Sci Immunol：CD8+ T细胞对新冠病毒感染反应的多重分子特性

2021-01-25 MedSci原创 MedSci原创

重症COVID-19患者的SARS-CoV-2反应CD8+ T细胞的耗竭特征受损？

新冠病毒（SARS-CoV-2）已经肆虐全球一年了，然而，CD8⁺ T细胞对新冠病毒感染反应的分子特性仍尚未完全明确。近日，《Science Immunology》杂志上发表了一篇文章，研究人员发现重症COVID-19患者的SARS-CoV-2反应CD8⁺ T细胞的耗竭特征受损。

研究人员采用校正的抗体-反应T细胞富集（ARTE）试验分析了来自39位COVID-19患者和10位健康个体的8万多个病毒反应性CD8⁺ T细胞的单细胞转录组，发现基于对SRS-CoV-2反应的主要的CD8⁺ T细胞是否耗竭可将COVID-19患者分成两组。

CD8⁺T细胞对COVID-19疾病的反应

在“耗竭”亚组中，与重症患者相比，病情较轻的患者的SRS-CoV-2反应细胞常增多，表现出较弱的细胞毒性和炎性特征。相反，在“无耗竭”亚组中，重症患者的SRS-CoV-2反应细胞中与共刺激、促存活NF-κB信号和抗凋亡通路相关的转录本富集，提示重症COVID-19患者产生了大量的CD8+ T细胞记忆反应。

病毒反应性CD8⁺T细胞的转录异质性

来源于健康个体对流感病毒和呼吸道合胞病毒反应的CD8⁺ T细胞则表现出多重功能特征，以及糖酵解增强。在COVID-19患者和未暴露于SARS-CoV-2的健康对照个体基本没有具有此特征的SARS-CoV-2反应细胞。

总之，该单细胞分析研究揭示了CD8⁺ T细胞对SARS-CoV-2应答的特性的多样性。

原始出处：

Anthony Kusnadi, et al. Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells. Science Immunology 21 Jan 2021:Vol. 6, Issue 55, eabe4782. DOI: 10.1126/sciimmunol.abe4782

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2021-01-27 ms691033630344116

#CD8#

46 0
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2021-01-26 ms5000000477494371

学习了

85 0
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2021-01-26 1354281cf1m

机制的研究更为重要

74 0
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2021-01-25 公卫新人

新冠肺炎，疫情何时才能消失

55 0
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2021-01-25 123465c7m53暂无昵称

学习了

83 0
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2021-01-25 yangchou

CD8+T细胞反应多样性也显示新冠肺炎感染患者不同结局。

87 0

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