主要终点为90天内持续恢复。
 
314名患者参与研究，其中LY-CoV555组163人，安慰剂组151人，平均的症状恢复期为7天。在第5天，LY-CoV555组81名患者（50%）以及安慰剂组81名患者（54%）其呼吸和肺部结果得到显著改善。在7项临床改善评估项中，与安慰剂相比，LY-CoV555占优的比值比为0.85。在包含死亡、严重不良事件以及5天内3-4级不良事件的安全性终点评估中，组间结果相似（19% vs 14%）。组间90天内持续恢复率差异不显著（rr=1.06）。
 
研究认为，LY-CoV555与瑞德西韦联合治疗不能加快新冠肺炎住院患者恢复时间。
 
原始出处：
 
ACTIV-3/TICO LY-CoV555 Study Group. A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19. N Engl J Med， December 22， 2020.

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  1. 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GetPortalCommentsPageByObjectIdResponse(id=1953046, encodeId=4371195304673, content=<a href='/topic/show?id=bafc5283ed3' target=_blank style='color:#2F92EE;'>#恢复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52837, encryptionId=bafc5283ed3, topicName=恢复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Mon Nov 29 09:22:47 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911360, encodeId=31e99113607c, content=不能缩短新冠肺炎住院患者恢复期, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:43:57 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911338, encodeId=be5f911338fd, content=LY-CoV555联合瑞德西韦不能缩短新冠肺炎住院患者恢复期！！！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:37:37 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911466, encodeId=60f991146645, content=很好的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sun Dec 27 22:44:04 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911175, encodeId=6a1f9111e5ae, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>学习了，了解最新动态, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sat Dec 26 23:46:34 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911146, encodeId=f14991114614, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a><a href='/topic/show?id=bfa968e24a1' target=_blank style='color:#2F92EE;'>#瑞德西韦#</a>那么单用瑞德西韦还有效，那不是矛盾么？看来瑞德西韦可能真没有用！, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=68724, encryptionId=bfa968e24a1, topicName=瑞德西韦)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Dec 26 21:38:30 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028919, encodeId=faca102891957, content=新冠肺炎，疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035538, encodeId=59f9103553865, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2022-06-04 屋顶瞄爱赏月

    签到学习

    0

  2. 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    2021-09-12 ms3000000161626604

    组间90天内持续恢复率差异不显著（rr=1.06）。

    0

  3. 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content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2021-11-29 by2009

    #恢复期#

    0

  4. 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GetPortalCommentsPageByObjectIdResponse(id=911338, encodeId=be5f911338fd, content=LY-CoV555联合瑞德西韦不能缩短新冠肺炎住院患者恢复期！！！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:37:37 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911466, encodeId=60f991146645, content=很好的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sun Dec 27 22:44:04 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911175, encodeId=6a1f9111e5ae, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>学习了，了解最新动态, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sat Dec 26 23:46:34 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911146, encodeId=f14991114614, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a><a href='/topic/show?id=bfa968e24a1' target=_blank style='color:#2F92EE;'>#瑞德西韦#</a>那么单用瑞德西韦还有效，那不是矛盾么？看来瑞德西韦可能真没有用！, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=68724, encryptionId=bfa968e24a1, topicName=瑞德西韦)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Dec 26 21:38:30 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028919, encodeId=faca102891957, content=新冠肺炎，疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035538, encodeId=59f9103553865, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2020-12-27 oo902

    不能缩短新冠肺炎住院患者恢复期

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=911338, encodeId=be5f911338fd, content=LY-CoV555联合瑞德西韦不能缩短新冠肺炎住院患者恢复期！！！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:37:37 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911466, encodeId=60f991146645, content=很好的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sun Dec 27 22:44:04 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911175, encodeId=6a1f9111e5ae, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>学习了，了解最新动态, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sat Dec 26 23:46:34 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911146, encodeId=f14991114614, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a><a href='/topic/show?id=bfa968e24a1' target=_blank style='color:#2F92EE;'>#瑞德西韦#</a>那么单用瑞德西韦还有效，那不是矛盾么？看来瑞德西韦可能真没有用！, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=68724, encryptionId=bfa968e24a1, topicName=瑞德西韦)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Dec 26 21:38:30 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028919, encodeId=faca102891957, content=新冠肺炎，疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035538, encodeId=59f9103553865, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2020-12-27 oo902

    LY-CoV555联合瑞德西韦不能缩短新冠肺炎住院患者恢复期！！！！！

    0

  6. 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level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=68724, encryptionId=bfa968e24a1, topicName=瑞德西韦)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Dec 26 21:38:30 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028919, encodeId=faca102891957, content=新冠肺炎，疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035538, encodeId=59f9103553865, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2020-12-27 医路顺丰

