JASN:肾移植术后甲状旁腺功能亢进:手术比药物更有效

2015-12-17 cuiqian译 MedSci原创

一项由Bellvitge生物医学研究所肾脏病学组(IDIBELL)和Bellvitge大学附属医院(HUB)的研究人员领导的一项研究,比较了三发性甲状旁腺功能亢进即肾脏移植后手术 vs 药物治疗的结果。该研究结果已发表在影响最大的Journal of the American Society of Nephrology杂志上。这是第一个比较该疾病这两种治疗方法的临床试验,并由卡洛斯三世卫生研究所自

一项由Bellvitge生物医学研究所肾脏病学组(IDIBELL)和Bellvitge大学附属医院(HUB)的研究人员领导的一项研究,比较了肾脏移植后三级甲状旁腺功能亢进患者手术 vs 药物治疗的结果。该研究结果已发表在影响最大的Journal of the American Society of Nephrology杂志上。

这是第一个比较该疾病这两种治疗方法的临床试验,并由卡洛斯三世卫生研究所自主开展,并呼吁的独立的临床研究项目。

约50%的肾移植患者,发生三级甲状旁腺功能亢进。这种并发症造成过多的钙蓄积,高血钙导致心血管疾病恶化、骨损失及移植器官的损害等。

该研究共包括30例患者。其中一半进行手术,而另一半则用常规的药物。研究人员已经发现,手术可完全控制高钙血症,使甲状旁腺激素(PTH)的分泌正常化,并提高骨密度。然而药物治疗只能控制67%病例的过量的钙,对PTH没有影响,甚至会降低骨密度的下降速度,但并不会停止该过程。

这项研究的首席研究员,Josep Maria Cruzado,解释说,“如果我们有一个外科团队,有这种类型的操作经验,在这样情况下我们就会建议手术,因为从效率的角度考虑,第一手术是治愈性的治疗;从经济角度来看:手术的费用相当于7-14个月的治疗,而药物必须长期服用,不能停止。”

这项研究的结果可能改变三级甲状旁腺功能亢进的临床实践。

Cruzado还解释说,这是一种微创手术,包括住院只需要一天的时间。

原始出处:

J. M. Cruzado, P. Moreno, J. V. Torregrosa,A Randomized Study Comparing Parathyroidectomy with Cinacalcet for Treating Hypercalcemia in Kidney Allograft Recipients with Hyperparathyroidism,Journal of the American Society of Nephrology, ,2015.12.16

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    2016-07-15 chenhongpeng
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1808978, encodeId=90d618089e87d, content=<a href='/topic/show?id=00b68262e91' target=_blank style='color:#2F92EE;'>#肾移植术后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82627, encryptionId=00b68262e91, topicName=肾移植术后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Sat Nov 19 23:25:00 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941272, encodeId=2cf819412e2d2, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Fri Jul 15 07:25:00 CST 2016, time=2016-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776553, encodeId=27001e7655315, content=<a href='/topic/show?id=673582626c7' target=_blank style='color:#2F92EE;'>#肾移植术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82626, encryptionId=673582626c7, topicName=肾移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Nov 07 05:25:00 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998890, encodeId=5f91199889084, content=<a href='/topic/show?id=8e2ee5200ee' target=_blank style='color:#2F92EE;'>#移植术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75200, encryptionId=8e2ee5200ee, topicName=移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Feb 01 15:25:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49490, encodeId=60d049490e0, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Sun Dec 27 18:54:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49491, encodeId=69e949491a9, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Sun Dec 27 18:54:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48282, encodeId=c8c54828260, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 16:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379536, encodeId=3fca13e953667, content=<a href='/topic/show?id=82e369829c0' target=_blank style='color:#2F92EE;'>#甲状旁腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69829, encryptionId=82e369829c0, topicName=甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b796455, createdName=jmtang, createdTime=Sat Dec 19 09:25:00 CST 2015, time=2015-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452438, encodeId=bb111452438ed, content=<a href='/topic/show?id=d90469826e2' target=_blank style='color:#2F92EE;'>#甲状旁腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69826, encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Sat Dec 19 09:25:00 CST 2015, time=2015-12-19, status=1, ipAttribution=)]
    2016-02-01 cy0324
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    2015-12-27 wzf990214

    有意思

    0

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    2015-12-27 wzf990214

    赞一个

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1808978, encodeId=90d618089e87d, content=<a href='/topic/show?id=00b68262e91' target=_blank style='color:#2F92EE;'>#肾移植术后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82627, encryptionId=00b68262e91, topicName=肾移植术后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Sat Nov 19 23:25:00 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941272, encodeId=2cf819412e2d2, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Fri Jul 15 07:25:00 CST 2016, time=2016-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776553, encodeId=27001e7655315, content=<a href='/topic/show?id=673582626c7' target=_blank style='color:#2F92EE;'>#肾移植术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82626, encryptionId=673582626c7, topicName=肾移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Nov 07 05:25:00 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998890, encodeId=5f91199889084, content=<a href='/topic/show?id=8e2ee5200ee' target=_blank style='color:#2F92EE;'>#移植术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75200, encryptionId=8e2ee5200ee, topicName=移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Feb 01 15:25:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49490, encodeId=60d049490e0, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Sun Dec 27 18:54:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49491, encodeId=69e949491a9, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Sun Dec 27 18:54:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48282, encodeId=c8c54828260, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 16:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379536, encodeId=3fca13e953667, content=<a href='/topic/show?id=82e369829c0' target=_blank style='color:#2F92EE;'>#甲状旁腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69829, encryptionId=82e369829c0, topicName=甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b796455, createdName=jmtang, createdTime=Sat Dec 19 09:25:00 CST 2015, time=2015-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452438, encodeId=bb111452438ed, content=<a href='/topic/show?id=d90469826e2' target=_blank style='color:#2F92EE;'>#甲状旁腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69826, encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Sat Dec 19 09:25:00 CST 2015, time=2015-12-19, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    好文章,值得看。

    0

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