Paediatr Anaesth:不同浓度氧吸入对机械通气患儿肺不张的影响:随机对照研究

2019-12-06 anesthGH “罂粟花”微信号

高浓度的吸入氧浓度(FiO2)会导致直接的肺毒性以及肺部并发症,本研究的目的是通过肺部超声来评估术中不同FiO2对机械通气患儿发生肺不张的影响。

背景与目的

高浓度的吸入氧浓度(FiO2)会导致直接的肺毒性以及肺部并发症,本研究的目的是通过肺部超声来评估术中不同FiO2对机械通气患儿发生肺不张的影响。

方  法

86名小于6周岁择期在全麻下行非心脏手术的患儿被随机分为两组:高FiO2组和低FiO2组。低FiO2组吸入30%的空氧混合气体,高FiO2组吸入100%纯氧。设定潮气量为8 mL/kg,PEEP 5cm H2O,呼吸次数15-40次/分,使EtCO2 维持在35‐45 mmHg。主要指标:术后肺超声检查中严重肺不张的发生率。次要指标:术前严重肺不张、术中及术后(24小时内)低氧(SpO2<95%)、术后发热(24小时内体温≧37.5°C),以及术后24小时内的肺部并发症的发生情况。

结 果

低FiO2组术后严重肺不张的发生率为28%,而高FiO2组的发生率为37%,两者之间没有统计学差异 (28% vs 37%;P =0.357; OR= 1.531; 95% CI: 0.617‐3.800) 。两组间术前肺超声的显着肺不张发生率也相似(12%vs9%;;P=0.725;OR= 0.779;95%CI:0.194–3.125)。其余指标无统计学差异。

结 论

吸入不同浓度的氧并不会对机械通气的患儿严重肺不张的发生产生影响。

原始出处:

Song IK, Jang YE, Lee JH, et al. Effect of different fraction of inspired oxygen on development of atelectasis in mechanically ventilated children A randomized controlled trial. Paediatr Anaesth. 2019 Oct;29(10): 1033-1039. doi: 10.1111/pan.13718.

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    2020-06-06 mnda
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10:16:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544618, encodeId=a7ba154461874, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Sun Dec 08 10:16:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038900, encodeId=4474103890089, content=高质量研究,读起来真爽,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Fri Dec 06 22:16:00 CST 2019, time=2019-12-06, status=1, ipAttribution=)]
    2020-03-26 amyloid
  5. 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10:16:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544618, encodeId=a7ba154461874, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Sun Dec 08 10:16:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038900, encodeId=4474103890089, content=高质量研究,读起来真爽,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Fri Dec 06 22:16:00 CST 2019, time=2019-12-06, status=1, ipAttribution=)]
  6. 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10:16:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544618, encodeId=a7ba154461874, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Sun Dec 08 10:16:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038900, encodeId=4474103890089, content=高质量研究,读起来真爽,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Fri Dec 06 22:16:00 CST 2019, time=2019-12-06, status=1, ipAttribution=)]
    2020-06-29 AspirantSuo
  7. 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10:16:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544618, encodeId=a7ba154461874, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Sun Dec 08 10:16:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038900, encodeId=4474103890089, content=高质量研究,读起来真爽,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Fri Dec 06 22:16:00 CST 2019, time=2019-12-06, status=1, ipAttribution=)]
    2019-12-08 makuansheng
  8. 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10:16:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544618, encodeId=a7ba154461874, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Sun Dec 08 10:16:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038900, encodeId=4474103890089, content=高质量研究,读起来真爽,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Fri Dec 06 22:16:00 CST 2019, time=2019-12-06, status=1, ipAttribution=)]
    2019-12-06 肿瘤克星

    高质量研究,读起来真爽,谢谢梅斯

    0

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