    很好的文章，学习了

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=1953046, encodeId=4371195304673, content=<a href='/topic/show?id=bafc5283ed3' target=_blank style='color:#2F92EE;'>#恢复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52837, encryptionId=bafc5283ed3, topicName=恢复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Mon Nov 29 09:22:47 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911360, encodeId=31e99113607c, content=不能缩短新冠肺炎住院患者恢复期, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:43:57 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911338, encodeId=be5f911338fd, content=LY-CoV555联合瑞德西韦不能缩短新冠肺炎住院患者恢复期！！！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:37:37 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911466, encodeId=60f991146645, content=很好的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sun Dec 27 22:44:04 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911175, encodeId=6a1f9111e5ae, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>学习了，了解最新动态, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sat Dec 26 23:46:34 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911146, encodeId=f14991114614, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a><a href='/topic/show?id=bfa968e24a1' target=_blank style='color:#2F92EE;'>#瑞德西韦#</a>那么单用瑞德西韦还有效，那不是矛盾么？看来瑞德西韦可能真没有用！, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=68724, encryptionId=bfa968e24a1, topicName=瑞德西韦)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Dec 26 21:38:30 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028919, encodeId=faca102891957, content=新冠肺炎，疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035538, encodeId=59f9103553865, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2020-12-26 医路顺丰

    #新冠肺炎#学习了，了解最新动态

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1224450, encodeId=9a9f1224450c3, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sat Jun 04 19:47:59 CST 2022, time=2022-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016762, encodeId=5a2a1016e620f, content=组间90天内持续恢复率差异不显著（rr=1.06）。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=ms3000000161626604, createdTime=Sun Sep 12 14:37:10 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953046, encodeId=4371195304673, content=<a href='/topic/show?id=bafc5283ed3' target=_blank style='color:#2F92EE;'>#恢复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52837, encryptionId=bafc5283ed3, topicName=恢复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Mon Nov 29 09:22:47 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911360, encodeId=31e99113607c, content=不能缩短新冠肺炎住院患者恢复期, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:43:57 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911338, encodeId=be5f911338fd, content=LY-CoV555联合瑞德西韦不能缩短新冠肺炎住院患者恢复期！！！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:37:37 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911466, encodeId=60f991146645, content=很好的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sun Dec 27 22:44:04 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911175, encodeId=6a1f9111e5ae, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>学习了，了解最新动态, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sat Dec 26 23:46:34 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911146, encodeId=f14991114614, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a><a href='/topic/show?id=bfa968e24a1' target=_blank style='color:#2F92EE;'>#瑞德西韦#</a>那么单用瑞德西韦还有效，那不是矛盾么？看来瑞德西韦可能真没有用！, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=68724, encryptionId=bfa968e24a1, topicName=瑞德西韦)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Dec 26 21:38:30 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028919, encodeId=faca102891957, content=新冠肺炎，疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035538, encodeId=59f9103553865, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2020-12-26 lovetcm

    #新冠肺炎##瑞德西韦#那么单用瑞德西韦还有效，那不是矛盾么？看来瑞德西韦可能真没有用！

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1224450, encodeId=9a9f1224450c3, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sat Jun 04 19:47:59 CST 2022, time=2022-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016762, encodeId=5a2a1016e620f, content=组间90天内持续恢复率差异不显著（rr=1.06）。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=afe65591083, createdName=ms3000000161626604, createdTime=Sun Sep 12 14:37:10 CST 2021, time=2021-09-12, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=911338, encodeId=be5f911338fd, content=LY-CoV555联合瑞德西韦不能缩短新冠肺炎住院患者恢复期！！！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:37:37 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911466, encodeId=60f991146645, content=很好的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sun Dec 27 22:44:04 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911175, encodeId=6a1f9111e5ae, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>学习了，了解最新动态, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sat Dec 26 23:46:34 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911146, encodeId=f14991114614, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a><a href='/topic/show?id=bfa968e24a1' target=_blank style='color:#2F92EE;'>#瑞德西韦#</a>那么单用瑞德西韦还有效，那不是矛盾么？看来瑞德西韦可能真没有用！, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=68724, encryptionId=bfa968e24a1, topicName=瑞德西韦)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Dec 26 21:38:30 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028919, encodeId=faca102891957, content=新冠肺炎，疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035538, encodeId=59f9103553865, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2020-12-26 公卫新人

    新冠肺炎，疫情何时才能消失

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=1953046, encodeId=4371195304673, content=<a href='/topic/show?id=bafc5283ed3' target=_blank style='color:#2F92EE;'>#恢复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52837, encryptionId=bafc5283ed3, topicName=恢复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e2c339, createdName=by2009, createdTime=Mon Nov 29 09:22:47 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911360, encodeId=31e99113607c, content=不能缩短新冠肺炎住院患者恢复期, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:43:57 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911338, encodeId=be5f911338fd, content=LY-CoV555联合瑞德西韦不能缩短新冠肺炎住院患者恢复期！！！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:37:37 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911466, encodeId=60f991146645, content=很好的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sun Dec 27 22:44:04 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911175, encodeId=6a1f9111e5ae, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>学习了，了解最新动态, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sat Dec 26 23:46:34 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911146, encodeId=f14991114614, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a><a href='/topic/show?id=bfa968e24a1' target=_blank style='color:#2F92EE;'>#瑞德西韦#</a>那么单用瑞德西韦还有效，那不是矛盾么？看来瑞德西韦可能真没有用！, beContent=null, objectType=article, channel=null, level=null, likeNumber=182, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=68724, encryptionId=bfa968e24a1, topicName=瑞德西韦)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Dec 26 21:38:30 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028919, encodeId=faca102891957, content=新冠肺炎，疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035538, encodeId=59f9103553865, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Dec 26 16:22:47 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2020-12-26 旺医

    顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息

    0

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