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CLIN CANCER RES：GRP78抗体增强胶质母细胞瘤及非小细胞肺癌放疗疗效

2017-05-26 MedSci MedSci原创

胶质母细胞瘤非小细胞肺癌放疗
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非小细胞肺癌及胶质母细胞瘤预后差。两种肿瘤高表达GRP78，GRP78在放疗抵抗及肿瘤复发方面起到一定作用。CLIN CANCER RES近期发表了一篇文章，研究抗GRP78抗体以及抗GRP78抗体联合放疗对非小细胞肺癌及胶质母细胞瘤的影响。

非小细胞肺癌及胶质母细胞瘤预后差。两种肿瘤高表达GRP78，GRP78在放疗抵抗及肿瘤复发方面起到一定作用。CLIN CANCER RES近期发表了一篇文章，研究抗GRP78抗体以及抗GRP78抗体联合放疗对非小细胞肺癌及胶质母细胞瘤的影响。

作者使用抗GRP78抗体处理非小细胞肺癌及胶质母细胞瘤细胞系，观察肿瘤增殖、细胞死亡以及PI3K/Akt/mTOR信号通路情况。在肿瘤鼠模型中评估抗GRP78抗体联合化疗对肿瘤生长的影响。研究结果表明，在非小细胞肺癌及胶质母细胞瘤细胞系中抗GRP78抗体可以抑制细胞增殖，增强细胞凋亡。抗GRP78抗体还可以全面抑制PI3K/Akt/mTOR信号通路。在两种肿瘤鼠模型体内实验中，抗GRP78抗体联合放疗可以显着降低肿瘤生长速度。

文章最后认为，在体内及体外实验中抗GRP78抗体具有抗肿瘤活性并可以增强放疗对非小细胞肺癌及胶质母细胞瘤的疗效。GRP78是一种潜在的治疗靶点，抗GRP78抗体可以单独使用或与放疗联合治疗肿瘤。

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    2018-01-02 lingaifan

    #非小细胞#

    0

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    2017-09-10 30397604

    #胶质母细胞#

    0

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    2017-07-04 huperzia

    #母细胞瘤#

    0

  4. 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encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Sun May 28 12:27:00 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203075, encodeId=8c062030e5cf, content=阅读了，谢谢分享，学习了很多有用的知识！, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/08/24/26b17bef207f5a16bb76644d2b22859e.jpg, createdBy=799d1992408, createdName=流逝的青春, createdTime=Sat May 27 06:46:29 CST 2017, time=2017-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203071, encodeId=59472030e150, content=阅读了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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createdName=laymankey, createdTime=Fri May 26 22:48:01 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202911, encodeId=328f20291196, content=CLINCANCERRES近期发表了一篇文章，研究抗GRP78抗体以及抗GRP78抗体联合放疗对非小细胞肺癌及胶质母细胞瘤的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri May 26 22:42:17 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202904, encodeId=c62e20290406, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri May 26 22:20:10 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-28 spoonycyy

    #细胞瘤#

    0

  5. 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createdName=laymankey, createdTime=Fri May 26 22:48:01 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202911, encodeId=328f20291196, content=CLINCANCERRES近期发表了一篇文章，研究抗GRP78抗体以及抗GRP78抗体联合放疗对非小细胞肺癌及胶质母细胞瘤的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri May 26 22:42:17 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202904, encodeId=c62e20290406, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri May 26 22:20:10 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-27 流逝的青春

    阅读了，谢谢分享，学习了很多有用的知识！

    0

  6. 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createdName=laymankey, createdTime=Fri May 26 22:48:01 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202911, encodeId=328f20291196, content=CLINCANCERRES近期发表了一篇文章，研究抗GRP78抗体以及抗GRP78抗体联合放疗对非小细胞肺癌及胶质母细胞瘤的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri May 26 22:42:17 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202904, encodeId=c62e20290406, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri May 26 22:20:10 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-27 刘煜

    阅读了谢谢分享。

    0

  7. 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authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat May 27 06:44:10 CST 2017, time=2017-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203026, encodeId=341820302678, content=学习了，谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat May 27 05:32:47 CST 2017, time=2017-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202922, encodeId=f2172029225c, content=感谢分享一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Fri May 26 22:48:01 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202911, encodeId=328f20291196, content=CLINCANCERRES近期发表了一篇文章，研究抗GRP78抗体以及抗GRP78抗体联合放疗对非小细胞肺癌及胶质母细胞瘤的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri May 26 22:42:17 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202904, encodeId=c62e20290406, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri May 26 22:20:10 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-27 1e0f8808m18(暂无匿称)

    学习了，谢谢分享。

    0

  8. 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createdName=laymankey, createdTime=Fri May 26 22:48:01 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202911, encodeId=328f20291196, content=CLINCANCERRES近期发表了一篇文章，研究抗GRP78抗体以及抗GRP78抗体联合放疗对非小细胞肺癌及胶质母细胞瘤的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri May 26 22:42:17 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202904, encodeId=c62e20290406, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri May 26 22:20:10 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-26 laymankey

    感谢分享一下！

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri May 26 22:20:10 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-26 有备才能无患

    CLINCANCERRES近期发表了一篇文章，研究抗GRP78抗体以及抗GRP78抗体联合放疗对非小细胞肺癌及胶质母细胞瘤的影响。

    0

  10. 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createdName=laymankey, createdTime=Fri May 26 22:48:01 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202911, encodeId=328f20291196, content=CLINCANCERRES近期发表了一篇文章，研究抗GRP78抗体以及抗GRP78抗体联合放疗对非小细胞肺癌及胶质母细胞瘤的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri May 26 22:42:17 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202904, encodeId=c62e20290406, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri May 26 22:20:10 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-26 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

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该患者术后四周，开始接受放疗和替莫唑胺治疗。术后2个月随访，该患者无头痛症状，以及无神经功能缺损。