Hypertension:根据年龄的血压对糖尿病患者终末期肾脏病的影响

2022-05-31 MedSci原创 MedSci原创

较高的收缩压和舒张压会增加糖尿病患者发生终末期肾病的风险,特别是年轻患者将面临更大的风险。

糖尿病是终末期肾脏疾病(ESRD)的一个重要危险因素。高血压在肾衰竭的发生发展中也起着至关重要的作用。随着肾功能下降,血压升高,进而加重高血压。此外,随着慢性肾脏疾病(CKD)的恶化,血压变得更难控制,血压升高和肾功能恶化之间形成恶性循环。因此,对高危高血压患者进行早期诊断和及时治疗至关重要。然而,并没有针对年龄或收缩压和舒张压的具体高血压治疗指南

近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在评估年龄相关性血压对糖尿病患者终末期肾脏疾病(ESRD)发生发展的影响。

从2009年到2012年期间,研究人员从韩国国家健康筛查项目中选择了2563870名年龄20岁以上的糖尿病患者,并随访到2019年底。研究人员将参与者按年龄和血压进行分组,并计算了ESRD的风险比。

在7.15年的中位随访期间,ESRD的发生率随着收缩压和舒张压的增加而增加。年龄小于40岁且舒张压≥100mmHg的患者ESRD的风险比最高。收缩压和舒张压对ESRD发展的影响随年龄的增长而有所减弱(年龄和收缩压的交互作用P<0.0001,年龄和舒张压的交互作用P<0.0022)。性别、降压药物、慢性肾脏病史亚组分析显示,年龄小于40岁、未服用降压药物、有慢性肾脏病的男性发生ESRD的风险比高于女性、年龄大于40岁、服用降压药物和非慢性肾病组。

由此可见,较高的收缩压和舒张压会增加糖尿病患者发生终末期肾病的风险,特别是年轻患者将面临更大的风险。因此,在年轻患者中加强血压管理是必要的,以预防ESRD。

原始出处:

Eun Hui Bae.et al.Effects of Blood Pressure According to Age on End-Stage Renal Disease Development in Patients With Patients With Diabetes: A Nationwide Population-Based Cohort Study.Hypertension.2022.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.18881

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    2022-11-14 feather89
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    2022-06-14 ms8000002131411968

    看来血压一定要控制好

    0

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    2022-05-31 1649020726

    学习

    0

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    2022-05-31 ms8000001296067513

    学习

    0

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